A5036424416- Microbial Natural Products and Biosynthesis
- Pancreatitis Pathology and Treatment
- Appendicitis Diagnosis and Management
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Estrogen and related hormone effects
- Molecular Communication and Nanonetworks
- Electrochemical Analysis and Applications
- Cardiovascular Health and Risk Factors
- Gastrointestinal disorders and treatments
- Healthcare cost, quality, practices
- Muscle and Compartmental Disorders
- Psoriasis: Treatment and Pathogenesis
- Cancer Genomics and Diagnostics
- Medicinal Plant Pharmacodynamics Research
- Chemotherapy-related skin toxicity
- Orthopedic Surgery and Rehabilitation
- Virus-based gene therapy research
- Protein Degradation and Inhibitors
- Health disparities and outcomes
- Gastrointestinal Tumor Research and Treatment
- Water Quality and Pollution Assessment
- Surgical Sutures and Adhesives
- Calpain Protease Function and Regulation
- Circular RNAs in diseases
Fujian Medical University
2024-2025
Inner Mongolia Medical University
2025
Northwestern University
2013-2024
Jiangnan University
2024
State Key Laboratory of Food Science and Technology
2024
Southern Medical University
2022-2024
Beijing Academy of Science and Technology
2022-2023
Uppsala University
2022
Xiamen University
2022
Guangzhou Medical University
2014-2021
Ruthenium(II) polypyridyl complexes have emerged both as promising probes of DNA structure and anticancer agents because their unique photophysical cytotoxic properties. A key consideration in the administration those therapeutic is optimization chemical reactivities to allow facile attack on target sites, yet avoid unwanted side effects. Here, we present a drug delivery platform technology, obtained by grafting surface mesoporous silica nanoparticles (MSNPs) with ruthenium(II)...
Background: The C-reactive protein/lymphocyte ratio (CLR) is a prognostic biomarker of various diseases. However, its significance in acute pancreatitis (AP) remains unknown. main aim this study was to investigate the association between CLR and disease severity patients with AP. Methods: This cross-sectional included 476 AP (mild (MAP), n =176; moderately severe (MSAP) (SAP), n=300). primary exposure interest baseline CLR. outcome incidence moderate Multivariate logistic regression...
Objectives The global prevalence of diabetes is continuously rising, and the gut microbiota closely associated with it. Dietary Index for Gut Microbiota (DI-GM) assesses impact diet on microbiota, but its association risk remains unclear. This study aims to investigate between DI-GM analyze mediating roles phenotypic age body mass index (BMI). Methods Utilizing data from National Health nutrition examination survey (NHANES) 1999–2018, we included 17,444 adults aged 20 years older. (score...
Diabetes mellitus is associated with systemic damage across multiple organ systems, and an increasing number of patients are presenting diabetic kidney disease as its initial manifestation. The onset progression nephropathy closely podocyte injury. Sodium-glucose cotransporter type 2 (SGLT2) inhibitors, which can significantly reduce glucose levels well protecting against damage, therefore widely used for the clinical treatment disease. An body research has revealed that renal protective...
Abstract Apatinib was the first anti-angiogenic agent approved for treatment of metastatic gastric cancer (GC). However, emergence resistance inevitable. Thus investigating new and valuable off-target effect apatinib directly against cells is great significance. Here, we identified extra spindle pole bodies-like 1 (ESPL1) responsible in GC through CRISPR genome-wide gain-of-function screening. Loss function studies further showed that ESPL1 inhibition suppressed cell proliferation, migration...
Background Acute pancreatitis (AP) is a prevalent gastrointestinal emergency with wide spectrum of clinical outcomes, varying from mild cases to severe forms. The early identification high-risk patients essential for improving prognosis. However, the predictive and prognostic potential C-reactive protein serum calcium ratio (CCR) in AP has not been investigated. This study aims explore association between CCR disease severity AP. Methods retrospective cross-sectional included 476 patients....
Long non-coding ribonucleic acids (lncRNAs) are a class of RNAs implicated in the development many malignancies, including gastric cancer (GC). In this study, we investigated functions and molecular mechanisms RNA activated by deoxyribonucleic acid damage (NORAD) GC.NORAD expression at messenger levels was determined quantitative reverse transcriptase (RT)-polymerase chain reaction assays. Cell proliferation, migration, invasion were detected Counting Kit-8 assays, in-vivo tumor formation...
