A5046034725- Antibiotics Pharmacokinetics and Efficacy
- Thyroid and Parathyroid Surgery
- Antibiotic Resistance in Bacteria
- Parathyroid Disorders and Treatments
- Bacterial Identification and Susceptibility Testing
- Skin and Cellular Biology Research
- Nail Diseases and Treatments
- Antibiotic Use and Resistance
- Antimicrobial Resistance in Staphylococcus
- Autoimmune Bullous Skin Diseases
- Thyroid Cancer Diagnosis and Treatment
- Cardiovascular Syncope and Autonomic Disorders
- Neutropenia and Cancer Infections
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Lysosomal Storage Disorders Research
- Glycogen Storage Diseases and Myoclonus
- Vitamin D Research Studies
- Bacillus and Francisella bacterial research
- Contact Dermatitis and Allergies
- Advancements in Transdermal Drug Delivery
- Pharmaceutical Practices and Patient Outcomes
- Genetically Modified Organisms Research
- Sexual function and dysfunction studies
- Neuroendocrine Tumor Research Advances
Crinetics Pharmaceuticals (United States)
2024
Amicus Therapeutics (United States)
2017-2020
Takeda (United States)
2016
University of Minnesota Medical Center
2004-2005
Solvay (Belgium)
2004-2005
University of Michigan
2004-2005
Orange County Heart Institute and Research Center
2004-2005
State University of New York
2004-2005
Solvay (United States)
2004
European Centre for Ecotoxicology and Toxicology of Chemicals
1995
ABSTRACT Hypoparathyroidism is a rare endocrine disorder whose incidence and prevalence have not been well defined. This study aimed to 1) estimate the number of insured adult patients with hypoparathyroidism in United States 2) obtain physician assessment disease severity chronicity. Prevalence was estimated through calculation diagnoses large proprietary health plan claims database over 12-month period from October 2007 September 2008 projected US population. Incidence also calculated same...
Abstract Background Little information is available regarding the burden of living with and managing epidermolysis bullosa, including distinct challenges faced by patients different disease types/subtypes. Methods A 90-question/item survey was developed to collect demographics, diagnostic data, management practices, illness for bullosa in United States. Recruitment conducted via email social media partnership patient advocacy organizations States, telephone interview a third-party health...
Empirical therapy with cefoperazone was compared plus amikacin in granulocytopenic and nongranulocytopenic febrile patients. In nonneutropenic patients the overall response rate to 88%; 10 of 12 gram-negative bacteremic were cured. Cefoperazone resulted an 88% cured 14 15 bacteremia. neutropenic 77% alone 73% amikacin; cure rates for bacteremias 8 11 6 patients, respectively. Our findings support concept single-drug empirical cancer whether or not, especially when are predominantly caused by...
The bactericidal activity of rifampin plus other antibiotics was examined with in vitro checkerboard dilutions against 15 strains staphylococci, time-kill studies, and determinations serum activities (SBAs) volunteers. In synergism found consistently only inhibitory assays minocycline. Time-kill studies methicillin revealed enhanced killing at concentrations close to the MBC but reduced combined higher concentrations. SBAs rifampin, oxacillin, two drugs combination were studied three...
Teicoplanin was evaluated in 47 patients with severe infections, including 14 bone 11 soft-tissue 7 endocarditis, 5 pneumonia, 3 septic thrombophlebitis, septicemia of unknown origin, and 4 miscellaneous infections. Overall, bacteremia documented 24 patients. The pathogens isolated were 35 strains Staphylococcus aureus (including 8 methicillin-resistant strains), epidermidis, Streptococcus faecalis, 2 pneumoniae, other streptococci, 1 Micrococcus luteus strain. A total 22 (46.8%) clinically...
In hypoparathyroidism, inappropriately low levels of parathyroid hormone lead to unbalanced mineral homeostasis. The objective this study was determine the effect recombinant human hormone, rhPTH(1–84), on phosphate and vitamin D metabolite in patients with hypoparathyroidism. Following pretreatment optimization calcium doses, 124 a phase III, 24-week, randomized, double-blind, placebo-controlled adults hypoparathyroidism received subcutaneous injections placebo or rhPTH(1–84) (50 µg/day,...
BackgroundImpaired mineral homeostasis affecting calcium, phosphate, and magnesium is a result of parathyroid hormone (PTH) deficiency in hypoparathyroidism. The current standard treatment with active vitamin D oral calcium does not control levels these major minerals. Recombinant full-length human PTH 1–84 (rhPTH[1–84]) being developed for the hypoparathyroidism.ObjectiveThe goal this study was to investigate pharmacokinetics pharmacodynamics single subcutaneous injection rhPTH(1–84)...
Sera of volunteers receiving ceftazidime (2 g) or amikacin (500 mg), alone in combination, cefoperazone (2, 4, 6 with mg) were evaluated for bactericidal activity against Klebsiella pneumoniae and Pseudomonas aeruginosa. Serum activities similar plus amikacin, but definitely lower alone. Against P. aeruginosa, a 6-g dose resulted higher frequency peak serum greater than equal to 1:8 2-g amikacin. Killing studies, performed diluted serum, demonstrated killing rate cefoperazone, the more...
