Jian Lü

ORCID: 0000-0003-2010-7190
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About
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Research Areas
  • Animal Nutrition and Physiology
  • Genetic and phenotypic traits in livestock
  • Livestock and Poultry Management
  • Prenatal Screening and Diagnostics
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Genetic Mapping and Diversity in Plants and Animals
  • Animal Virus Infections Studies
  • Moringa oleifera research and applications
  • Virus-based gene therapy research
  • Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Cancer-related molecular mechanisms research
  • Silkworms and Sericulture Research
  • Muscle Physiology and Disorders
  • Genomic variations and chromosomal abnormalities
  • Trace Elements in Health
  • Immune Response and Inflammation
  • Selenium in Biological Systems
  • Animal Behavior and Welfare Studies
  • Adipose Tissue and Metabolism
  • Retinal Development and Disorders
  • Congenital Anomalies and Fetal Surgery
  • Rabbits: Nutrition, Reproduction, Health
  • Neuroscience and Neuropharmacology Research
  • Exercise and Physiological Responses
  • NF-κB Signaling Pathways

Poultry Research Institute
2015-2024

National Animal Husbandry Service
2024

Guangdong Province Women and Children Hospital
2011-2024

University of Rome Tor Vergata
2023-2024

Chinese Academy of Agricultural Sciences
2014-2023

Southeast University
2022

Ministry of Education of the People's Republic of China
2022

Nanjing Agricultural University
2020-2021

East China Normal University
2009-2020

Zunyi Medical University
2017-2020

Growth and meat production traits are significant economic in sheep. The aim of the study is to identify candidate genes affecting growth at genome level with high throughput single nucleotide polymorphisms (SNP) genotyping technologies.

10.1371/journal.pone.0066569 article EN cc-by PLoS ONE 2013-06-25

Abstract Background Chinese indigenous sheep are valuable resources with unique features and characteristics. They distributed across regions different climates in mainland China; however, few reports have analyzed the environmental adaptability of based on their genome. We examined variants signatures selection involved adaptation to extreme humidity, altitude, temperature conditions 173 genomes from 41 phenotypically geographically representative breeds characterize genetic basis...

10.1186/s12711-024-00880-z article EN cc-by Genetics Selection Evolution 2024-04-02

Abstract Reactive changes in astrocytes and Müller cells the retina of adult rats subjected to hypoxia were investigated. Along with this, integrity blood–retinal barrier (BRB) was assessed using fluorescent electron‐dense tracers. In hypoxic rats, mRNA protein expression glial fibrillary acidic (GFAP) aquaporin‐4 (AQ4) significantly increased. AQ4 immunoreactive identified as by double immunofluorescence labelling. Another alteration marked reduction melatonin content compared controls....

10.1002/path.2195 article EN The Journal of Pathology 2007-06-21

An experiment was conducted to evaluate the effect of stocking density on growth performance, carcass yield, and immune status a local chicken breed. In total, 840 one-day-old male Suqin yellow chickens were placed into 4-m(2) cages in groups 50 (low), 70 (medium), or 90 (high) birds. Each treatment represented by 4 replicates (cages). The measured 2.84 × 1.42 m; half area cage (2 m(2)) used from 1 28 d whole 29 42 d. Stocking densities 25, 35, 45 birds/m(2) 12.5, 17.5, 22.5 (low, medium,...

10.3382/ps.2011-01597 article EN cc-by-nc-nd Poultry Science 2012-02-14

As a major economic trait in chickens, egg weight (EW) receives widespread interests breeding, production and consumption. However, limited information is available for underlying genetic architecture of longitudinal trend EW. Herein, we measured EWs at nine time points from onset laying to 60 week age, conducted comprehensive genome-wide association studies (GWAS) 1,534 F2 hens derived reciprocal crosses between White Leghorn Dongxiang chickens. Egg weights all ages except the first (FEW)...

10.1186/s12864-015-1945-y article EN cc-by BMC Genomics 2015-10-05

Organic selenium (Se) supplementation from Se-enriched yeast (SY) has been advocated and approved for use in animal feeds by some nutritionists researchers rather than inorganic Se sodium selenite. However, there is little available safety data of SY laying hens. A subchronic study was conducted to determine if high-dose affects the total 768, 30-wk-old, Hy-Line Brown hens were randomly assigned 1 4 groups (192 per group) with 6 replicates 32 birds each. After a 2-wk acclimation period, fed...

10.3382/ps/pey597 article EN cc-by-nc-nd Poultry Science 2019-02-01

Abstract Monocyte chemoattractant protein‐1 (MCP‐1), a member of β‐chemokine subfamily, regulates the migration microglia, monocytes, and lymphocytes to inflammatory site in central nervous system. We sought determine if amoeboid microglial cells (AMC) produce MCP‐1 that may be linked AMC corpus callosum periventricular white matter hypoxic neonatal rats. A striking feature 1‐day‐old rats subjected hypoxia was marked increase cell numbers immunoexpression its receptor (CCR 2 ). By BrdU...

10.1002/glia.20790 article EN Glia 2008-10-22

Abstract Microglial cells constitutively express Notch‐1 and nuclear factor‐κB/p65 (NF‐κB/p65), both pathways modulate production of inflammatory mediators. This study sought to determine whether a functional relationship exists between them and, if so, investigate they synergistically regulate common microglial cell functions. By immunofluorescence labeling, real‐time polymerase chain reaction (RT‐PCR), flow cytometry, Western blot, BV‐2 exhibited NF‐κB/p65 expression, which was...

