A5101482572- SARS-CoV-2 and COVID-19 Research
- Oral microbiology and periodontitis research
- Retinal Development and Disorders
- Cell Adhesion Molecules Research
- Salivary Gland Disorders and Functions
- Cellular transport and secretion
- Rough Sets and Fuzzy Logic
- Immune cells in cancer
- Dental Health and Care Utilization
- Cardiac Fibrosis and Remodeling
- Retinal Diseases and Treatments
- Spectroscopy and Chemometric Analyses
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Retinal and Macular Surgery
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Data Mining Algorithms and Applications
- Craniofacial Disorders and Treatments
- Calcium signaling and nucleotide metabolism
- Grouting, Rheology, and Soil Mechanics
- Cleft Lip and Palate Research
- Higher Education and Teaching Methods
- Caveolin-1 and cellular processes
- Wnt/β-catenin signaling in development and cancer
- Cervical and Thoracic Myelopathy
First Affiliated Hospital of Kunming Medical University
2023-2024
Kunming Medical University
2023-2024
Guangdong Laboratory Animals Monitoring Institute
2017-2024
Chaohu Hospital of Anhui Medical University
2010-2023
Southern Medical University
2017-2022
Zhejiang Chinese Medical University
2022
Monash University Malaysia
2020
Bridge University
2020
Guangzhou Medical University
2020
Huazhong University of Science and Technology
2017-2018
Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that mainly transfers from human to via and gastrointestinal routes. The S-glycoprotein in the virus key factor for entry of SARS-CoV-2 into cell, which contains two functional domains: S1 an angiotensin-converting enzyme (ACE2) receptor binding domain, S2 necessary fusion cell membranes. Moreover, it has been reported ACE2 likely be SARS-CoV-2. In addition, mRNA level...
Myocardial infarction (MI) may cause heart failure and seriously harm human health. During the genesis of cardiac fibrosis after MI, proliferation migration fibroblasts contribute to secretion maintenance extracellular matrix (ECM) components. Many miRNAs have been highly implicated in processes MI. However, molecular mechanisms for how involve remain largely unexplored. Based on MI model miniature pigs, potential involved were identified by using small RNA sequencing. Using as a cellular...
Abstract Previous studies have implicated the attractive and promising role of miR‐590‐3p to restore cardiac function following myocardial infarction (MI). However, molecular mechanisms for how involves in fibrosis remain largely unexplored. Using human fibroblasts (HCFs) as cellular model, luciferase report assay, mutation, EdU assay transwell migration were applied investigate biological effects on proliferation, differentiation, collagen synthesis fibroblasts. We found that significantly...
Introduction Lyme arthritis (LA) is a chronic inflammatory joint disease caused by Borrelia burgdorferi infection, with approximately 10-20% of patients developing antibiotic resistance. Macrophages in the synovial microenvironment play crucial role progression, but their precise regulatory mechanisms remain unclear. Methods We analyzed scRNA-seq data (GSE233850) from LA mouse tissue and integrated transcriptomic models GSE125503 dataset. Cell clustering, differential gene analysis, GO KEGG...
Studies were performed to examine the mutational pattern of K-ras exons 1 and 2 p53 5-8 in lung cancer tissues from 27 Chinese patients (10 smokers, 17 non-smokers) using single-stranded conformational polymorphism DNA sequencing. mutations found 13/27 tumors (48%); all clustered exon distributed between codons 9 32. The frequency number with smokers non-smokers not different, except that a high G --> A transitions (11/11) was non-smokers. Among cell types, 7/13 (54%) squamous carcinoma (SC)...
Abstract Background Leading to a sustained epidemic spread with >2,000,000 confirmed human infections, including >100,000 deaths, COVID-19 was caused by SARS-CoV-2 and resulted in acute respiratory distress syndrome (ARDS) sepsis, which brought more challenges the patient’s treatment. The S-glycoprotein, recognized as key factor for entry of into cell, contains two functional domains: an ACE2 receptor binding domain second necessary fusion coronavirus cell membranes. FURIN activity,...
Abstracts The COVID-19 pandemic, caused by the SARS-CoV-2 virus and its variants, has posed unprecedented challenges worldwide. Existing vaccines have limited effectiveness against variants. Therefore, novel to match mutated viral lineages providing long-term protective immunity are urgently needed. We designed a recombinant adeno-associated 5 (rAAV5)-based vaccine (rAAV-COVID-19) using spike protein receptor binding domain (RBD-plus) sequence with both single-stranded (ssAAV5)...
