A5074161936- Soft Robotics and Applications
- Robotics and Sensor-Based Localization
- Gastrointestinal Bleeding Diagnosis and Treatment
- Surgical Simulation and Training
- Genetic factors in colorectal cancer
- Nutrition and Health in Aging
- Advanced Vision and Imaging
- ECG Monitoring and Analysis
- Cancer Genomics and Diagnostics
- Pancreatitis Pathology and Treatment
- Nutritional Studies and Diet
- Augmented Reality Applications
- Diet and metabolism studies
- Esophageal and GI Pathology
- Robotic Path Planning Algorithms
- Immune Response and Inflammation
- EEG and Brain-Computer Interfaces
- Frailty in Older Adults
- Cancer-related gene regulation
- Ginseng Biological Effects and Applications
- Artificial Intelligence in Healthcare and Education
- Inorganic Chemistry and Materials
- Modular Robots and Swarm Intelligence
- PI3K/AKT/mTOR signaling in cancer
- Piezoelectric Actuators and Control
Fujian Medical University
2017-2025
Chinese University of Hong Kong
2021-2025
Prince of Wales Hospital
2023
Chinese Academy of Sciences
2013
•This is the first phase III trial comparing SCRT followed by immunochemotherapy to LCRT chemotherapy in LARC.•Neoadjuvant CAPOX and camrelizumab significantly improved pCR versus neoadjuvant CAPOX.•Neoadjuvant demonstrated promising efficacy LARC patients with pMMR/MSS.•The treatment arm provides opportunity for organ preservation a watch-and-wait strategy.•No unexpected toxicities were observed, safety profile of was manageable. BackgroundNeoadjuvant short-course radiotherapy (SCRT) (a...
Objectives The global prevalence of diabetes is continuously rising, and the gut microbiota closely associated with it. Dietary Index for Gut Microbiota (DI-GM) assesses impact diet on microbiota, but its association risk remains unclear. This study aims to investigate between DI-GM analyze mediating roles phenotypic age body mass index (BMI). Methods Utilizing data from National Health nutrition examination survey (NHANES) 1999–2018, we included 17,444 adults aged 20 years older. (score...
Chemotherapy is one of the most commonly used treatments for patients with advanced colon cancer, yet toxicity chemotherapy agents, such as 5‑fluorouracil (5‑FU), limits effectiveness chemotherapy. Ginsenoside Rg3 (Rg3) an active ingredient isolated from ginseng. has been shown to display anticancer effects on a variety malignancies. Yet, whether synergizes effect 5‑FU inhibit growth human cancer remains unknown. The present study was designed ascertain able enhance anti‑colon 5‑FU. results...
This study investigated the relationship between frailty index and all-cause cause-specific mortality in patients with depression. We recruited 2,669 participants depression from National Health Nutrition Examination Survey (NHANES) 2005 to 2018 quantified their status using a 53-item index. Cox proportional hazards models were used estimate hazard ratios (HR) 95% confidence intervals (CI). The median (IQR) score was 0.3 (0.2, 0.4). During follow-up of 7.1 years, 342 deaths (including 85...
Background Acute pancreatitis (AP) is a prevalent gastrointestinal emergency with wide spectrum of clinical outcomes, varying from mild cases to severe forms. The early identification high-risk patients essential for improving prognosis. However, the predictive and prognostic potential C-reactive protein serum calcium ratio (CCR) in AP has not been investigated. This study aims explore association between CCR disease severity AP. Methods retrospective cross-sectional included 476 patients....
Cancer survivors may experience accelerated biological aging, increasing their risk of mortality. However, the association between phenotypic age acceleration (PAA) and mortality among cancer remains unclear. This study aimed to evaluate relationship PAA all-cause mortality, cancer-specific non-cancer adult in United States. We utilized data from National Health Nutrition Examination Survey (NHANES) 1999 2018, including 2,643 (unweighted) patients aged ≥ 20 years. Phenotypic was calculated...
Objective The relationship between constipation and anxiety remains underexplored. This study investigates the association in a representative sample of adults United States. Methods A cross-sectional analysis was conducted using data from National Health Nutrition Examination Survey (NHANES) 2007 to 2010, including 9,126 aged ≥20 years. Constipation were assessed standardized survey instruments. Multivariable logistic regression models employed calculate adjusted odds ratios (ORs), subgroup...
This letter presents the first case of implementing deep-learning based instrument tracking on a magnetic anchored surgical endoscope. The compact actuated endoscope has unique structure that allows operations near anchor surface, ideal for video assisted thoracoscopic surgery (VATS). Autonomous tool alleviates surgeon's burden and prevents human errors from muscle fatigues or miscommunication. However, conventional methods rely color labels require modification to instrument, risk failure...
