A5080963878- Bone health and osteoporosis research
- Thyroid and Parathyroid Surgery
- Parathyroid Disorders and Treatments
- Bone and Joint Diseases
- Thyroid Cancer Diagnosis and Treatment
- Hip and Femur Fractures
- Medical Imaging and Analysis
- Nutrition and Health in Aging
- Vitamin D Research Studies
- Bone Metabolism and Diseases
- Genetic Syndromes and Imprinting
- Radiomics and Machine Learning in Medical Imaging
- Bone health and treatments
- Body Composition Measurement Techniques
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Electrolyte and hormonal disorders
- Congenital heart defects research
- Vitamin C and Antioxidants Research
- Pelvic and Acetabular Injuries
- Advanced X-ray and CT Imaging
- COVID-19 Clinical Research Studies
- Bone fractures and treatments
- Medical Coding and Health Information
- Radiation Dose and Imaging
University of Chicago
2015-2024
University of California, San Diego
2024
University of Illinois Chicago
2008-2021
<h3>Importance</h3> Vitamin D treatment has been found to decrease the incidence of viral respiratory tract infection, especially in patients with vitamin deficiency. Whether is associated coronavirus disease 2019 (COVID-19) unknown. <h3>Objective</h3> To examine whether last status before COVID-19 testing test results. <h3>Design, Setting, and Participants</h3> This retrospective cohort study at an urban academic medical center included a 25-hydroxycholecalciferol or...
Pluripotent mesenchymal stem cells (MSCs) are bone marrow stromal progenitor that can differentiate into osteogenic, chondrogenic, adipogenic, and myogenic lineages. Several signaling pathways have been shown to regulate the lineage commitment terminal differentiation of MSCs. Here, we conducted a comprehensive analysis 14 types morphogenetic protein (BMPs) for their abilities multilineage specific We found most BMPs exhibited distinct expression Runx2, Sox9, MyoD, PPARgamma2. Further...
Understanding the etiology, diagnosis, and symptoms of hypoparathyroidism may help to improve quality life long-term disease outcomes. This paper summarizes results findings recommendations Working Group on Presentation Hypoparathyroidism.Experts convened in Florence, Italy, May 2015 evaluated literature recent data presentation outcomes patients with hypoparathyroidism.The most frequent etiology is surgical removal or loss viability parathyroid glands. Despite precautions expertise, about...
Vitamin D treatment has been found to decrease incidence of viral respiratory tract infection, especially in vitamin deficiency. It is unknown whether COVID-19 associated with deficiency and treatment.To examine are testing positive for COVID-19.Retrospective cohort study Setting: University Chicago Medicine Participants: Patients tested from 3/3/2020-4/10/2020. was defined by the most recent 25-hydroxycholecalciferol <20ng/ml or 1,25-dihydroxycholecalciferol <18pg/ml within 1 year before...
Deficient (ie, <20 ng/mL) or insufficient 20 to <30 25-hydroxyvitamin D (also known as calcifediol) levels are more common in Black individuals than White and associated with increased coronavirus disease 2019 (COVID-19) risk. Whether COVID-19 risk is differences vitamin of 30 ng/mL greater not known.
Reduced health-related quality of life (HRQoL) is common in patients with hypoparathyroidism treated conventionally calcium and active vitamin D supplements.To examine the effects recombinant human parathyroid hormone [rhPTH(1-84)] on HRQoL as measured by 36-Item Short-Form Health Survey (SF-36) during a multinational, randomized, placebo-controlled study.Adults (N = 122) chronic hypoparathyroidism.After an optimization period when and/or supplements were adjusted to reach target serum...
Abstract Context Conventional hypoparathyroidism treatment with oral calcium and active vitamin D is aimed at correcting hypocalcemia but does not address other physiologic defects caused by PTH deficiency. Objective To evaluate long-term safety tolerability of recombinant human (1-84) [rhPTH(1-84)]. Design Open-label extension study; 5-year interim analysis. Setting 12 US centers. Patients Adults (N = 49) chronic hypoparathyroidism. Intervention(s) rhPTH(1-84) 25 or 50 µg/d initially, 25-µg...
Hypoparathyroidism is characterized by insufficient levels of parathyroid hormone (PTH). TransCon PTH an investigational long-acting prodrug PTH(1-34) for the treatment hypoparathyroidism.This work aimed to investigate safety, tolerability, and efficacy daily in adults with phase 2, randomized, double-blind, placebo-controlled 4-week trial open-label extension enrolled 59 individuals hypoparathyroidism. Interventions included 15, 18, or 21 µg PTH(1-34)/day placebo 4 weeks, followed a 22-week...
The relationship of visceral adipose tissue (VAT) and subcutaneous (SAT) with bone mineral density (BMD) is not well established.To examine the associations VAT SAT total body BMD in a large, nationally representative population wide range adiposity.We analyzed 10 641 subjects aged 20 to 59 years National Health Nutrition Examination Survey 2011-2018 who had undergone measured by dual-energy X-ray absorptiometry. Linear regression models were fitted while controlling for age, sex, race or...
In hypoparathyroidism, inappropriately low levels of parathyroid hormone lead to unbalanced mineral homeostasis. The objective this study was determine the effect recombinant human hormone, rhPTH(1–84), on phosphate and vitamin D metabolite in patients with hypoparathyroidism. Following pretreatment optimization calcium doses, 124 a phase III, 24-week, randomized, double-blind, placebo-controlled adults hypoparathyroidism received subcutaneous injections placebo or rhPTH(1–84) (50 µg/day,...
Conventional therapy for hypoparathyroidism consisting of active vitamin D and calcium aims to alleviate hypocalcemia but fails restore normal parathyroid hormone (PTH) physiology. PTH replacement is the ideal physiologic treatment hypoparathyroidism. The double-blind, placebo-controlled, 26-week, phase 3 PaTHway trial assessed efficacy safety individuals with investigational drug TransCon (palopegteriparatide). Participants (n = 84) were randomized 3:1 once-daily (initially 18 μg/d) or...
Abstract Context The effect of high levels obesity on bone health are not clear. Objective We aimed to examine the associations body composition and mineral density (BMD) in a large, nationally representative population with wide range mass index. Methods analyzed 10 814 subjects aged 20-59 from NHANES 2011-2018 who had total BMD data. Body was examined as lean index (LMI) fat (FMI). Linear regression models were created outcome, while examining LMI FMI controlling for age, gender,...
Conventional therapy for hypoparathyroidism aims to alleviate symptoms of hypocalcemia but does not address insufficient parathyroid hormone (PTH) levels.
Changes in osmoregulation during normal menstrual cycle were examined 15 healthy women. In 10 women, studied repetitively two consecutive cycles, basal plasma osmolality, sodium, and urea decreased by 4 mosmol/kg, 2 meq/l, 0.5 mM, respectively (all P less than 0.02) from the follicular to luteal phase. Plasma vasopressin, protein, hematocrit, mean arterial pressure, body weight did not change. five other diluting capacity osmotic control of thirst vasopressin release assessed follicular,...