This study evaluates the relationship between Life's Essential 8 (LE8) scoring system and all-cause cause-specific mortality among obese individuals using National Health Nutrition Examination Survey data. Data from 9143 participants (BMI ≥30 kg/m2) collected 2005 2018 were analyzed. Participants categorized based on their LE8 scores: low cardiovascular health (Low CVH, n = 2264), moderate (Moderate 6541), high (High 338). Associations scores assessed Kaplan-Meier survival analysis Cox...
The high carbon intensity of present-day ethylene glycol (EG) production motivates interest in electrifying oxidation. Noting poor kinetics prior reports the organic electrooxidation small hydrocarbons, we explored design mediators that activate and simultaneously stabilize light alkenes. A ruthenium-substituted polyoxometalate (Ru-POM, {Si[Ru(H
Background: This study sought to test the effectiveness of EVOSKIN®Palm and sole moisturizing cream (PSMC) in preventing treating hand-foot syndrome (HFS) during capecitabine chemotherapy.Methods: Stage II/III colorectal cancer patients receiving adjuvant chemotherapy were randomly allocated receive either EVOSKINPSMC or physiological saline treatments for their hands feet. Treatment was initiated along with continued till end chemotherapy. Participants' skin responses evaluated every...
Mass spectrometry-based dereplication and prioritization led to the discovery of four multi-N-methylated cyclodecapeptides, auyuittuqamides E–H (1–4), from a soil-derived Sesquicillium sp. The planar structures these compounds were elucidated based on analysis HRESIMS NMR data. Absolute configurations chiral amino acid residues assigned by combination advanced Marfey's method, chiral-phase LC-MS analysis, J-based configuration revealing that 1–4 contain both d- l-isomers N-methylleucine...
Background: Colonoscopy, a crucial diagnostic tool in gastroenterology, depends heavily on superior bowel preparation. ChatGPT, large language model with emergent intelligence which also exhibits potential medical applications. This study aims to assess the accuracy and consistency of ChatGPT using Boston Bowel Preparation Scale (BBPS) for colonoscopy assessment. Methods: We retrospectively collected 233 images from 2020 2023. These were evaluated BBPS by 3 senior endoscopists novice...
This study aimed to evaluate the effects of <em>Bifidobacterium breve</em> CCFM683 on psoriasis and investigate underlying mechanisms. significantly ameliorated in mice as well elevated deoxycholic acid (DCA) lithocholic (LCA) colon compared with those imiquimod-treated mice. Meanwhile, <em>B. increased relative abundance DCA-producing <em>Lachnoclostridium</em> diminished harmful <em>Desulfovibrio</em> <em>Prevotellaceae </em>UCG001. Additionally, farnesoid X receptor (FXR) skin was...
Gallstone disease is one of the most common gastrointestinal disorders. Despite extensive research exploring risk factors associated with gallstones, association between depressive symptoms and gallstones remains inadequately understood. This study aimed to assess prevalence among adults in United States.
A 60-year-old male with increasing abdominal distension was admitted to The Fifth Affiliated Hospital of Guangzhou Medical University (Guangzhou, China). sonogram exhibited a huge cystic-based mass solid components in the left upper quadrant. contrast-enhanced computed tomography scan abdomen revealed large heterogeneous cystic tumor, but source tumor could not be determined. laparotomy demonstrated an integrated wall, arising from posterior wall gastric body. Multiple septa and ~3,500 ml...
Dexterity is an essential characteristic of pneumatic soft grippers for robust grasping objects. However, the traditional are difficult to grasp objects in a stable manner due inferiority dexterity. Inspired by multi-knuckle structure human fingers, finger, composed three independent-actuated segments, proposed enable dexterous manipulation. Compared with conventional single-chamber finger possesses larger travelling space (the maximum execution range 90.34 mm at x-axis), tunable output...
Different formative pluripotent stem cells are recently established harboring similar functional properties of lineage neutral and germline competence yet with distinct molecular identities. Here, we show that WNT/β-catenin signaling activation can sustain transient mouse epiblastlike as epiblast-like (EpiLSCs). EpiLSCs display metastable pluripotency bivalent cellular energy metabolism unique transcriptomic features chromatin accessibility. We develop scSTALT to study continuum revealed...