A5077923290- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Pluripotent Stem Cells Research
- Atherosclerosis and Cardiovascular Diseases
- Periodontal Regeneration and Treatments
- Wnt/β-catenin signaling in development and cancer
- Pulmonary Hypertension Research and Treatments
- Knee injuries and reconstruction techniques
- Mesenchymal stem cell research
- Cardiovascular Function and Risk Factors
- Neuroscience and Neural Engineering
- Bone Metabolism and Diseases
- Connective Tissue Growth Factor Research
- Tendon Structure and Treatment
- Lipoproteins and Cardiovascular Health
- Cell Adhesion Molecules Research
- CRISPR and Genetic Engineering
- Collagen: Extraction and Characterization
- Silk-based biomaterials and applications
- Bone Tissue Engineering Materials
- Coronary Artery Anomalies
Cook Children's Medical Center
2020-2023
Houston Methodist
2018-2019
Rice University
2017-2018
Southwest Research Institute
2013
The University of Texas at San Antonio
2012
Through localized delivery of rapamycin via a biomimetic drug system, it is possible to reduce vascular inflammation and thus the progression disease.Use nanoparticles deliver vessel wall in an vivo model atherosclerosis after short dosing schedule.Biomimetic (leukosomes) were synthesized using membrane proteins purified from activated J774 macrophages. Rapamycin-loaded characterized dynamic light scattering found have diameter 108±2.3 nm, surface charge -15.4±14.4 mV, polydispersity index...
The use of nanomaterials as carriers for the delivery growth factors has been applied to a multitude applications in tissue engineering. However, issues toxicity, stability, and systemic effects these platforms have yet be fully understood, especially cardiovascular applications. Here, we proposed system composed poly(dl-lactide- co-glycolide) acid (PLGA) porous silica nanoparticles (pSi) deliver vascular endothelial factor (VEGF) platelet-derived (PDGF). tight spatiotemporal release two...
In a rat model of right free wall replacement, the transplantation an engineered multilayered myocardial patch fabricated from polycaprolactone membrane supporting chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling results in significantly higher ventricular ejection fraction compared to use commercially available pericardium patch.
Congenital heart defects are the most common birth defect. The limiting factor in tissue engineering repair strategies is an autologous source of functional cardiomyocytes. Amniotic fluid contains ideal cell for prenatal harvest and use correction congenital defects. This study aims to investigate potential amniotic fluid-derived stem cells (AFSC) undergo non-viral reprogramming into induced pluripotent (iPSC) followed by growth-factor-free differentiation AFSC from human second trimester...
Induced pluripotent stem cells (iPSCs) have been shown to differentiate functional cardiomyocytes (CM) with high efficiency through temporally controlled inhibition of the GSK3/Wnt signaling pathways. In this study, we investigated ability release small-molecule inhibitors drive cardiac differentiation iPSC without manual intervention. Porous silica particles were loaded GSK3 inhibitor CHIR99021 or Wnt IWP2, and containing IWP2 coated 5 wt% poly(lactic-co-glycolic acid) 50:50 delay by ∼72 h....
We have synthesized two types of nanoparticles (NPs) for controlled, localized delivery platelet-derived growth factor (PDGF). One type is based on a liposome formulation; another biodegradable polymer formulation. Liposome NPs high PDGF loading and efficiency. With similar small particle size distribution, PLGA-m-PEG-PDGF lower It allows controlled release over long period (e.g., up to 42 days). Based an electrochemical process which uses electrolysis water isoelectric focusing collagen, we...
Here we reported a novel electrochemical encapsulation method to encapsulate various nanomaterials and bimolecules into collagen. The process involves assembling of collagen along with Nano/bio materials using an isoelectric focusing mechanism. We have showed that wide range Nanomaterials such as carbon nanotubes, polymeric nanoparticles, magnetic calcium phosphate nanoparticles biomolecules can be encapsulated These collagen-based composite possess improved electric, mechanical,...