A5102004924- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Innovations in Medical Education
- Prenatal Screening and Diagnostics
- Interprofessional Education and Collaboration
- Parvovirus B19 Infection Studies
- Photodynamic Therapy Research Studies
- Catalytic C–H Functionalization Methods
- Barrier Structure and Function Studies
- Fetal and Pediatric Neurological Disorders
- Cancer Cells and Metastasis
- ATP Synthase and ATPases Research
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Synthesis and Catalytic Reactions
- Lung Cancer Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Clinical Reasoning and Diagnostic Skills
- MicroRNA in disease regulation
- Genomic variations and chromosomal abnormalities
- Cancer therapeutics and mechanisms
- Oxidative Organic Chemistry Reactions
- Empathy and Medical Education
- Medical Imaging and Pathology Studies
Shenzhen Maternity and Child Healthcare Hospital
2018-2025
Gannan Medical University
2020-2024
University of Chinese Academy of Sciences
2024
Zhejiang Cancer Hospital
2024
Chengdu University of Traditional Chinese Medicine
2022-2024
Shantou University
2024
Shantou University Medical College
2024
Qiqihar Medical University
2021-2023
Zhejiang University
2016-2021
Affiliated Hospital of Shandong Academy of Medical Sciences
2012-2021
Ovarian cancer is a common malignancy in the female reproductive system with high mortality rate. The most important reason multidrug resistance (MDR) of chemotherapy. To reduce side effects, reverse and improve efficacy for treatment ovarian cancer, "core-shell" polymeric nanoparticle-mediated curcumin paclitaxel co-delivery platform was designed.Nuclear magnetic resonance confirmed successful grafting polyethylenimine (PEI) stearic acid (SA) (PEI-SA), which designed as mother core...
nBu4NI-catalyzed C3-selective formylation of N–H and N-substituted indoles by using N-methylaniline as a formylating reagent was first successfully demonstrated.
One of the major obstacles in treatment breast cancer is stem cells (BCSC) which are resistant to standard chemotherapeutic drugs. It has been proven that microRNA-200c (miR-200c) can restore sensitivity microtubule-targeting drugs by reducing expression class III β-tubulin. In this study, combination therapy with miR-200c and paclitaxel (PTX) mediated lipid nanoparticles was investigated as an alternative strategy against BCSC.A cationic 1,2-dioleoyl-3-trimethylammonium-propane...
Responsive drug release in tumor mitochondria is a pre-requisite for mitochondria-targeted delivery systems to improve the efficacy of this promising therapeutic modality. To end, photothermal stimulation strategy mitochondria-responsive along with heat shock developed maximize antitumor effects minimal side effects. Methods: This relies on mitochondrial-targeted doxorubicin (DOX) through and lipophilic agent IR-780 iodide (IR780)-modified glycolipid conjugates (CSOSA), which can...
Myocardial infarction (MI) may cause heart failure and seriously harm human health. During the genesis of cardiac fibrosis after MI, proliferation migration fibroblasts contribute to secretion maintenance extracellular matrix (ECM) components. Many miRNAs have been highly implicated in processes MI. However, molecular mechanisms for how involve remain largely unexplored. Based on MI model miniature pigs, potential involved were identified by using small RNA sequencing. Using as a cellular...
The existence of blood–brain barrier (BBB) greatly hindered the penetration and accumulation chemotherapeutics into glioblastoma (GBM), accompany with poor therapeutic effects. growth GBM supervene impairment tight junctions (TJs); however, pathogenesis BBB breakdown in is essentially poorly understood. This study found that vascular endothelial factor (VEGF) secreted by cells plays an important role increasing permeability disrupting junction proteins claudin-5 thus gave doxorubicin...
Redox-responsive nanomaterials applied in drug delivery systems (DDS) have attracted an increasing attention pharmaceutical research as a carrier for antitumor therapy. However, there would be unwanted release from redox-responsive DDS with no selection at nontarget sites, leading to undesirable toxicities normal tissues and cells. Here, A54 peptide modified PEGylated reduction cleavable glucolipid conjugate (A54-PEG-CSO-ss-SA, abbreviated APCssA) was designed intracellular of doxorubicin...