10.1002/jnr.22429 article EN Journal of Neuroscience Research 2010-05-27

Protein feed sources are becoming more and limited worldwide. Soybean meal, as the primary most reliable protein source, is increasingly expensive; therefore, there a need to look for economic alternative sources. This trial was conducted evaluate effects of graded replacement soybean meal by sunflower seed (SSM) on performance, egg quality, fatty acid composition, cholesterol content in Rugao laying hens (a local breed). One hundred sixty 28-wk-old were randomly assigned 4 groups 40 birds....

10.3382/japr.2011-00437 article EN cc-by-nc-nd The Journal of Applied Poultry Research 2012-05-21

An experiment was conducted to evaluate the effect of free-range days on growth performance, carcass yield, meat quality, and lymphoid organ index a local chicken breed. In total, 1,000 one-day-old male Suqin yellow chickens were raised for 21 d. On d 21, 720 birds with similar BW (536 ± 36 g) selected randomly assigned treatment at 28, 35, 42 age (assigned 14, 7, 0 d, respectively). Each represented by 5 replicates (pens) containing (180 per treatment). All in indoor floor pens measuring...

10.3382/ps.2013-03470 article EN cc-by-nc-nd Poultry Science 2014-06-16

The aim of this study was to compare the dynamic changes egg selenium (Se) deposition and efficiency evaluate efficacy selenium-enriched yeast (SY) in laying hens over 84 d feeding period after SY supplementation. A total one thousand hundred fifty-two 30-wk-old, Hy-Line Brown were randomly assigned 1 6 groups (192 per group) with replicates 32 birds each, fed a basal diet (without Se supplementation), 0.3 mg/kg from sodium selenite (SS) or diets 0.1, 0.2, 0.3, 0.4 SY, respectively. results...

10.1016/j.psj.2020.07.041 article EN cc-by-nc-nd Poultry Science 2020-08-12

The objective of the current study was to investigate influence including whole corn (WC) in goose diets on performance, digestive tract development, and nutrient retention. A total 112 Yangzhou geese, 7 d old with similar BW, were distributed into 8 pens 14 birds/pen (7 male, female). Each treatment represented by 4 replicates. Geese fed corn-soybean-based containing 640 g (8-28 d) 615 (29-70 corn/kg diet from 70 age, 2 particle sizes grains used: ground (GC) WC. During period 49 d, daily...

10.3382/ps.2010-01054 article EN cc-by-nc-nd Poultry Science 2011-02-16

Because it serves as the cytoplasm of oocyte and provides a large amount reserves, egg yolk has biological significance for developing embryos. The ovary its hierarchy follicles are main reproductive organs responsible deposition in chickens. However, genetic architecture underlying ovarian follicle weights remains elusive. Here, we measured weight (YW) at 11 age points from onset laying to 72 weeks (FW) (OW) 73 part comprehensive genome-wide association study (GWAS) 1,534 F2 hens derived...

10.1371/journal.pone.0137145 article EN cc-by PLoS ONE 2015-09-02

Background The prevalence of carbapenem-resistant Acinetobacter baumannii in hospitals has been increasing worldwide. This study aims to investigate the carbapenemase genes and clonal relatedness among A. clinical isolates a Chinese hospital. Methods Carbapenemase upstream locations insertion sequences were detected by polymerase chain reaction (PCR), was determined pulsed-field gel electrophoresis (PFGE) multilocus sequence typing. Results A total 231 nonduplicate gene-harboring recovered...

10.1371/journal.pone.0137174 article EN cc-by PLoS ONE 2015-09-04

Abstract Background Noninvasive prenatal testing (NIPT) is commonly used to screen for fetal genetic abnormalities. However, the ability of NIPT detect copy number variations (CNVs) has not been reported. Accordingly, in this study, we analyzed efficiency detection autosomal CNVs. Methods Patients who were positive CNVs by and underwent diagnostic studies karyotype analysis chromosomal microarray (CMA) evaluated. Samples divided into groups according age, vitro fertilization, fetal‐free DNA...

10.1002/mgg3.1339 article EN cc-by Molecular Genetics & Genomic Medicine 2020-06-15

The aim of this study was to assess the effects energy-restricted feeding during growing phase on productive performance Hyline Brown laying hens aged 6 72 wk. A total 720 six-week-old layer chicks were allocated equally 3 groups with replicates 40 pullets each, and fed 1 diets that nutritionally similar except for apparent metabolizable energy corrected nitrogen (AMEn) content. At age 17 wk, in control group given diet 2,850 kcal/kg AMEn, ad libitum. levels AMEn experimental 90% (2,565...

10.1016/j.psj.2023.102942 article EN cc-by-nc-nd Poultry Science 2023-07-19

The comb, as a secondary sexual character, is an important trait in chicken. Indicators of comb length (CL), height (CH), and weight (CW) are often selected production. DNA-based marker-assisted selection could help chicken breeders to accelerate genetic improvement for or related economic characters by early selection. Although number quantitative loci (QTL) candidate genes have been identified with advances molecular genetics, underlying traits limited. aim the study was use genome-wide...

10.1371/journal.pone.0159081 article EN cc-by PLoS ONE 2016-07-18

The aim of this study was to compare the dynamic change egg selenium (Se) deposition after sodium selenite (SS) or selenium-enriched yeast (SY) supplementation for 1, 3, 5, 7, 14, 21, 28, 56, and 84 d. A total 576 32-wk-old Hy-Line Brown laying hens were randomly assigned 3 groups (192 per group) with 6 replicates, fed a basal diet (without Se supplementation) diets 0.3 mg/kg from SS SY, respectively. results showed that concentrations in eggs SY-supplemented significantly higher (P < 0.001)...

10.3382/ps/pey161 article EN cc-by-nc-nd Poultry Science 2018-05-19
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