A5100403044- RNA modifications and cancer
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Bacterial Genetics and Biotechnology
- Bacterial biofilms and quorum sensing
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- Electrochemical Analysis and Applications
- Microbial infections and disease research
- Electrochemical sensors and biosensors
- RNA and protein synthesis mechanisms
- Liver Disease Diagnosis and Treatment
- Geomagnetism and Paleomagnetism Studies
- Epigenetics and DNA Methylation
- TGF-β signaling in diseases
- Free Radicals and Antioxidants
- Cancer-related gene regulation
- PI3K/AKT/mTOR signaling in cancer
- Cancer Research and Treatments
- Geochemistry and Elemental Analysis
- Magnetic and Electromagnetic Effects
- Muscle Physiology and Disorders
Shenzhen Institutes of Advanced Technology
2019-2025
Ministry of Agriculture and Rural Affairs
2023-2025
Nanjing Agricultural University
2023-2025
Chinese Academy of Sciences
2019-2025
First Affiliated Hospital of Henan University
2025
Zhejiang Chinese Medical University
2016-2025
Guizhou University
2024-2025
Ministry of Education of the People's Republic of China
2022-2024
Northwest University
2024
Gansu Agricultural University
2024
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Abstract Hepatic stellate cell (HSC) activation is considered as a central driver of liver fibrosis and effective suppression HSC contributes to the treatment fibrosis. Circular RNAs (circRNAs) have been reported be important in tumor progression. However, contributions circRNAs remain largely unclear. The fibrosis-specific circRNA was explored by microarray cVIM (a derived from exons 4 8 vimentin gene mmu_circ_32994) selected research object. Further studies revealed that cVIM, mainly...
Abstract Background Although metformin, a first-line drug for treating diabetes, may play an important role in inhibition of epithelial ovarian cancer cell growth and stem cells (CSCs), metformin at low dose showed less effect on the proliferation cells. In this study, we evaluated CSCs order to understand molecular mechanisms underlying. Methods The inhibitory effects los population including SKOV3 A2780 were assessed by assay flow cytometry. Quantitative real-time PCR expression Bcl-2,...
Intermittent application of parathyroid hormone (PTH) has well established anabolic effects on bone mass in rodents and humans. Although transcriptional mechanisms responsible for these are not fully understood, it is recognized that factor cAMP response element binding protein (CREB) mediates PTH signaling osteoblasts, there a communication between the PTH-CREB pathway BMP2 pathway, which important osteoblast differentiation formations. These findings, conjunction with putative elements...
BackgroundLactylation is a significant post-translational modification bridging the gap between cancer epigenetics and metabolic reprogramming. However, association lactylation prognosis, tumor microenvironment (TME), response to drug therapy in various cancers remains unclear.MethodsFirst, expression, prognostic value, genetic epigenetic alterations of genes were systematically explored pan-cancer manner. Lactylation scores derived for each using single-sample gene set enrichment analysis...
Arsenic trioxide (As 2 O 3 , ATO), a FDA approved drug for hematologic malignancies, was proved of efficient growth inhibition cancer cell in vitro or solid tumor vivo. However, its effect on vivo hampered by poor pharmacokinetics and dose-limited toxicity. In this study, polyacrylic acid capped pH-triggered mesoporous silica nanoparticles conducted to improve the enhance antitumor arsenic trioxide. The loaded with grafted (PAA-ATO-MSN) as pH-responsive biomaterial surface achieve release...
The aim of the study was to further explore pathogenesis idiopathic membranous nephropathy (IMN), gene-sequencing used analyze differentially expressed circRNAs in exosomes patients with IMN, which may lay foundation for research as a new class exosome-based IMN diagnosis biomarkers.Ten and ten normal controls were recruited experimental subjects our study. extracted from collected serum urine. Then, pure series enzymatic reactions. Afterwards, significantly chosen by method...
The structure of bacterial biofilms depends on environmental conditions, such as availability nutrients, during biofilm formation. In turn, variations in part reflect differences motility early Pseudomonas aeruginosa deprived nutrients remain dispersed a surface, whereas cells supplemented with additional cluster and form microcolonies. At the single-cell scale, how bacteria modify their to favour distinct life cycle outcomes remains poorly understood. High-throughput algorithms were used...
