A5029530230- Antibiotic Use and Resistance
- Cystic Fibrosis Research Advances
- Appendicitis Diagnosis and Management
- Antibiotics Pharmacokinetics and Efficacy
- Antimicrobial Resistance in Staphylococcus
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- Infective Endocarditis Diagnosis and Management
- Antifungal resistance and susceptibility
- Neuroscience and Neuropharmacology Research
- Nosocomial Infections in ICU
- Streptococcal Infections and Treatments
- Nicotinic Acetylcholine Receptors Study
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Ion channel regulation and function
- Diverticular Disease and Complications
- Animal and Plant Science Education
- Silk-based biomaterials and applications
- Thyroid and Parathyroid Surgery
- American Environmental and Regional History
- Mycobacterium research and diagnosis
- Receptor Mechanisms and Signaling
- Invertebrate Taxonomy and Ecology
- Pneumonia and Respiratory Infections
The University of Texas Southwestern Medical Center
1994-2025
Southwestern Medical Center
2019-2025
Southwestern University
2025
Duke University
1998-2020
JPS Health Network
2016-2019
University of North Texas
2017-2019
University of North Texas System
2017-2019
University of North Texas Health Science Center
2017-2019
John Peter Smith Hospital
2016-2019
Health Net
2017-2019
Abstract Recent advances in understanding the epidemiology, genetics, diagnosis, clinical presentations, skeletal involvement, and therapeutic approaches to hypoparathyroidism led First International Workshop on Hypoparathyroidism that was held 2009. At this conference, a group of experts convened discuss these issues with view towards future research agenda for disease. This review, which focuses primarily adult, provides comprehensive summary latest information © 2011 American Society Bone...
Importance Practice guidelines often provide recommendations in which the strength of recommendation is dissociated from quality evidence. Objective To create a clinical guideline for diagnosis and management adult bacterial infective endocarditis (IE) that addresses gap between evidence strength. Evidence Review This consensus statement systematic review applied an approach previously established by WikiGuidelines Group to construct collaborative guidelines. In April 2022 call new existing...
The kainate receptor subunit KA2 does not form functional homomeric channels despite its structural similarity to the glutamate 5-7subunits and high agonist binding affinity in vitro assays. In this study, we first demonstrate that receptors fail reach plasma membrane then identify molecular mechanisms preventing surface expression. Specifically, show subunits homooligomeric are confined endoplasmic reticulum (ER). We that, both heterologous expression systems primary neurons, intracellular...
Kainate receptors (KARs) are mediators of excitatory neurotransmission in the mammalian central nervous system, and their efficient targeting trafficking is critical for normal synaptic function. A key step delivery KARs to neuronal plasma membrane exit newly assembled from endoplasmic reticulum (ER). Here we report identification a novel ER retention signal alternatively spliced C-terminal domain GluR5–2b subunit, which controls receptor both heterologous cells neurons. The motif consists...
Abstract Background The escalating prevalence of multidrug-resistant (MDR) Pseudomonas aeruginosa presents a serious threat to patient care due its limited treatment options. However, imipenem-cilastatin-relebactam (IMI/REL) is promising beta-lactam/beta-lactamase inhibitor combination with expanded activity against MDR P. aeruginosa. This study aimed explore the characteristics, efficacy and safety IMI/REL for infections aeruginosa.Table 1.Patient infection characteristics. Methods was...
Abstract Background: Patients discharged from emergency departments (ED) with antibiotics for common infections often receive unnecessarily prolonged durations, representing a target transition of care (TOC) antimicrobial stewardship intervention. Methods: This study aimed to evaluate the effectiveness TOC pharmacists’ review on decreasing duration discharge oral in patients ED at an academic medical center. Pharmacist interventions were guided by antibiotic therapy guidance focused...
Abstract Background Multidrug-resistant (MDR) Gram-negative infections are a substantial threat to patients and public health. Imipenem/cilastatin/relebactam (IMI/REL) is beta-lactam/beta-lactamase inhibitor with expanded activity against MDR Pseudomonas aeruginosa carbapenem-resistant Enterobacterales. This study aims describe the patient characteristics, prescribing patterns, clinical outcomes associated IMI/REL. Methods was retrospective, multicenter, observational of ≥18 years old who...
Abstract Introduction Patients with thermal injury undergo metabolic changes resulting in a hypermetabolic state, leading to altered pharmacokinetics antimicrobials, including tobramycin. Tobramycin efficacy is associated peak minimum inhibitory concentration (MIC) ratio of 8-10; thus, for an MIC 2, ideal tobramycin peaks are between 16-20 mcg/mL. Optimal dosing strategies those injuries undefined, as literature suggests large variations kinetics that may require higher doses compared...
