A5101901783- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- TGF-β signaling in diseases
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Research and Treatments
- Liver physiology and pathology
- Enhanced Recovery After Surgery
- Gastrointestinal disorders and treatments
- Wnt/β-catenin signaling in development and cancer
- Chemokine receptors and signaling
- Transplantation: Methods and Outcomes
- Cancer, Hypoxia, and Metabolism
- Endometriosis Research and Treatment
- Congenital Heart Disease Studies
- PI3K/AKT/mTOR signaling in cancer
- Nitric Oxide and Endothelin Effects
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related gene regulation
- Neurological Disease Mechanisms and Treatments
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Uterine Myomas and Treatments
Fujian Provincial Cancer Hospital
2014-2024
Fujian Medical University
2017-2024
University of Alabama at Birmingham
2018
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
Colorectal cancer is one of the most common malignancies worldwide. Liver metastasis major direct cause colorectal cancer-related deaths. Although radical resection effective treatment for liver metastasis, several patients are not eligible surgery. Therefore, there a need to develop novel treatments based on understanding biological mechanisms underlying in cancer. This study demonstrated that activin A/ACVR2A inhibits colon cell migration and invasion, as well suppresses...
Abstract Background Despite current advances in gastric cancer treatment, disease metastasis and chemo-resistance remain as major hurdles against better overall prognosis. Previous studies indicated that IGHG1 well -Catenin serve important regulators of tumor cellular malignancy. Therefore, understanding detailed molecular mechanism identifying druggable target will be great potentials future therapeutic development. Methods Surgical tissues cell lines were retrieved to evaluate expression...
Negative lymph node (NLN) count has been validated as a protective predictor in various cancers after radical resection. However, the prognostic value of NLN setting stage IV gastric cancer patients who have received palliative resection not investigated. Surveillance, Epidemiology, and End Results Program (SEER)-registered were used for analysis this study. Kaplan-Meier survival curves multivariate Cox proportional hazards model to assess risk factors patients' survivals. The results showed...
Cyclic shedding of the endometrium is unique to menstruating species. The status decidua in mouse menstrual-like models seems differ from that predecidua humans before endometrial breakdown. aim this study was determine how difference decidual related A model generated by pharmacological progesterone withdrawal. Histomorphological analysis and reticular fiber staining were used evaluate status. In situ zymography localization active collagenase gelatinase. functional layer containing mature...
Background Gastric gastrointestinal stromal tumors in challenging anatomical locations are difficult to remove. Methods This study retrospectively analyzed the clinical data of 12 patients with gastric GISTs who underwent robot-assisted laparoscopic combined endoscopic partial gastrectomy (RALE-PG) and manual suturing wall. Results included a mean age 56.8 ± 9.8 years BMI 23.9 1.9 kg/m 2 . Tumors were located GEJ ( n = 3), lesser curvature posterior wall 3) antrum 3). The cardia pylorus...
Colorectal cancer (CRC) is one of the most common cancers in world. Due to its preferential metastasis liver, CRC has become leading causes cancer-related deaths worldwide. There evidence showing that a variety subpopulations exist among cells, which play an important role liver metastasis. Growing suggests CD133 and C-X-C chemokine receptor type 4 (CXCR-4) are thought contribute progression However, it not been fully characterized CRC. Here, we found expression CXCR4 metastatic tissues was...
The patients undergoing laparoscopic radical colorectomy in many Chinese hospitals do not achieve high compliance with the ERAS (enhanced recovery programs after surgery) protocol.The clinical data from 1,258 were collected and divided into non-ERAS incomplete groups.A total of 1,169 screened for inclusion. After propensity score-matched analysis (PSM), 464 pairs well-matched generated comparative study. Incomplete reduced incidence postoperative complications (p = 0.002), both mild (6.7%...
Background: Cancer stem cells (CSCs) are a type of tumor cell that self-sustaining and can differentiate into several different types cells. The present study aims to investigate the effect hematopoietic progenitor (HPCs) on biological behavior colon CSCs (CCSCs) determine underlying molecular mechanisms liver metastasis in colorectal cancer. Methods: Subsets CCSCs were isolated from stem-like HCT116 cocultured with CD133+ HPCs vitro. Colony formation assay, CCK-8 used assess effects CCSC...