Abstract Skeletal muscle atrophy is one of the clinical symptoms myotonic dystrophy type 1 (DM1). A decline in skeletal regeneration an important contributor to atrophy. satellite cells (SSCs) drive regeneration. Increased autophagy can reduce proliferative capacity SSCs, which plays role early damaged DM1. Discovering new ways restore SSC proliferation may aid identification therapeutic targets for treatment In pathogenesis DM1, muscleblind-like (MBNL1) protein generally considered form...
Abstract Magnetotactic bacteria (MTB) are a group of phylogenetically and morphologically diverse prokaryotes that have the capability sensing Earth's magnetic field via nanocrystals iron minerals. These crystals enclosed within intracellular membranes or organelles known as magnetosomes enable function magnetotaxis. Although MTB were discovered over half century ago, study magnetosome biogenesis organization remains limited to few cultured strains. Here, we present an integrative genomic...
Aspergillus cristatus is a crucial edible fungus used in tea fermentation. In the industrial fermentation process, experiences low to high osmotic pressure environment. To explore law of material metabolism changes during changes, NaCl was here construct different environments. Liquid chromatography–mass spectrometry (LC–MS) combined with multivariate analysis performed analyze distribution and composition A. under salt concentrations. At same time, vitro antioxidant activity evaluated. The...
Abstract The color diversity of non-purple carrot taproots is mainly affected by carotenoid species and content. Carrot cytochrome P450 carotene β-ring hydroxylase (DcCYP97A3) may influence accumulation in carrots, however, the roles DcCYP97A3 remain unclear. Compared to orange ‘Kurodagosun, KRD’, yellow ‘Yellowstone, YST’ had greater relative transcript levels DcCYP97A3. was shown catalyze hydroxylation α-carotene create zeaxanthin when it expressed Escherichia coli accumulating α-...
<title>Abstract</title> Bacterial second messenger networks transmit environmental information through both amplitude and frequency modulation strategies. However, the mechanisms by which cells decode frequency-encoded signals remain poorly understood. By reconstructing cAMP system in Pseudomonas aeruginosa, we demonstrate that frequency-to-amplitude signal conversion (FAC) emerges three distinct filtering modules into gene expression patterns. Our mathematical framework predicts high-pass...
pH is an important environmental factor affecting the survival of fungi, and Aspergillus cristatus, which can grow reproduce over a wide range pH, suitable for studying their adaptation mechanism to stress. In this study, A. cristatus was cultured on plates different initial (pH 3.8-8.0), with results revealing distinct morphologies at 3.0-5.0, 6.0-7.0 8.0. Liquid chromatography-mass spectrometry (LC-MS) multivariate analysis subsequently were used analyze changes substance metabolism pH....
This study investigated resveratrol impact on oral squamous cell carcinoma (OSCC) via the NORAD/IGF2BP2/PDK1 pathway. CAL-27, SCC-25, and KB lines were used to evaluate proliferation, cycle arrest, protein expression. Key molecular markers assessed using Western blot, RNA interference, functional assays. Resveratrol inhibited growth of KB, SCC-25 cancer in a dose-dependent manner, with IC50 values 70, 145, 125 μg/mL, respectively (P < 0.01). In CAL-27 cells, 50 μg/mL induced G2/M arrest...
Abstract Signaling pathways for bone morphogenetic proteins (BMPs) are important in osteoblast differentiation. Although the precise function of type I BMP receptors mediating signaling differentiation and formation has been characterized previously, role II osteoblasts is to be well clarified. In this study, we investigated receptor (BMPR‐II) IIB activin (ActR‐IIB) BMP2‐induced While osteoblastic 2T3 cells expressed BMPR‐II ActR‐IIB, loss‐of‐function studies, using dominant negative siRNAs,...
Previous studies suggest that Akt signaling promotes tissue regeneration and decreased activities are found in aged tissues. However, this study finds the expression activation levels of mice skin increased with age. Additionally, Pten, p16, p21 p53 also elevated Immuno-fluorescence analysis showed phosphorylation epidermal cells (with NF-κB activation) were found. In vivo inhibition AKT activity result reduced activation. Our results increasing Akt/ is a crucial mediator aging, which can...