A5100765848- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Radiomics and Machine Learning in Medical Imaging
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Epigenetics and DNA Methylation
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Cancer, Stress, Anesthesia, and Immune Response
- Kruppel-like factors research
- Wnt/β-catenin signaling in development and cancer
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Advancements in Transdermal Drug Delivery
- Cancer Risks and Factors
- HVDC Systems and Fault Protection
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
Fujian Medical University
2023-2025
Union Hospital
2022-2025
Fujian Provincial Hospital
2024-2025
Guang’anmen Hospital
2024-2025
Fujian Provincial People's Hospital
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Huazhong University of Science and Technology
2020-2024
Xi’an Jiaotong-Liverpool University
2024
Fuzhou University
2024
First Affiliated Hospital of Fujian Medical University
2024
Female-specific cancers, particularly breast, cervical, ovarian, and uterine account for nearly 40% of all cancers in women. This study aimed to analyze the global epidemiological trends these from 1990 2021, offering insights into their evolving patterns providing valuable information health policymakers allocate healthcare resources more effectively. Data Global Burden Disease Study 2021 (GBD 2021) were used comprehensively assess incidence, mortality, disability-adjusted life years...
Accelerated cell cycle progression is the common feature of most cancers. MiRNAs can act as oncogenes or tumor suppressors by directly modulating machinery. It has been shown that miR-188 upregulated in UVB-irradiated mouse skin and human nasopharyngeal carcinoma CNE cells under hypoxic stress. However, little known about function proliferation growth control.Overexpression inhibits proliferation, colony formation G1/S transition cells. Using bioinformatics approach, we identify a series...
Most data on mortality and prognostic factors of universal healthcare waiting lists come from North America, Australasia, Europe, with little information South America. We aimed to determine the relationship between medical center-specific time list in Chile. Using all new patients listed specialist waitlists for non-prioritized health problems 2008 2015 three geographically distant regions Chile, we constructed hierarchical multivariate survival models predict risk at two years after...
Accumulating evidence strongly suggests that hyperglycemia promotes the progression of pancreatic cancer (PC). Approximately 80% patients with PC are intolerant to hyperglycemic conditions. In this study, we define role Bmi1, a stemness-related oncogene, in controlling Warburg effect, and immune suppression under conditions.The diabetes mellitus model was established by intraperitoneal injection streptozotocin. The hyperglycemia-Bmi1-HK2 axis glycolysis-related immunosuppression examined...
Abstract Pancreatic ductal adenocarcinomas (PDAC) is one of the stiffest malignancies with strong solid stresses. Increasing stiffness could alter cellular behavior and trigger internal signaling pathways strongly associated a poor prognosis in PDAC. So far, there has been no report on an experimental model that can rapidly construct stably maintain gradient dimension both vitro vivo. In this study, gelatin methacryloyl (GelMA)‐based hydrogel was designed for vivo PDAC experiments. The...
Song Zhen, Anxin Zhang, Jie Luo, Guanghai Xiong, Haibo Peng, Rang Zhou, Yuanfeng Li, Hongqiang Xu, Zhen Wei Zhao, and Haoxiang Zhang. Prevalence of high-altitude polycythemia hyperuricemia risk factors for in immigrants. High Alt Med Biol. 24:132–138, 2023. Background: Few studies have investigated the epidemiology chronic mountain sickness (CMS) This study evaluated prevalence (HUA) HUA Methods: A cross-sectional was conducted with 7,070 immigrants 15–45 years age living on Tibetan Plateau...
Background Infective Endocarditis (IE) and Sepsis are two closely related infectious diseases, yet their shared pathogenic mechanisms at the transcriptional level remain unclear. This research gap poses a barrier to development of refined therapeutic strategies drug innovation. Methods study employed collaborative approach using both microarray data single-cell RNA sequencing (scRNA-seq) identify biomarkers for IE Sepsis. It also offered an in-depth analysis roles regulatory patterns immune...
Background: The efficacy of laparoscopic completion total gastrectomy (LCTG) for remnant gastric cancer (RGC) remains controversial. Methods: primary outcome was postoperative morbidity within 30 days after surgery. Secondary outcomes included 3-year disease-free survival (DFS), overall (OS), and recurrence. Inverse probability treatment weighted (IPTW) used to balance the baseline between LCTG OCTG. Results: Final analysis 46 patients with RGC who underwent at FJMUUH June 2016 2020....
Curcumin (CM) has multiple pharmacological activities including anti-fungal activity, but its clinical application is limited due to low solubility in aqueous media, poor bioavailability and extensive first pass metabolism. We aimed resolve the limitation enhance antifungal activity of CM using nanotechnology. Using silk fibroin (SF) as a carrier, we fabricated curcumin-silk nanoparticles (CM-SF NPs) by solution enhanced dispersion supercritical CO₂ (SEDS) technique. The characterization...
Neoadjuvant immunotherapy has been shown to improve survival in patients with gastric cancer. This study sought develop and validate a radiomics-based machine learning (ML) model for locally advanced cancer (LAGC), specifically predict whether will achieve major pathological response (MPR) following neoadjuvant immunotherapy. With its predictive capabilities, this tool shows promise enhancing clinical decision-making processes the future. utilized multicenter cohort design, retrospectively...
Hypoxia is a general event in solid tumor growth. Therefore, induced cellular responses by hypoxia are important for tumorigenesis and MicroRNAs (miRNAs) have recently emerged as regulators of responses. Here we report that miR-147a novel crucial miRNA. HIF-1α up-regulates the expression miR-147a, turn stabilizes accumulates protein via directly targeting HIF-3α, dominant negative regulator HIF-1α. Subsequent studies xenograft mouse model reveal capable inhibiting Collectively, these data...
Abstract Background Nearly 80% of patients with pancreatic cancer suffer from glucose intolerance or diabetes. Pancreatic complicated by diabetes has a more immunosuppressive tumor microenvironment (TME) and is associated worse prognosis. The relationship between metabolism programmed cell death-Ligand 1 (PD-L1) close complex. It important to explore the regulation high on PD-L1 expression in its effect infiltrating immune effectors microenvironment. Methods Diabetic murine models (C57BL/6)...