A5042527142- Clostridium difficile and Clostridium perfringens research
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Nosocomial Infections in ICU
- Antibiotic Use and Resistance
- Microscopic Colitis
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune Cell Function and Interaction
- Thoreau and American Literature
- Neutropenia and Cancer Infections
- Fungal Infections and Studies
- Streptococcal Infections and Treatments
- Long-Term Effects of COVID-19
- Botulinum Toxin and Related Neurological Disorders
- Antifungal resistance and susceptibility
- Pharmacological Effects and Toxicity Studies
- Yersinia bacterium, plague, ectoparasites research
- Library Science and Administration
- Immune cells in cancer
University of Houston
2021-2025
Methodist Hospital
2020-2023
Epidemiologic studies have shown decreasing vancomycin susceptibility among clinical Clostridioides difficile isolates, but the impact on patient outcomes is unknown. We hypothesized that reduced would be associated with decreased rates of sustained response (SCR).
Antimicrobial resistance is emerging in clinical strains of
Abstract Delayed administration of active anti-infective therapy is associated with increased rates adverse events, mortality, and costs among sepsis patients. Inherent limitations conventional culture identification methods the lengthy turnaround time antimicrobial susceptibility testing are significant barriers to timely delivery life-saving therapy, particularly antibiotic-resistant infections. Culture-independent diagnostic techniques that detect pathogens resistance genes within...
ABSTRACT Background COVID-19 disease, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has spread globally, and no proven treatments are available. Convalescent plasma therapy been used with varying degrees of success to treat microbial infections for more than 100 years. Methods Patients ( n =25) and/or life-threatening disease were enrolled at the Houston Methodist hospitals from March 28 – April 14, 2020. transfused convalescent obtained donors confirmed SARS-CoV-2...
Abstract Background Carbapenem-resistant Enterobacterales (CRE) are a major public health threat due to increasing prevalence and limited effective treatment options. Meropenem/vaborbactam (M/V) is beta-lactam/beta-lactamase inhibitor agent designed treat CRE. There paucity of data related patient characteristics associated outcomes with the utilization M/V in pneumonia The objective this study was describe real-world experience setting. Methods This retrospective, observational,...
Abstract Background The escalating prevalence of multidrug-resistant (MDR) Pseudomonas aeruginosa presents a serious threat to patient care due its limited treatment options. However, imipenem-cilastatin-relebactam (IMI/REL) is promising beta-lactam/beta-lactamase inhibitor combination with expanded activity against MDR P. aeruginosa. This study aimed explore the characteristics, efficacy and safety IMI/REL for infections aeruginosa.Table 1.Patient infection characteristics. Methods was...
Abstract Background Ibezapolstat (IBZ) is Gram-positive selective spectrum antibiotic that inhibits the bacterial DNA polymerase IIIC currently in clinical trial development for treatment of C. difficile infection (CDI) adults. In open-label, non-comparative, phase 2a study, 10 IBZ-treated CDI patients experienced cure. The purpose 2b study was to assess safety, efficacy, and microbiome change IBZ versus vancomycin (VAN). Methods Phase (ClinicalTrials.gov, number NCT04247542) a randomized,...
Abstract Background C. difficile infection is unique in that the diagnosis made via identification of toxins stool rather than by bacterial growth. Therefore, strain typing and antibiotic susceptibility testing are not routinely performed on isolates. Instead, active surveillance programs required to identify new epidemic and/or antibiotic-resistant strains. The purpose this project was create a comprehensive, multistate program can quantify variability prevalence resistance across United...
Abstract Background Due to detection of Clostridioides difficile colonization, many hospitals changed from a PCR-based CDI diagnostic two-step using GDH/EIA assay. How this change affected the ecology C. strains or patient outcomes is unknown. The purpose study was assess differences in strain and after CDI-diagnostic Methods Stool samples considered positive by institutional policy were collected university-affiliated quaternary care hospital associated community 2016-21. cultured for...
Abstract Background Multidrug-resistant (MDR) Gram-negative infections are a substantial threat to patients and public health. Imipenem/cilastatin/relebactam (IMI/REL) is beta-lactam/beta-lactamase inhibitor with expanded activity against MDR Pseudomonas aeruginosa carbapenem-resistant Enterobacterales. This study aims describe the patient characteristics, prescribing patterns, clinical outcomes associated IMI/REL. Methods was retrospective, multicenter, observational of ≥18 years old who...
Abstract Background Reduced vancomycin (VAN) susceptibility in clinical Clostridioides difficile isolates is correlated with poor outcomes. However, factors associated infection these strains are unknown. The goal of this study was to determine risk for reduced VAN among C. difficile. Methods This multicenter cohort included adults (CDI) between 2016 and 2021. Clinical underwent agar dilution testing ribotyping. defined as a minimum inhibitory concentration (MIC) > 2 µg/mL. Medical...
Fulminant Clostridioides difficile infection (FCDI) is associated with a 30%-40% mortality rate. Guideline definitions for FCDI severity classification include ileus, megacolon, shock, or hypotension. However, no hypotension definition provided, making application of the challenging. The objective this study was to assess optimal criteria. This multicenter cohort involving 1172 hospitalized patients diagnosed C (CDI) from 2015 2022 (Houston cohort). Patients were assessed composite endpoint...
Abstract Background Ceftriaxone is frequently prescribed due to its convenience of dosing and robust antimicrobial activity. However, patients with hypoalbuminemia may experience suboptimal ceftriaxone exposure the high degree protein binding. We aimed evaluate impact on treatment failure among hospitalized adults Enterobacterales bacteremia who received therapy. Methods conducted an observational cohort study >72 hours initiated within 48 index culture. A propensity-score model was...
Vancomycin is not appreciably passaged via the colonic membrane to gastrointestinal (GI) tract in persons with an intact gut epithelium due its large chemical structure. However; hospitalized patients diarrhea often have a disrupted GI tract. The aim of this study was determine frequency detectable vancomycin concentrations stool antibiotic-associated receiving IV vancomycin. This multicenter cohort samples collected for Clostridioides difficile testing. Leftover were from who had received...
Mucormycosis is caused by ubiquitous fungi and encompasses a variety of different opportunistic syndromes in humans that disproportionately affect immunocompromised patients. Mortality has been documented to range between 50 100%; however, location infection greatly dictates likelihood survival. Treatment mucormycosis involves aggressive surgical intervention combination therapy antifungal agents. In solid organ transplant recipients, immunosuppressive agents used prevent rejection the...
Abstract Background Fulminant Clostridioides difficile infection (FCDI) is associated with high rates of mortality and morbidity; however, risk factors for FCDI are poorly understood. The objective this study was to identify clinical microbiological predictive FCDI. Methods This a multicenter cohort involving adult hospitalized patients diagnosed an incident case CDI (2015-22). Leftover stool samples were collected ribotyping determination binary toxin presence (CDT; assumed in ribotypes...