A5071963147- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- RNA modifications and cancer
- COVID-19 and healthcare impacts
- Genetic factors in colorectal cancer
- FOXO transcription factor regulation
- Sinusitis and nasal conditions
- Pancreatic and Hepatic Oncology Research
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Diet and metabolism studies
- Tryptophan and brain disorders
- Epigenetics and DNA Methylation
- Abdominal Surgery and Complications
- Infectious Diseases and Mycology
- Congenital gastrointestinal and neural anomalies
- Appendicitis Diagnosis and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer, Stress, Anesthesia, and Immune Response
- Circular RNAs in diseases
- Hedgehog Signaling Pathway Studies
- Sirtuins and Resveratrol in Medicine
- Intraperitoneal and Appendiceal Malignancies
Huazhong University of Science and Technology
2016-2025
Union Hospital
2016-2025
Union Hospital
2015-2024
Zhongkai University of Agriculture and Engineering
2023
Wuhan Union Hospital
2023
Abstract Background Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several epithelial cancers and closely associated with poor prognosis. However, the role of TM4SF1 its potential mechanism colorectal cancer (CRC) remain elusive. Methods We investigated expression Oncomine, Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases confirmed results by immunohistochemistry (IHC), qPCR Western blotting (WB) CRC tissues. The effect on epithelial-to-mesenchymal...
Cancer stem cells (CSCs), a rare population in any type of cancers, including colon cancer, are tumorigenic. It has been thought that CSCs responsible for cancer recurrence, metastasis, and drug resistance. Isolating cancers is challenging, thus the molecular mechanism regulating self-renewing differentiation remains unknown. We cultured DLD-1 cells, one types derived from serum-free medium to obtain spheroid cells. These possessed characteristics CSCs, with expression CD133, CD166, Lgr5,...
Glycolysis is a pivotal process in metabolic reprogramming of tumorigenesis. Previous research has indicated that lncRNAs might play crucial roles glycolysis various tumors. However, the function pancreatic cancer not been fully elucidated.Bio-information analyses were applied to reveal potential glycolysis-associated lncRNA. RT-PCR and fluorescence situ hybridization (FISH) assays detect expression antisense RNA1 DICER1 (DICER1-AS1) tissues cell lines. Gain- loss-of-function experiments...
Abstract Background Research has indicated that long-term sleep deprivation can lead to immune dysfunction and participate in the occurance progression of tumors. However, relationship between colon cancer remains unclear. This study explored specific mechanism through which promotes proliferation migration cancer, with a focus on neurotransmitter GABA. Methods Chronic mice model were used investigate effect disorder We detected levels peripheral blood using ELISA. CCK-8 assay, colony...
Platelet-derived growth factor-D (PDGF-D) plays a crucial role in the progression of several cancers. However, its colorectal cancer (CRC) remains unclear. Our study showed that PDGF-D was highly expressed CRC tissues and positively associated with clinicopathological features. Down-regulation inhibited tumor growth, migration angiogenesis SW480 cells vitro vivo. Whereas up-regulation promoted malignant behaviors HCT116 cells. Moreover, up-regulated expression Notch1 Twist1 In addition,...
Background/Aims: Although EpCAM+CD44+ cells exhibit more stem-like properties than did EpCAM-CD44- cells, the specificity of EpCAM combined with CD44 in defining CSCs needs further improvement. Lgr5 is used as a biomarker to isolate cancer stem (CSCs) colorectal cancer. However, it remains unclear whether Lgr5, along and CD44, can identify define Methods: Lgr5+CD44+EpCAM+, Lgr5+CD44+EpCAM-, Lgr5+CD44-EpCAM+, Lgr5-CD44+EpCAM+, Lgr5-CD44-EpCAM-cells were separately isolated using...
Rationale: PLAGL2 (pleomorphic adenoma gene like-2), a zinc finger PLAG transcription factor, is aberrantly expressed in several malignant tumors. However, the biological roles of and its underlying mechanism gastric cancer (GC) remain unclear. Methods: A series experiments vitro vivo were conducted to reveal role GC progression. Results: The data revealed that promotes cell proliferation, migration, invasion, EMT vivo. Mechanistically, we demonstrated critical stabilization snail family...
There is growing evidence that sleep deprivation promotes cancer progression. In addition, colon patients often experience due to factors such as pain and side effects of treatment. The occurrence liver metastases an important factor in the mortality patients. However, relationship between from has not been elucidated. A metastasis model was constructed evaluate effect on cancer. Subsequently, mice feces were collected for untargeted metabolomics screen identify key mediator, Kynurenic acid...