Objective To evaluate the feasibility and efficacy of intraoperative ultrasonography in laparoscopic partial nephrectomy (LPN) for intrarenal tumors. Patients methods All patients who underwent LPN renal tumors our institution from January 2010 to October 2016 were assessed retrospectively. divided into two groups, first with totally (TIT group), defined as a solid mass no exophytic element on both preoperative evaluations, second (control group). General information perioperative data...
Best vitelliform macular dystrophy (BVMD) is a hereditary retinal disease characterized by the bilateral accumulation of large egg yolk‑like lesions in sub‑retinal and pigment epithelium spaces. Macular degeneration BVMD can begin childhood or adulthood. The variation age onset not clearly understood. present study clinical characteristics two Chinese patients with either juvenile‑onset adult‑onset investigated underlying genetic variations. A 16‑year‑old male (Patient 1) was diagnosed...
The aim of the present study was to identify mutations in fibroblast growth factor receptor 2 (FGFR2) gene patients with Crouzon syndrome and characterize associated clinical features. A total two Chinese diagnosed underwent complete examinations, including best‑corrected visual acuity, slit‑lamp, examination, fundus optical coherence tomography computed skull. Genomic DNA extracted from peripheral blood samples collected patients, as well their family members 200 unrelated control subjects...
The aim of the present study was to investigate clinical characteristics and underlying genetic causes Best vitelliform macular dystrophy (BVMD) in a sporadic case Chinese patient. A 10‑year‑old boy diagnosed with BVMD; complete ophthalmic examinations were performed, including best‑corrected visual acuity, intraocular pressure, slit‑lamp examination, fundus photograph, optical coherence tomography fluorescein angiography imaging. Genomic DNA extracted from leukocytes peripheral blood...
Congenital macular coloboma is characterized by defined punched out atrophic lesions of the macula. The present study aimed to investigate genetic alterations one Chinese sporadic patient with bilateral large coloboma. Complete ophthalmic examinations, including best‑corrected visual acuity, slit‑lamp examination, fundus photograph and fluorescein angiography imaging, Pentacam, optical coherence tomography were performed on patient. Genomic DNA was extracted from leukocytes in a peripheral...
Familial exudative vitreoretinopathy (FEVR) is a rare hereditary retinal disorder characterized by the premature arrest of vascularization in peripheral retina. The aim present study was to characterize clinical presentations Chinese family affected bilateral severe FEVR, and identify underlying genetic variations. One that presented with FEVR recruited for this study. Comprehensive ophthalmic examinations, including best‑corrected visual acuity, slit‑lamp examination, fundus photography,...
Congenital aniridia is a rare genetic disorder characterized by variable degree of hypoplasia or absence iris. It frequently associated with keratopathy, cataract, juvenile‑onset glaucoma and foveal optic nerve hypoplasia. Mutations in the Paired Box 6 (PAX6) gene on chromosome 11p13 have been demonstrated to cause aniridia. The aim present study was investigate variations PAX6 two sporadic patients from southern China classic congenital cataract. Complete ophthalmic physical examinations...
Stickler syndrome is a group of inherited connective tissue disorders characterized by distinctive facial and ocular abnormalities, hearing loss early‑onset arthritis. The aim the present study was to investigate genetic changes in two Chinese patients with syndrome, manifested as bilateral retinal detachment peripheral degeneration. Complete ophthalmic examinations, including best‑corrected visual acuity, slit‑lamp examination fundus examination, were performed. Genomic DNA extracted from...
Abstract Facial soft tissue injuries, often resulting in scarring, pose a challenge reconstructive and aesthetic surgery due to the need for functional restoration. This study evaluates efficacy of recombinant human growth factors (rhGFs) scar remodelling such injuries. A retrospective evaluation was conducted from January 2020 2023, involving 100 patients with facial Participants were divided equally into control group, receiving standard cosmetic surgical repair, an observation treated...
Monkeys are an appropriate model for periodontal research owing to their similar dental anatomy and physiology unlike humans. Extensive literature exists on pathological periodontitis in monkeys humans, although concerns regarding whether healthy middle-aged humans display the same oral microbial status remains unclear.