A5057091058- Cellular Mechanics and Interactions
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Tendon Structure and Treatment
- Virus-based gene therapy research
- TGF-β signaling in diseases
- Spaceflight effects on biology
- RNA Interference and Gene Delivery
- Vibration Control and Rheological Fluids
- Urban Heat Island Mitigation
- Wnt/β-catenin signaling in development and cancer
- Hippo pathway signaling and YAP/TAZ
- Advanced biosensing and bioanalysis techniques
- Muscle Physiology and Disorders
- Magnetic Bearings and Levitation Dynamics
- Cancer-related gene regulation
- Remote Sensing and Land Use
- Connective Tissue Growth Factor Research
- Sport and Mega-Event Impacts
- Gear and Bearing Dynamics Analysis
- Building Energy and Comfort Optimization
- Tribology and Lubrication Engineering
- Wind and Air Flow Studies
- Nuclear Structure and Function
- Cancer, Hypoxia, and Metabolism
Chongqing University
2016-2025
Chinese Academy of Fishery Sciences
2025
Ministry of Agriculture and Rural Affairs
2025
Sichuan University
2010-2025
Karolinska Institutet
2022-2025
Wuhan University of Technology
2025
Zhaoqing University
2024
State Key Laboratory of Mechanical Transmission
2024
Mahasarakham University
2024
Children's Hospital of Chongqing Medical University
2005-2023
Pluripotent mesenchymal stem cells (MSCs) are bone marrow stromal progenitor that can differentiate into osteogenic, chondrogenic, adipogenic, and myogenic lineages. Several signaling pathways have been shown to regulate the lineage commitment terminal differentiation of MSCs. Here, we conducted a comprehensive analysis 14 types morphogenetic protein (BMPs) for their abilities multilineage specific We found most BMPs exhibited distinct expression Runx2, Sox9, MyoD, PPARgamma2. Further...
Osteoblast lineage-specific differentiation of mesenchymal stem cells is a well regulated but poorly understood process. Both bone morphogenetic proteins (BMPs) and Wnt signaling are implicated in regulating osteoblast formation. Here we analyzed the expression profiles stimulated with Wnt3A osteogenic BMPs, identified connective tissue growth factor (CTGF) as potential target BMP signaling. We confirmed microarray results, demonstrated that CTGF was up-regulated at early stage BMP-9...
Marrow mesenchymal stem cells are pluripotent progenitors that can differentiate into bone, cartilage, muscle, and fat cells. Wnt signaling has been implicated in regulating osteogenic differentiation of Here, we analyzed the gene expression profile were stimulated with Wnt3A. Among 220 genes whose was significantly changed by 2.5-fold, found three members CCN family, CCN1/Cyr61, CCN2/connective tissue growth factor (CTGF), CCN5/WISP2, among most up-regulated genes. We further investigated...
Abstract Efficient osteogenic differentiation and bone formation from mesenchymal stem cells (MSCs) should have clinical applications in treating nonunion fracture healing. MSCs are adherent marrow stromal that can self-renew differentiate into osteogenic, chondrogenic, adipogenic, myogenic lineages. We identified morphogenetic protein 9 (BMP-9) as one of the most BMPs. Here we investigate effect insulin-like growth factor 2 (IGF-2) on BMP-9-induced formation. found endogenous IGF-2...
Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily and play an important role in development many cellular processes. We have found that BMP-2, BMP-6, BMP-9 induce most potent osteogenic differentiation of mesenchymal stem cells. Expression profiling analysis has revealed Inhibitors DNA binding/differentiation (Id)-1, Id-2, Id-3 are among significantly up-regulated genes upon or stimulation. Here, we sought determine functional these Id BMP-induced osteoblast differentiation....
Mesenchymal stem cells (MSCs) are non-hematopoietic with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin.MSCs can osteoblastic, chondrogenic, adipogenic lineages, although recent studies have demonstrated that MSCs also able other including neuronal cardiomyogenic lineages.Since their original isolation from bone marrow, been successfully harvested many tissues.Their ease ex vivo expansion combined immunoprivileged nature has made these popular...
