A5101829199- stochastic dynamics and bifurcation
- Nonlinear Dynamics and Pattern Formation
- Childhood Cancer Survivors' Quality of Life
- Cytomegalovirus and herpesvirus research
- Autophagy in Disease and Therapy
- Herpesvirus Infections and Treatments
- Fractional Differential Equations Solutions
- Probabilistic and Robust Engineering Design
- Chaos control and synchronization
- Palliative Care and End-of-Life Issues
- Sepsis Diagnosis and Treatment
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- Advanced Thermodynamics and Statistical Mechanics
- Ecosystem dynamics and resilience
- Hematopoietic Stem Cell Transplantation
- RNA modifications and cancer
- RNA Research and Splicing
- Hepatitis B Virus Studies
- Advanced biosensing and bioanalysis techniques
- Cholesterol and Lipid Metabolism
- Transcranial Magnetic Stimulation Studies
- Calcium signaling and nucleotide metabolism
- Lipid metabolism and biosynthesis
- Family Support in Illness
Third Affiliated Hospital of Harbin Medical University
2021-2025
Harbin Medical University
2021-2025
St. Jude Children's Research Hospital
2021-2025
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2013-2024
Zhejiang University
2013-2024
Sun Yat-sen University
2023-2024
First Affiliated Hospital Zhejiang University
2021-2024
Mudanjiang Medical University
2017-2024
The World Health Organization (WHO) designates early integration of palliative care as an ethical responsibility in the treatment children with serious illness. Although structural barriers may influence provision pediatric (PPC) for cancer resource-limited settings, underlying physician perceptions also impede PPC care. To investigate among physicians Latin America about cancer. This survey study used Assessing Doctors' Attitudes on Palliative Treatment (ADAPT) survey, which was developed...
Abstract Chemotherapeutics can induce immunogenic cell death (ICD) by triggering autophagy and mediate antitumor immunotherapy. However, using chemotherapeutics alone only cause mild cell‐protective be incapable of inducing sufficient ICD efficacy. The participation inducer is competent to enhance autophagy, so the level promoted effect immunotherapy highly increased. Herein, tailor‐made cascade amplification polymeric nanoparticles STF@AHPPE are constructed tumor Arginine (Arg),...
Cancer cells are characterized by malignant proliferation and aberrant metabolism thereby liable to the depletion of nutrients accumulation metabolic waste. To maintain cellular homeostasis, cancer prone upregulating canonical autophagy pathway. Here, we identified paroxetine hydrochloride (Paxil) as a late inhibitor investigated its killing effect on lung with xenograft mouse model in vivo. Upregulated LC3-II p62 expression indicated that Paxil inhibited autophagy. Acid-sensitive dyes...
Young adult survivors of childhood cancer exhibit rates frailty similar to adults several decades older without a history. Frailty has been associated with sleep disturbances in non-cancer populations, but the relationship not examined who are known elevated problems. Examine associations between and poor quality long-term cancer. This study utilized data from 9044 participants (> 5 years diagnosis, Mage = 40.8 [SD 9.5]) Childhood Cancer Survivor Study. Survivors' status, chronic health...
Abstract Skeletal muscle atrophy is one of the clinical symptoms myotonic dystrophy type 1 (DM1). A decline in skeletal regeneration an important contributor to atrophy. satellite cells (SSCs) drive regeneration. Increased autophagy can reduce proliferative capacity SSCs, which plays role early damaged DM1. Discovering new ways restore SSC proliferation may aid identification therapeutic targets for treatment In pathogenesis DM1, muscleblind-like (MBNL1) protein generally considered form...
Importance Early integration of pediatric palliative care (PPC) for children with cancer is critical the quality life both patient and family. To improve access to PPC in resource-limited settings, barriers early must be understood. Objectives evaluate ideal vs actual timing uncover identified by physicians Latin America. Design, Setting, Participants The Assessing Doctors’ Attitudes on Palliative Treatment (ADAPT) survey was distributed electronically from August 1, 2020, January 31, 2021,...
Abstract Background Sleep problems following childhood cancer treatment may persist into adulthood, exacerbating cancer-related late effects and putting survivors at risk for poor physical psychosocial functioning. This study examines sleep in long-term their siblings to identify factors disease correlates. Methods Childhood (≥5 years from diagnosis; n = 12 340; 51.5% female; mean [SD] age 39.4 [9.6] years) (n 2395; 57.1% 44.6 [10.5] participating the Cancer Survivor Study completed...
Background: Cerebral small vessel disease (SVD) is generally considered as a cause of stroke, disability, gait disturbances, vascular cognitive impairment, and dementia. The aim this study was to investigate whether the total SVD burden can be used predict functional outcome in patients with acute ischemic stroke. Methods: From April 2017 January 2018, consecutive stroke who underwent baseline MRI scan were evaluated. assessed using modified Rankin Scale (mRS) at 90 days defined i) excellent...
BackgroundViral infections are a major cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The effect herpesvirus in human cytomegalovirus (HCMV)-seropositive (IgG-positive/IgM-negative) HSCT recipients remains poorly understood. risk factors associated with Epstein–Barr virus (EBV), HCMV, herpes type 6 (HHV-6) HSCT, both alone combination, were investigated this study.MethodsPeripheral blood specimens collected from 44 examined for viral DNA using...
In this study, we investigate the stochastic resonance (SR) of a fractional linear oscillator subjected to multiplicative trichotomous noise and additive Gaussian driven by periodic signal. Using Shapiro-Loginov formula Laplace transformation technique, acquire exact expression first-order moment system's steady response. Meanwhile, discuss evolutions output amplitude with frequency signal parameters. We determine that bona fide SR, SR reverse-resonance exist in system. Specifically,...
Abstract Melanoma is the most lethal type of skin cancer. Despite breakthroughs in clinical treatment melanoma using tumor immunotherapy, many patients do not benefit from these immunotherapies because multiple immunosuppressive mechanisms. Therefore, there an urgent need to determine mechanisms tumor-immune system interactions and their molecular determinants improve cancer immunotherapy. In this study, combined analysis microarray data single-cell RNA sequencing revealed key between immune...
Both regulatory T cells and natural killer (NK) may play essential roles in the maintenance of pregnancy. In this study, we show that a significantly high percentage spontaneous embryo loss was observed both allogeneic syngeneic pregnant non-obese diabetic (NOD) mice. The mice further increased by administration anti-asialo ganglio-N-tetraosylceramide to deplete NK cells, but decreased adoptive transfer ITGA2(+)ISG20(+) (CD49b(+) CD25(+)) from normal No such trend NOD pattern CXCR4 (specific...
The sensitive characteristic to the initial value of chaos system sufficiently demonstrates superiority in weak signal parameters detection. Analyzing current chaos-based frequency detection method, a novel generalized Duffing equation is proposed detect frequency. By choosing suitable adjusting factor, when outside driving force equal that detected signal, oscillator great period state, which can obtain information signal. simulation results indicate this method rapidly convenient and shows...