A5054691132- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Plant Pathogens and Fungal Diseases
- Mycotoxins in Agriculture and Food
- Plant Molecular Biology Research
- Genetic Mapping and Diversity in Plants and Animals
- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- Plant nutrient uptake and metabolism
- Plant Disease Resistance and Genetics
- Circular RNAs in diseases
- Pancreatitis Pathology and Treatment
- RNA Research and Splicing
- Plant-Microbe Interactions and Immunity
- Protein Tyrosine Phosphatases
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- COVID-19 diagnosis using AI
- COVID-19 and healthcare impacts
- Cancer, Hypoxia, and Metabolism
- Congenital gastrointestinal and neural anomalies
- Long-Term Effects of COVID-19
- Extracellular vesicles in disease
- Immune cells in cancer
Jining Medical University
2024
Union Hospital
2019-2024
Huazhong University of Science and Technology
2019-2024
Henan Agricultural University
2019-2023
Union Hospital
2020-2023
Henan Academy of Agricultural Sciences
2021-2023
Wuhan Union Hospital
2020-2021
Zhengzhou City Hospital
2013-2020
Tianjin Medical University General Hospital
2020
Taihe Hospital
2020
See Covering the Cover synopsis on page 2019. Because of accumulating evidence pointing to continuous person-to-person transmission coronavirus disease 2019 (COVID-19) in hospital and family settings,1Chan J.F. et al.Lancet. 2020; 395: 514-523Abstract Full Text PDF PubMed Scopus (6268) Google Scholar,2Phan L.T. al.N Engl J Med. 382: 872-874Crossref (825) Scholar World Health Organization has recently declared COVID-19 a public health emergency international concern. Fever respiratory...
Abstract Background Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several epithelial cancers and closely associated with poor prognosis. However, the role of TM4SF1 its potential mechanism colorectal cancer (CRC) remain elusive. Methods We investigated expression Oncomine, Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases confirmed results by immunohistochemistry (IHC), qPCR Western blotting (WB) CRC tissues. The effect on epithelial-to-mesenchymal...
Glycolysis is a pivotal process in metabolic reprogramming of tumorigenesis. Previous research has indicated that lncRNAs might play crucial roles glycolysis various tumors. However, the function pancreatic cancer not been fully elucidated.Bio-information analyses were applied to reveal potential glycolysis-associated lncRNA. RT-PCR and fluorescence situ hybridization (FISH) assays detect expression antisense RNA1 DICER1 (DICER1-AS1) tissues cell lines. Gain- loss-of-function experiments...
Stalk rot caused by Fusarium verticillioides (Fv) is one of the most destructive diseases in maize production. The defence response root system to Fv invasion important for plant growth and development. Dissection cell type-specific infection its underlying transcription regulatory networks will aid understanding mechanism roots invasion. Here, we reported transcriptomes 29 217 single cells derived from tips two inbred lines inoculated with mock condition, identified seven major types 21...
Long non-coding RNAs (LncRNAs) have been extensively studied to play essential roles in tumor progression. However, more in-depth studies are waiting be solved on how lncRNAs regulate the progression of hepatocellular carcinoma (HCC).Different expression levels HCC cells were compared by analysis Gene Expression Omnibus and The Cancer Genome Atlas databases. effects lncRNA FTO Intronic Transcript 1 (FTO-IT1) assessed gain- loss-of-function experiments. Colony formation assay, Edu glucose...
Glycolysis exerts a key role in the metabolic reprogramming of cancer.Specific long non-coding RNAs (lncRNAs) have been identified to exhibit oncogenic glycolysis regulation.Nevertheless, precise mechanisms by which glycolysis-related lncRNAs control hepatocellular carcinoma (HCC) are still unknown.We profiled and analyzed glycolysis-associated lncRNA signatures using HCC specimens from The Cancer Genome Atlas (TCGA) dataset.Considerable upregulation SLC2A1-DT was noted tissues; this...
Rationale: PLAGL2 (pleomorphic adenoma gene like-2), a zinc finger PLAG transcription factor, is aberrantly expressed in several malignant tumors. However, the biological roles of and its underlying mechanism gastric cancer (GC) remain unclear. Methods: A series experiments vitro vivo were conducted to reveal role GC progression. Results: The data revealed that promotes cell proliferation, migration, invasion, EMT vivo. Mechanistically, we demonstrated critical stabilization snail family...
Abstract Background Previous studies have indicated that chronic emotional stressors likely participate in the occurrence of cancers. However, direct evidence connecting stress and colorectal cancer development remains almost completely unexplored. Methods Chronic mouse model was used to investigate influence on tumorigenesis. Several major agonists antagonists adrenergic receptors were applied effects β-adrenergic signaling CRC. Chromatin immunoprecipitation assays (CHIP) binding p53 CEBPB...
Abstract Background Research has indicated that the emergence of Schwann cells around premalignant lesions colon cancer might be an early indicator promoting onset tumorigenesis. The present study explored communication between and cells. Methods Immunofluorescence analyses were conducted to examine differential distribution within tissues normal tissues. CCK8 assay, colony formation wound healing transwell assay performed investigate interaction Exosomes derived from isolated further...