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon possible after acceptance. Accepted have been peer-reviewed and copyedited, but are posted before technical formatting author proofing. These not final version record will be replaced with article (formatted per style proofed by authors) at a later time. A customized Epic scoring tool for monitoring medications requiring renal dose adjustment utilizing Bugsy custom function trend column was...
Kainate receptors show a particular affinity for variety of natural source compounds, including dysiherbaine (DH), potent agonist derived from the marine sponge <i>Dysidea herbacea</i>. In this study, we characterized pharmacological activity and structural basis subunit selectivity neodysiherbaine (neoDH) MSVIII-19, which are synthetic analogs DH, respectively. NeoDH MSVIII-19 differ DH in composition two functional groups that confer specificity ionotropic glutamate receptors. radioligand...
Intracellular trafficking of ionotropic glutamate receptors is regulated predominantly by determinants in the cytoplasmic C-terminal domain subunit proteins. Although AMPA are found at vast majority excitatory synapses, synaptic kainate exhibit a much more restricted distribution, suggesting that specific mechanisms exist for selective these receptor In this report, we define critical forward motif necessary surface expression 6 (GluR6) as well chimeric proteins containing only GluR6 domain....
Treatment options for nontuberculous mycobacteria (NTM) infections are limited by the pathogen's intrinsic resistance profile and toxicities. Tedizolid linezolid display in vitro activity against NTM species. However, safety data treatment outcomes solid organ transplant (SOT) population.This was a single-center retrospective cohort study of adult SOT recipients receiving or tedizolid an infection from January 1, 2010, to August 31, 2019. The primary outcome compared hematologic profiles vs...
On the basis of previous SAR findings and molecular modeling studies, a series compounds were synthesized which possessed various sulfonyl moieties substituted at 4-position C-3 phenyl ring substituent dihydropyran-2-one system. The substituents added in an attempt to fill additional S(3)' pocket thereby produce increasingly potent inhibitors target enzyme. Racemic enantiomerically resolved varieties selected synthesized. All analogues study displayed decent binding affinity HIV protease,...
Dysiherbaine (1) and its congener neodysiherbaine A (2) are naturally occurring excitatory amino acids with selective potent agonistic activity for ionotropic glutamate receptors. We describe herein the total synthesis of 2 structural analogues 3−8. Advanced key intermediate 16 was employed as a branching point to assemble series these 3−8 respect C8 C9 functionalities, which would not have been accessible through manipulations natural product itself. The features (i) stereocontrolled...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Structure and Total Synthesis of Cassaic Acid1,2Richard B. Turner, O. Buchardt, E. Herzog, R. Morin, A. Riebel, J. M. SandersCite this: Am. Chem. Soc. 1966, 88, 8, 1766–1775Publication Date (Print):April 1, 1966Publication History Published online1 May 2002Published inissue 1 April 1966https://pubs.acs.org/doi/10.1021/ja00960a034https://doi.org/10.1021/ja00960a034research-articleACS PublicationsRequest reuse permissionsArticle...
Antagonists for kainate receptors (KARs), a family of glutamategated ion channels, are efficacious in number animal models neuropathologies, including epilepsy, migraine pain, and anxiety. To produce molecules with novel selectivities receptors, we generated three sets analogs related to the natural marine convulsant neodysiherbaine (neoDH), characterized their pharmacological profiles. Radioligand displacement assays recombinant α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)...
Dysiherbaine (DH) and related molecules are high-affinity, subunit-selective kainate receptor (KAR) ligands originally isolated from a marine sponge. To elucidate why DH, an agonist, MSVIII-19, competitive antagonist, bind selectively to glutamate (GluR) 5 but not the KA2 KAR subunit, we used molecular dynamics simulations generate binding models that were tested experimentally in radioligand electrophysiological assays. Three candidate sites, Val685, Leu735, Ser741 GluR5, corresponding...
Enterococci are isolated frequently as pathogens in patients with intra-abdominal infections (IAIs) and may predict poor clinical outcomes. It remains controversial whether enterococci warrant an altered treatment approach regard to antimicrobial treatment.The study population was derived from the Study Optimize Peritoneal Infection Therapy (STOP-IT) trial database. Through post hoc analysis subjects were stratified into two groups based on isolation of Enterococcus. Fifty cohort (n = 518)...