Abstract Disclosure: R.J. Auchus: Consulting Fee; Self; Corcept Therapeutics, H Lundbeck A/S, Quest Diagnostics, Sparrow Pharmaceuticals, Neurocrine Biosciences, Novo Nordisk, Recordati Rare Diseases, Diurnal, Xeris Pharmaceuticals. Research Investigator; Adrenas Spruce Biosciences. P.J. Trainer: Employee; Crinetics Inc.. Stock Owner; K.J. Lucas: None. D. Bruera: J. Marko: Inc. A. Ayala: Y. Wu: C.T. Ferrara-Cook: E. De La Torre: Krasner: H. Lagast: R. Luo: Pharmaceuticals T.A. Bachega: R.S....
The authors evaluated, in a community‐based open‐label trial, the effectiveness and safety of perindopril 13,220 US hypertensive patients studied how physicians adhere to hypertension treatment guidelines. Patients received 4 mg q.d. for 6 weeks. Based on physicians' perception blood pressure response, patient was either maintained or dose increased 8 an additional From baseline week 12, mean sitting significantly declined from 156.9/94.5 mm Hg 139.2/84.0 Hg. Further titration resulted...
Teicoplanin (0.2 g) or vancomycin (1 were infused over 3 and 50 min respectively to six male volunteers in a cross-over study. Each drug was administered twice at 14 h interval. The pharmacokinetics of both drugs accurately described using two-compartment model. Vancomycin had shorter half-life (5.8±1.8 h) compared teicoplainin (33.2±5.1h; P<0.001) One hour serum tested for bactericidal activity against ten strains each Staphylococcus aureus (median 1:16 teicoplanin; 1:32 vancomycin), Staph....
A subgroup analysis of a large US community trial was conducted to evaluate the antihypertensive efficacy and safety perindopril, an angiotensin-converting enzyme inhibitor (ACEI), in 3159 patients who lacked blood pressure (BP) control at entry with previous therapy. Patients received 4 mg perindopril daily for 6 weeks. Based on physicians' assessment BP response, were then either maintained (group 1) or dose increased 8 2) additional The mean baseline sitting 158.2/92.9 mm Hg. Perindopril...
Abstract Background Epidermolysis bullosa (EB) is a rare genetic disorder that manifests as blistering and/or skin erosion. There no approved treatment for EB; current standard of care consists wound and pain management. SD-101 6% topical cream containing allantoin was developed treating lesions in patients with EB. The aim this phase 3, multicenter, randomized, double-blind, vehicle-controlled study to assess the efficacy safety versus vehicle (0% allantoin) on Methods Eligible were ≥1...
Chronic wounds are a fundamental issue for patients with epidermolysis bullosa (EB). Herein, we assess the natural history of wound closure in EB who were randomly assigned to vehicle-control arm multicenter, randomized, double-blind, phase 3 ESSENCE (NCT02384460) trial.ESSENCE was designed efficacy and safety topical cream formulation 6% allantoin (SD-101 6%) vs vehicle 0%) ≥1 month old had diagnosis (simplex, recessive dystrophic, or intermediate junctional) target 10-50 cm2 present ≥21...
Journal Article Bactericidal activity of ciprofloxacin in serum and urine against Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus Streptococcus faecalis Get access H. Lagast, Lagast Service de Médecine et Laboratoire d'Investigation Clinique Tagnon, Institut Jules Bordet, Centre des Tumeurs I'Université Libre Bruxelles1, rue Héger-Bordet, 1000 Bruxelles, Belgium Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Husson,...
Abstract Background Fabry disease is a progressive X-linked lysosomal disorder. In this subgroup analysis of the global phase III ATTRACT study, efficacy and safety oral migalastat, pharmacologic chaperone, were investigated in Japanese patients with disease. Methods Patients randomly assigned to receive migalastat (150 mg every other day) or continue biweekly enzyme replacement therapy infusions (ERT; agalsidase alfa 0.2 mg/kg beta 1.0 mg/kg) for 18 months followed by 12-month open-label...
Serum bactericidal activity against 20 strains of Pseudomonas aeruginosa was studied in 10 volunteers after administration imipenem (25 mg/kg), mg/kg) plus amikacin (7.5 and ceftazidime mg/kg). Eight were susceptible 12 resistant to ticarcillin. levels measured microbiologically 30 60 min were, respectively, 97 46 micrograms/ml for given alone 79 45 with amikacin. Despite the very large dose used, appeared slightly less active than (P or equal 0.1; Wilcoxon matched-pairs test), respective...
Timentin (ticarcillin plus clavulanic acid) amikacin was administered as an empirical regimen to 52 febrile granulocytopenic patients with cancer and appeared effective the other commonly recommended combinations of antimicrobial agents. A favourable response observed in 61% episodes bacteraemia 83% without bacteraemia. However, efficacy Gram-positive suboptimal emergence superinfections caused by cocci may represent a clinical challenge.
Serum bactericidal activity was determined against 10 strains each of Pseudomonas aeruginosa and Staphylococcus aureus in serum from volunteers 1 6 h after intravenous infusion cefotaxime, tobramycin, the combination; or moxalactam, combination. High P. found significantly more frequently with moxalactam plus tobramycin than alone cefotaxime tobramycin.