In minimally invasive surgery, endoscopes serve as the eyes of surgeon. To avoid fatigue in manual endoscope steering, robotic holders have been developed. Unfortunately, existing are not widely adopted due to poor surgeon-robot cooperation. this work, we developed an intelligent flexible system based on da Vinci Research Kit. system, surgical instruments detected and classified real time with oriented bounding box-based object detection method. A custom dataset 6243 images is established...
Endoscopes provide views inside the patient's body during minimally invasive surgery. Although various robotic endoscopes have been developed to reduce surgeons' workload in manual endoscope operations, autonomous manipulation remains challenging due misorientation effect and different disturbances. In this work, we an intelligent system steer surgical view automatically. To keep target (i.e., tip of instrument) at center camera with a suitable size orientation, image moment-based...
Conventional colonoscopy using a flexible colonoscope remains two major limitations, including patient discomfort and difficult manipulations for surgeons. Robotic colonoscopes have been developed to conduct in patient-friendly manner. However, most robotic still maintain nonintuitive manipulations, which limits their clinical applications. In this paper, we demonstrated visual servo-based semi-autonomous of an electromagnetic actuated soft-tethered (EAST) colonoscope, aims lower...
Redundant systems are highly favored due to their superior performance. However, rapid real-time solutions, state variable constraints, and noise-resistance of redundant still challenging issues be solved. Therefore, a novel noise-resistant adaptive gain zeroing neural network (NRAG-ZNN) is designed handle time-varying system problems with it successfully applied flexible endoscope robot (RFER) visual tracking. First, tracking control scheme error, joint position, velocity constraints based...
The increasing global prevalence of ulcerative colitis (UC) underscores the imperative to explore novel therapeutic approaches. Traditional Chinese medicine has historically shown potential in addressing this ailment. current study aimed elucidate functional attributes and underlying mechanisms isofraxidin, a coumarin derivative from Acanthopanax, context UC. A murine model dextran sodium sulfate (DSS)-induced UC was established, we conducted comprehensive assessment influence isofraxidin on...
This study aims to elucidate the role and mechanisms of Death Receptor 6 (DR6), a member tumor necrosis factor receptor superfamily, in malignant progression colorectal cancer (CRC). The association DR6 expression levels CRC patient survival was examined using cohort data from GEPIA database. functional cells investigated by performing loss-of-function gain-of-function experiments based on CCK-8 proliferation assay, transwell migration invasion sphere-forming assays. Xenograft model nude...
Abstract Background Despite current advances in gastric cancer treatment, disease metastasis and chemo-resistance remain as major hurdles against better overall prognosis. Previous studies indicated that IGHG1 well -Catenin serve important regulators of tumor cellular malignancy. Therefore, understanding detailed molecular mechanism identifying druggable target will be great potentials future therapeutic development. Methods Surgical tissues cell lines were retrieved to evaluate expression...
In minimally invasive surgery (MIS), the field of view (FOV) plays a vital role. To enhance stability FOV and lighten burden on surgeons, robot-assisted laparoscope systems have been developed introduced into surgery. However, most existing automatic surgical tool tracking schemes with robotic laparoscopes either do not consider depth direction or remote center motion (RCM) constraints. tackle these problems, this article presents an autonomous three-dimensional instrument framework for...
Breast cancer is the most common in women. The tumor prone to metastasize brain, lung, liver, bone, and other organs; however, generally, it less likely digestive tract. Thus, breast metastasizes colon rarely happened easily ignored by clinicians. Such misdiagnosis may lead delay further diagnosis treatment of patients, or even cause life danger patients due progress disease. Therefore, we propose such case reports arouse clinicians' attention rare tract metastasis after cancer. We also...
In this paper, we proposed an autonomous robotic flexible endoscope system for the laparoscopic bariatric surgery (LBS). This comprises a UR5 robot and equipped with novel continuum joint, named reinforced double helix mechanism. Compared simple structure, compressional torsional stiffness of joint are improved significantly. To automate endoscope, image-based visual servoing technique is employed. A deep learning algorithm TernausNet-16 incorporated into control framework to detect surgical...
This study evaluates the relationship between Life's Essential 8 (LE8) scoring system and all-cause cause-specific mortality among obese individuals using National Health Nutrition Examination Survey data. Data from 9143 participants (BMI ≥30 kg/m2) collected 2005 2018 were analyzed. Participants categorized based on their LE8 scores: low cardiovascular health (Low CVH, n = 2264), moderate (Moderate 6541), high (High 338). Associations scores assessed Kaplan-Meier survival analysis Cox...