Background & AimsStudies have demonstrated that activated pancreatic stellate cells (PSCs) play a crucial role in fibrogenesis chronic pancreatitis (CP); however, the precise mechanism for PSCs activation has not been fully elucidated. We analyzed of injured acinar (iPACs) CP.MethodsSphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) signaling was evaluated experimental CP induced by cerulein injection or duct ligation, as well PACs cholecystokinin. The and fibrosis samples...
Fusarium stalk rot caused by verticillioides is one of the most devastating diseases maize that causes significant yield losses and poses potential security concerns for foods worldwide. The underlying mechanisms plants regulating defence against disease remain poorly understood. Here, integrative proteomic transcriptomic analyses were employed to identify pathogenesis-related protein genes comparing differentially expressed proteins (DEPs) (DEGs) in stalks after inoculation with F....
Crop yield is determined by the capacity of plant canopy to capture light energy and store nitrogen (Sinclair Sheehy, 1999), which in turn depends mostly on photosynthetic rate per se architecture plant. Leaf angle (LA), defined as inclination between leaf blade midrib vertical culm, one most important parameters describing (Anderson Denmead, 1969). It a complex trait, several related quantitative trait loci (QTLs) have been identified; however, only two these functionally characterized...
Abstract Background We previously demonstrated that the pleomorphic adenoma gene like-2 (PLAGL2) is involved in pathogenesis of Hirschsprung disease. Enhanced PLAGL2 expression was observed several malignant tumours. However, exact function and its underlying mechanism colorectal cancer (CRC) remain largely unknown. Methods Immunohistochemical analysis performed. A series vitro vivo experiments were conducted to reveal role progression CRC. Results significantly associated with EMT-related...
Evidence has shown that microRNAs (miRNAs) participate in the progression of CRC. Previous studies have indicated miR-214-3p is abnormally expressed various malignant tumors. However, biological function it plays CRC and potential mechanism are unclear. Here, we demonstrated was obviously downregulated Moreover, found a strong correlation between level tumor size lymphatic metastasis. Furthermore, when decreased by an Lv-miR-214-3p inhibitor, proliferation migration SW480 HCT116 cells were...
Abstract The growth and development of maize are negatively affected by various abiotic stresses including drought, high salinity, extreme temperature, strong wind. Therefore, it is important to understand the molecular mechanisms underlying stress resistance in maize. In present work, we identified that a novel NAC transcriptional factor, ZmNST3 , enhances lodging drought tolerance. ChIP‐Seq expression target genes analysis showed could directly regulate related cell wall biosynthesis which...
Flowering time is an important agronomic trait that determines the distribution and adaptation of plants. The accurate prediction flowering in elite germplasm critical for maize breeding. However, molecular mechanisms underlying photoperiod response remain elusive maize. Here we cloned time-controlling gene, ZmNF-YC2, by map-based cloning confirmed ZmNF-YC2 nuclear transcription factor Y subunit C-2 protein a positive regulator under long-day conditions. Our results show promotes expression...
Abstract Pancreatic cancer (PC) development faces significant metabolic stress due to reprogramming and a distinct hypovascular nature, often leading glucose glutamine depletion. However, the adaption mechanisms by which PC adapts these challenges have not yet been completely explored. Here, we found that induced deprivation led an overexpression of ZNFX1 antisense RNA 1 (ZFAS1). This played role in instigating cell epithelial–mesenchymal transition (EMT) metastasis. Mechanistically, ZFAS1...
Abstract The majority of long non-coding RNAs (lncRNAs) have been discovered to be overexpressed in pancreatic cancer (PC) and served as promoters the tumorigenesis PC, while inhibitory functions lncRNAs development PC not fully elucidated yet. LncRNA microarray was adopted analyze differential expression tissues that normal peritumoral (NP) tissues. Functional role lncRNA BM466146.1 on evaluated by gain- loss-of-function experiments vivo vitro. RNA pull-down, immunoprecipitation, luciferase...
Macrophages are the most abundant alternative immune cells in tumor microenvironment (TME). The cross-talk between macrophages and provides an important shelter for occurrence development of tumors. As information transfer medium, exosomes play role intercellular communication. Nonetheless, how exosomal lncRNAs coordinate communication hepatocellular carcinoma (HCC) is incompletely understood. We found that HCC exosomes-derived antisense RNA SLC16A1(SLC16A1-AS1) promoted malignant...
Abstract Leaf angle is an important agronomic trait in cereals and shares a close relationship with crop architecture grain yield. Although it has been previously reported that ZmCLA4 can influence leaf angle, the underlying mechanism remains unclear. In this study, we used Gal4-LexA/UAS system transactivation analysis to demonstrate maize (Zea mays) transcriptional repressor regulates angle. DNA affinity purification sequencing (DAP-Seq) revealed mainly binds promoters containing EAR motif...
Resistance to sorafenib remains a major challenge in the systemic therapy of liver cancer. However, involvement lipid metabolism-related lncRNAs this process unclear.
The objectives of this study were to investigate the HRQoL residents living in central urban areas (CUA) and developing neighborhoods (DN) North-China examine relationship between health conditions physical mental components quality life.A stratified random sample was taken survey scoring system questionnaire SF-36 used conduct among community two selected districts 10 cities. A general also administered with questions that collected information, population demographic characteristics...