Abstract Background We previously demonstrated that the pleomorphic adenoma gene like-2 (PLAGL2) is involved in pathogenesis of Hirschsprung disease. Enhanced PLAGL2 expression was observed several malignant tumours. However, exact function and its underlying mechanism colorectal cancer (CRC) remain largely unknown. Methods Immunohistochemical analysis performed. A series vitro vivo experiments were conducted to reveal role progression CRC. Results significantly associated with EMT-related...
Evidence has shown that microRNAs (miRNAs) participate in the progression of CRC. Previous studies have indicated miR-214-3p is abnormally expressed various malignant tumors. However, biological function it plays CRC and potential mechanism are unclear. Here, we demonstrated was obviously downregulated Moreover, found a strong correlation between level tumor size lymphatic metastasis. Furthermore, when decreased by an Lv-miR-214-3p inhibitor, proliferation migration SW480 HCT116 cells were...
Nuclear factor I/B ( NFIB ) is a widely studied transcription that participates in tumor progression; nevertheless, studies on colorectal cancer CRC are limited. In our study, Western blot and RT ‐ PCR analyses showed was overexpressed tissues cell lines, which consistent with bioinformatic analysis results. Furthermore, expression closely related to the TNM stage of . promoted proliferation migration inhibited apoptosis vitro. Meanwhile, we discovered accelerated xenograft growth vivo....
The miR-214 has been reported to be associated with various diseases, but its involvement in the pathophysiology of Hirschsprung disease (HSCR) is almost completely unexplored. In our study, we conducted a series experiments unravel biological role HSCR. qRT-PCR and western blotting were utilized investigate relative expression levels miR-214, mRNAs, proteins related genes colon tissues from 20 controls without HSCR 24 patients potential two cell lines (SKN-SH SH-SY5Y) was assessed using...
Rationale: Previous studies have reported on the role of extracellular acidity in metastasis numerous cancers. However, involvement long noncoding RNA (lncRNA) acidity-induced cancer pancreatic (PC) remains unclear. Methods: Different expression levels lncRNAs PC cells under normal and acidic conditions were compared by sequencing (RNA-seq). The effects antisense lncRNA suppressor 1 (MTSS1-AS) assessed gain- loss-of-function experiments. Fluorescence situ hybridization, immunoprecipitation,...
Colorectal cancer (CRC) has been one of the most common types for decades worldwide. The pathogenesis CRC is associated with processes activating oncogenes and inactivating anti-oncogenes. Platelet-derived growth factor-D (PDGF-D) was confirmed to regulate migration, invasion, proliferation, apoptosis metastasis in various cells. Overexpression PDGF-D exists a number human malignancies, including pancreatic, prostate breast cancer. However, expression function its molecular mechanism remain...
Accurately predicting survival in patients with early hepatocellular carcinoma (HCC) is essential for making informed decisions about treatment and prognosis. Herein, we have developed a machine learning (ML) model that can predict patient guide decisions. We obtained demographic information, tumor characteristics, details from the SEER database. To analyze data, employed Cox proportional hazards (CoxPH) as well 3 ML algorithms: neural network multitask logistic regression (N-MLTR),...
The aim of this study was to evaluate the effects fermented feed on growth performance, antioxidant indexes and intestinal health in lion-head goslings.288 male goslings (one-day-old) were randomly divided into four groups (6 replicates per group, 12 samples replicate): control group (basal diet) (FF) diet supplemented with 2.5, 5.0 7.5% FF, respectively). experimental period lasted 28 days.The results showed that FF decreased conversion rate (FCR) when compared (p < 0.05). 5.0% reduced...
During the COVID-19 outbreak, some patients with pneumonia also suffered from acute abdomen requiring surgical treatment; however, there is no consensus for treatment of such patients. In this study, we retrospectively reviewed 34 who underwent emergency surgery during outbreak. Among abdomen, a total six cases were found (clinical classification pneumonia: all common type). On premise similar demographics between both groups, had worse indicators liver and coagulation function. Compared...
Sufficient conditions are obtained for the existence of positive periodic solution following discrete commensal symbiosis model with Holling II functional response $$ x_1(k+1)&=& x_1(k)\exp\Big\{ a_1(k)-b_1(k)x_1(k)+\di\frac{c_1(k)x_2(k)}{e_1(k)+f_1(k)x_2(k)}\Big\}, x_2(k+1)&=& x_2(k)\exp\big\{ a_2(k)-b_2(k)x_2(k)\big\}, where $ \{b_{i}(k)\}, i=1, 2, \{c_1(k)\} \{e_1(k)\}, \{f_1(k)\} all $\omega$-periodic sequences, $\omega is a fixed integer, $\{a_{i}(k)\}$ which satisfies...