Abstract Previous studies have implicated the attractive and promising role of miR‐590‐3p to restore cardiac function following myocardial infarction (MI). However, molecular mechanisms for how involves in fibrosis remain largely unexplored. Using human fibroblasts (HCFs) as cellular model, luciferase report assay, mutation, EdU assay transwell migration were applied investigate biological effects on proliferation, differentiation, collagen synthesis fibroblasts. We found that significantly...
Hydroxyurea (Green dots) efficiently promoted regional cerebral blood flow and increased BBB permeability. Thereby, more hypoxia-sensitive liposomes NIPP/ER@HL-D were transported to lesions entered brain exert anti-stroke efficacy.
The phenotype of SCA patients are diversities, make prenatal counseling and parental decision-making following the diagnosis more complicated challenging. NIPT has higher sensitivity specificity in screening trisomy 21 syndrome, but effectiveness detecting is still controversial. This study a large-scale retrospective cohort positive screened from unselected singleton pregnancies by non-invasive testing (NIPT) single center tertiary hospital. Clinical information, indications, diagnostic...
Objective To describe the characterization of a novel deletion causing α-thalassemia. Methods The proband was 4-year-old boy who presented with abnormal hematological parameters identified during routine blood investigation conducted for cold. Three common α-globin gene deletions, three mutations, and 17 mutations in β-globin were detected using PCR-flow fluorescence hybridization. Next-generation sequencing (NGS) CNVplex technologies employed to identify potential rare pathogenic mutation...
A one-pot dual functionalization of indoles has been developed. The simultaneous C3-formylation and N-aminomethylation can be achieved using readily available potassium iodide as a catalyst tert-butyl peroxybenzoate co-oxidant.
The critical process and step in achieving effective antitumor therapies is facilitating endosomal escape, which can enhance the intracellular target delivery of therapeutics. However, normally adopted approaches tend to result colloidal instability as a inevitable interactions between resulting positively charged surfaces micelles proteins vivo. Herein, negatively surface shielded polymeric micelles, consisting polymethylacrylamide derivatives hydrophilic chitosan (Mw = 18.8 kDa) linked by...
Biomimetic nano-platforms have attracted extensive attention due to their good biocompatibility, low immunogenicity, and homologous targeting lesions. In this study, glioma cell membranes are used encapsulate indocyanine green (ICG) loaded nanoparticles (SLNP/ICG), termed as SLNP/ICG@M for targeted photodynamic therapy (PDT) against glioma. Cell membrane modification significantly enhances cellular uptake of in cells vitro tumor distribution vivo. Furthermore, can stimulate generate...
Abstract Background Noninvasive prenatal testing (NIPT) is commonly used to screen for fetal genetic abnormalities. However, the ability of NIPT detect copy number variations (CNVs) has not been reported. Accordingly, in this study, we analyzed efficiency detection autosomal CNVs. Methods Patients who were positive CNVs by and underwent diagnostic studies karyotype analysis chromosomal microarray (CMA) evaluated. Samples divided into groups according age, vitro fertilization, fetal‐free DNA...
Stemness and metastasis are the two main challenges in cancer therapy related to disease relapse post-treatment. They both have a strong correlation with chemoresistance poor prognosis, ultimately leading treatment failure. It has been reported that chemotherapy can induce stemness many types, especially chemotherapeutic agent doxorubicin (DOX) breast cancer. A combination is an efficient elegant approach through simultaneous delivery of or more drugs system for its synergistic effect, which...
Triple-negative breast cancer (TNBC) is an aggressive and highly lethal disease. The lack of targeted therapies poor patient outcome have fostered efforts to discover new molecular targets treat patients with TNBC. Here, we showed that baculoviral IAP repeat containing 6 (BIRC6) overexpressed positively correlated epidermal growth factor (EGF) receptor (EGFR) in TNBC cells tissues BIRC6 overexpression associated survival. Mechanistic studies revealed stability increased by EGF-JNK signaling,...