Mesenchymal stem cells (MSCs) are bone marrow stromal that can differentiate into multiple lineages. We previously demonstrated BMP9 is one of the most potent BMPs to induce osteogenic differentiation MSCs. least studied BMPs. Whereas ALK1, ALK5, and/or endoglin have recently been reported as potential type I receptors in endothelial cells, little known about receptor involvement BMP9-induced Here, we conduct a comprehensive analysis functional role seven signaling found expressed However,...
Promoting osteogenic differentiation and efficacious bone regeneration have the potential to revolutionize treatment of orthopaedic musculoskeletal disorders. Mesenchymal Stem Cells (MSCs) are marrow progenitor cells that capacity differentiate along osteogenic, chondrogenic, myogenic, adipogenic lineages. Differentiation these lineages is a tightly controlled process in part regulated by Bone Morphogenetic Proteins (BMPs). BMPs 2 7 been approved for clinical use because their osteoinductive...
As one of the most common malignancies, colon cancer is initiated by abnormal activation Wnt/β-catenin pathway. Although treatment options have increased for some patients, overall progress has been modest. Thus, there a great need to develop new treatments. We found that bisbenzylisoquinoline alkaloid tetrandrine (TET) exhibits anticancer activity. TET used as calcium channel blocker treat hypertensive and arrhythmic conditions in Chinese medicine. Here, we investigate molecular basis...
Amplifying intracellular oxidative stress effectively destroys cancer cells. In addition, iron-mediated Fenton reaction converts endogenous H2O2 to produce hypertoxic hydroxyl radical (•OH), resulting in irreversible damage combat tumor This method is known as chemodynamic therapy (CDT). Overexpressed glutathione (GSH) cells efficiently scavenges •OH, significantly reducing the curative effects of CDT. To overcome this challenge and enhance stress, iron oxide nanocarriers loaded with...
Background As one of the least studied bone morphogenetic proteins (BMPs), BMP9 is most osteogenic BMPs. Retinoic acid (RA) signaling known to play an important role in development, differentiation and metabolism. In this study, we investigate effect RA on BMP9-induced mesenchymal progenitor cells (MPCs). Methodology/Principal Findings Both primary MPCs MPC line are used for stimulation. Recombinant adenoviruses deliver BMP9, RARα RXRα into MPCs. The vitro monitored by determining early late...
Abstract Growth hormone (GH) is usually released by somatotrophs in the anterior pituitary response to GH-releasing and plays an important role skeleton development postnatal growth. However, it unclear if extrapituitary GH exerts any effect on murine multilineage cells (MMCs). MMCs are multipotent progenitors that give rise several lineages, including bone, cartilage, fat. We have identified bone morphogenic protein 9 (BMP9) as one of most osteogenic BMPs regulating a distinct set...
Abstract Microgravity induces observed bone loss in space flight and reduced osteogenesis of mesenchymal stem cells (BMSCs) partly contributes to this phenomenon. Abnormal regulation or functioning the actin cytoskeleton induced by microgravity may cause inhibited BMSCs, but underlying mechanism remains obscure. In study, we demonstrated that cytoskeletal changes regulate nuclear aggregation transcriptional coactivator with PDZ-binding motif (TAZ), which is indispensable for (BMSCs)....
Increased extracellular matrix (ECM) stiffness and metabolic reprogramming of cancer cells are two fundamental mediators tumor progression, including hepatocellular carcinoma (HCC). Yet, the correlation between ECM excessive aerobic glycolysis in promoting development HCC remains unknown. Here, we demonstrated that stiffer promotes cell migration depending on their accelerated glycolysis. Our results also indicated ECM-induced YAP activation plays a major role cells. Moreover, showed JNK p38...
Mesenchymal stem cells (MSCs) are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes, chondrocytes, adipocytes, tenocytes myocytes. MSCs represent one of the most commonly-used adult serve as excellent progenitor cell models for investigating lineage-specific differentiation regulated by various cellular signaling pathways, such bone morphogenetic proteins (BMPs). As members TGFβ superfamily, BMPs play diverse...
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Osteosarcoma is the most common primary malignancy of bone. The long-term survival osteosarcoma patients hinges on our ability to prevent and/or treat recurrent and metastatic lesions. Here, we investigated activation peroxisome proliferator-activated receptor gamma (PPARgamma) retinoid receptors as a means differentiation therapy for human osteosarcoma.We examined endogenous expression PPARgamma in panel cells. Ligands or adenovirus-mediated overexpression these were tested inhibit...