A5101925613- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Genetic factors in colorectal cancer
- Cancer-related molecular mechanisms research
- COVID-19 Clinical Research Studies
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Long-Term Effects of COVID-19
- Congenital gastrointestinal and neural anomalies
- RNA modifications and cancer
- Transplantation: Methods and Outcomes
- COVID-19 and healthcare impacts
- Nanoparticle-Based Drug Delivery
- FOXO transcription factor regulation
- Neuropeptides and Animal Physiology
- Hedgehog Signaling Pathway Studies
- Diverse Scientific Research Studies
- Wnt/β-catenin signaling in development and cancer
- Dendrimers and Hyperbranched Polymers
- Sirtuins and Resveratrol in Medicine
- Enhanced Recovery After Surgery
- Thermal Regulation in Medicine
- Colorectal Cancer Surgical Treatments
- Epigenetics and DNA Methylation
- Therapeutic Uses of Natural Elements
Huazhong University of Science and Technology
2012-2023
Union Hospital
2012-2023
Union Hospital
2022
See Covering the Cover synopsis on page 2019. Because of accumulating evidence pointing to continuous person-to-person transmission coronavirus disease 2019 (COVID-19) in hospital and family settings,1Chan J.F. et al.Lancet. 2020; 395: 514-523Abstract Full Text PDF PubMed Scopus (6268) Google Scholar,2Phan L.T. al.N Engl J Med. 382: 872-874Crossref (825) Scholar World Health Organization has recently declared COVID-19 a public health emergency international concern. Fever respiratory...
Abstract Background Transmembrane 4 L six family member 1 (TM4SF1) is upregulated in several epithelial cancers and closely associated with poor prognosis. However, the role of TM4SF1 its potential mechanism colorectal cancer (CRC) remain elusive. Methods We investigated expression Oncomine, Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases confirmed results by immunohistochemistry (IHC), qPCR Western blotting (WB) CRC tissues. The effect on epithelial-to-mesenchymal...
Platelet-derived growth factor-D (PDGF-D) plays a crucial role in the progression of several cancers. However, its colorectal cancer (CRC) remains unclear. Our study showed that PDGF-D was highly expressed CRC tissues and positively associated with clinicopathological features. Down-regulation inhibited tumor growth, migration angiogenesis SW480 cells vitro vivo. Whereas up-regulation promoted malignant behaviors HCT116 cells. Moreover, up-regulated expression Notch1 Twist1 In addition,...
Abstract Background Previous studies have indicated that chronic emotional stressors likely participate in the occurrence of cancers. However, direct evidence connecting stress and colorectal cancer development remains almost completely unexplored. Methods Chronic mouse model was used to investigate influence on tumorigenesis. Several major agonists antagonists adrenergic receptors were applied effects β-adrenergic signaling CRC. Chromatin immunoprecipitation assays (CHIP) binding p53 CEBPB...
Abstract Background We previously demonstrated that the pleomorphic adenoma gene like-2 (PLAGL2) is involved in pathogenesis of Hirschsprung disease. Enhanced PLAGL2 expression was observed several malignant tumours. However, exact function and its underlying mechanism colorectal cancer (CRC) remain largely unknown. Methods Immunohistochemical analysis performed. A series vitro vivo experiments were conducted to reveal role progression CRC. Results significantly associated with EMT-related...
Evidence has shown that microRNAs (miRNAs) participate in the progression of CRC. Previous studies have indicated miR-214-3p is abnormally expressed various malignant tumors. However, biological function it plays CRC and potential mechanism are unclear. Here, we demonstrated was obviously downregulated Moreover, found a strong correlation between level tumor size lymphatic metastasis. Furthermore, when decreased by an Lv-miR-214-3p inhibitor, proliferation migration SW480 HCT116 cells were...
Nuclear factor I/B ( NFIB ) is a widely studied transcription that participates in tumor progression; nevertheless, studies on colorectal cancer CRC are limited. In our study, Western blot and RT ‐ PCR analyses showed was overexpressed tissues cell lines, which consistent with bioinformatic analysis results. Furthermore, expression closely related to the TNM stage of . promoted proliferation migration inhibited apoptosis vitro. Meanwhile, we discovered accelerated xenograft growth vivo....
The miR-214 has been reported to be associated with various diseases, but its involvement in the pathophysiology of Hirschsprung disease (HSCR) is almost completely unexplored. In our study, we conducted a series experiments unravel biological role HSCR. qRT-PCR and western blotting were utilized investigate relative expression levels miR-214, mRNAs, proteins related genes colon tissues from 20 controls without HSCR 24 patients potential two cell lines (SKN-SH SH-SY5Y) was assessed using...
Transplant arteriosclerosis is a leading cause of late allograft loss. Medial smooth muscle cell (SMC) apoptosis considered to be an important event in transplant arteriosclerosis. However, the precise contribution medial SMC and underlying mechanisms remain unclear. We transferred wild-type p53 induce cultured SMCs. found that induces production SDF-1α from apoptotic neighboring viable cells, resulting increased culture media. Conditioned media Ltv-p53-transferred SMCs activated...
Colorectal cancer (CRC) has been one of the most common types for decades worldwide. The pathogenesis CRC is associated with processes activating oncogenes and inactivating anti-oncogenes. Platelet-derived growth factor-D (PDGF-D) was confirmed to regulate migration, invasion, proliferation, apoptosis metastasis in various cells. Overexpression PDGF-D exists a number human malignancies, including pancreatic, prostate breast cancer. However, expression function its molecular mechanism remain...
In recent years, much attention has been given to liposomal formulation as an efficient drug loading system (DDS) in chemotherapy of cancer. this study, the advantages magnetic nanoparticles and Polyethylene Glyco (PEG) materials were considered synthesize gemcitabine long-circulating liposomes (MGLL) potential MGLL a brand new delivery was evaluated. prepared using reverse-phase evaporation method. optimized preparation, had average diameter 201 nm with narrow size distribution measured by...
The aim of the present study was to investigate association between mitogen-activated protein kinase (MAPK) signal transduction pathway and multidrug resistance in hepatocellular carcinoma cells. A Cell Counting Kit-8 assay used determine drug sensitivity HepG2 HepG2/ADM cell lines combination with MAPK/extracellular-signal-regulated (MEK) inhibitor U0126. Flow cytometry analyze rate apoptosis. reverse transcription-quantitative polymerase chain reaction (RT-qPCR) P-glycoprotein (P-gp)...
Since December 2019, the novel coronavirus has spread worldwide, affecting more than 510 million people, with 6 deaths. However, some of potential effects pandemic have not been thoroughly studied. We collected data from 2 regional emergency centers May to November for years 2015 before pandemic, and 2020, after pandemic. evaluated incidence each major type digestive disease in adults at hospitals, which experienced 2019 outbreaks varying severity. A total 11,394 patients were enrolled study...
The patients undergoing laparoscopic radical colorectomy in many Chinese hospitals do not achieve high compliance with the ERAS (enhanced recovery programs after surgery) protocol.The clinical data from 1,258 were collected and divided into non-ERAS incomplete groups.A total of 1,169 screened for inclusion. After propensity score-matched analysis (PSM), 464 pairs well-matched generated comparative study. Incomplete reduced incidence postoperative complications (p = 0.002), both mild (6.7%...