A5072394625- Single-cell and spatial transcriptomics
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Reproductive System and Pregnancy
- RNA Interference and Gene Delivery
- Pregnancy and Medication Impact
- MicroRNA in disease regulation
- Advanced biosensing and bioanalysis techniques
- Ferroptosis and cancer prognosis
- Pregnancy and preeclampsia studies
- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Gestational Trophoblastic Disease Studies
- Immune cells in cancer
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Retinoids in leukemia and cellular processes
- Advanced Nanomaterials in Catalysis
- Gut microbiota and health
- Ovarian cancer diagnosis and treatment
- Nanocluster Synthesis and Applications
- Cell Adhesion Molecules Research
- Circular RNAs in diseases
- Metal complexes synthesis and properties
- Cancer Cells and Metastasis
Women's Hospital, School of Medicine, Zhejiang University
2019-2025
Zhejiang University
2020-2024
Zhejiang University of Science and Technology
2022
Children's Hospital of Zhejiang University
2021
Hangzhou Xixi hospital
2016-2020
Women's Hospital
2020
Zhejiang Chinese Medical University
2016-2017
Changzhou No.2 People's Hospital
2014
Nanjing Medical University
2014
Abstract Purpose: The heterogeneity of high-grade serous ovarian cancer (HGSOC) is not well studied, which severely hinders clinical treatment HGSOC. Thus, it necessary to characterize the HGSOC within its tumor microenvironment (TME). Experimental Design: tumors 7 treatment-naïve patients with at early or late stages and five age-matched nonmalignant samples were analyzed by deep single-cell RNA sequencing (scRNA-seq). Results: A total 59,324 single cells obtained from tissues sequenced...
Ovarian cancer is a common malignancy in the female reproductive system with high mortality rate. The most important reason multidrug resistance (MDR) of chemotherapy. To reduce side effects, reverse and improve efficacy for treatment ovarian cancer, "core-shell" polymeric nanoparticle-mediated curcumin paclitaxel co-delivery platform was designed.Nuclear magnetic resonance confirmed successful grafting polyethylenimine (PEI) stearic acid (SA) (PEI-SA), which designed as mother core...
An innovative ferroptosis-inducing strategy integrating GSH exhaustion and ROS generation for cancer therapy.
Background and Purpose Short‐chain fatty acids (SCFAs) are metabolites from gut microbes involved in the host's inflammatory response immunity. The aim of this study was to investigate role SCFAs rheumatoid arthritis (RA) possible mechanisms. Experimental Approach Gut microbiota diversity mice analysed by 16S rDNA sequencing. levels were gas chromatography mass spectrometry. T B cells flow cytometry. Bone damage micro‐CT X‐ray. Histopathological status HE staining. Proteins tissues...
Abstract: During the past decade, "membrane lipid therapy", which involves regulation of structure and function tumor cell plasma membranes, has emerged as a new strategy for cancer treatment. Cholesterol is an important component membrane serves essential role in initiation progression. This review elucidates cholesterol tumorigenesis (including proliferation, invasion/metastasis, drug resistance, immunosuppressive microenvironment) elaborates on potential therapeutic targets treatment by...
Ligand/receptor-mediated targeted drug delivery has been widely recognized as a promising strategy for improving the clinical efficacy of nanomedicines but is attenuated by binding plasma protein on surface nanoparticles to form corona. Here, it shown that ultrasonic cavitation can be used unravel coronas liposomal through ultrasound (US)-induced reassembly. To demonstrate feasibility and effectiveness method, transcytosis-targeting-peptide-decorated reconfigurable liposomes (LPGLs) loaded...
The aim was to assess the expression levels of SLC7A11 and GPX4 in relation platinum resistance prognosis patients with epithelial ovarian cancer (EOC).A retrospective cohort study.Women's Hospital, Zhejiang University School Medicine, Hangzhou, China.We included 192 eligible from hospital between January 2002 December 2018.We retrospectively analysed medical records EOC. Surgical specimens EOC were stained for GPX4. Survival analysis performed using Kaplan-Meier Cox regression...
The poor capability of drugs to permeate through the blood–brain barrier (BBB) and further release inside glioma greatly limits curative effects chemotherapies. In this study, we prepared angiopep-2-conjugated liposome-silica hybrid nanovehicles for targeted delivery increased permeation arsenic trioxide (ATO) in glioma. Polyacrylic acid (PAA) was grafted on mesoporous silica nanoparticles (MSN) pH-sensitive supporting lipid membrane. "core–shell" (ANG-LP-PAA-MSN) were characterized with...
Arsenic trioxide (As 2 O 3 , ATO), a FDA approved drug for hematologic malignancies, was proved of efficient growth inhibition cancer cell in vitro or solid tumor vivo. However, its effect on vivo hampered by poor pharmacokinetics and dose-limited toxicity. In this study, polyacrylic acid capped pH-triggered mesoporous silica nanoparticles conducted to improve the enhance antitumor arsenic trioxide. The loaded with grafted (PAA-ATO-MSN) as pH-responsive biomaterial surface achieve release...
Endometriosis and Recurrent Implantation Failure (RIF) are both pivotal clinical issues within the realm of reproductive medicine, sharing significant overlap in their pathophysiological mechanisms. However, research exploring commonalities between these two conditions remains relatively scarce, reliable shared diagnostic biomarkers have yet to be identified. In this study, we integrated transcriptomic single-cell sequencing data from Gene Expression Omnibus (GEO) database identify genes...
Glioma is the most common primary malignant brain tumour and effect of chemotherapy hampered by low permeability across blood-brain-barrier (BBB). Borneol a time-honoured 'Guide' drug in traditional Chinese medicine has been proved to be capable promoting free drugs into efficiently, but there are still risks that drugs, especially anti-glioma may disassembled metabolised before penetrating BBB caused whole distribution. The purpose this paper was investigate whether borneol intervention...
The endometrial injury usually results in intrauterine adhesions (IUAs). However, there is no effective treatment to promote the regeneration of endometrium currently. decellularized amnion membrane (AM) a promising material human tissue repair and due its biocompatibility, biodegradability, as well preservation abundant bioactive components. Here, an innovative drug-delivering system based on amniotic extracellular matrix (HAECM) scaffolds were developed facilitate regeneration....
Cancer immunotherapy represents a medical breakthrough, but there are still many patients unable to benefit from it because of the low response rate. The immunosuppressive tumor microenvironment (TME) is main barrier immunotherapy. Alleviating intratumoral immunosuppression critical for improving immune therapeutic efficacy. This work developed an in situ vaccination strategy by using gold nanocage (AuNC)-based photothermal effect combination with adjuvant and PD-L1 suppressor. In specific,...