A5041315129- Advanced Breast Cancer Therapies
- Cancer-related Molecular Pathways
- Kidney Stones and Urolithiasis Treatments
- Cancer Treatment and Pharmacology
- PI3K/AKT/mTOR signaling in cancer
- Pelvic floor disorders treatments
- Bladder and Urothelial Cancer Treatments
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Urinary Bladder and Prostate Research
- Lung Cancer Treatments and Mutations
- Anorectal Disease Treatments and Outcomes
- Pelvic and Acetabular Injuries
- Magnesium in Health and Disease
- Biomedical Research and Pathophysiology
- Surgical Sutures and Adhesives
- Synthesis and biological activity
- Circular RNAs in diseases
- Urinary and Genital Oncology Studies
- Therapeutic Uses of Natural Elements
- Vitamin D Research Studies
- Cancer therapeutics and mechanisms
- Nephrotoxicity and Medicinal Plants
- Dermatologic Treatments and Research
- RNA modifications and cancer
Kunming Medical University
2012-2025
First Affiliated Hospital of Kunming Medical University
2020-2025
Chinese University of Hong Kong
2024
Shandong Academy of Pharmaceutical Sciences
2024
Zhengzhou University
2024
This study aims to investigate the role of hypercalciuria and pyroptosis in formation calcium oxalate kidney stones. Bioinformatics analysis was performed compare correlation scores cell adhesion between Randall's plaques normal tissues from stone patients. For vitro experiments, we investigated effects high concentrations Ca2+ on levels renal tubular epithelial cells examined crystal aggregation environment by knockdown overexpression key gene, GSDMD, verified concentration levels, injury,...
Bladder cancer (BC) is the fourth-commones and sixth-leading cause of cancer-related death among men. However, a lack reliable biomarkers remains problem forprognosis treatment BC. lncRNAs have been shown to play important roles in various cancers, emerged as promising for prognosis treatment. In this study, using univariate multivariate Cox regression analysis, we examined differential expression profiles 1,651 TCGA BLCA cohort created prognostic gene signature composed six (for SNHG12,...
Cyclin-dependent kinases (CDKs) are hyperactive in many cancers and have served as cancer therapeutic targets for decades. Palbociclib (Palb) is the first approved CDK4/6 inhibitor to treat hormone receptor (HR)-positive, HER2-negative advanced breast cancer. Acquired drug resistance one obstacle of Palb be utilized other CDK2 compensation loss causes that cells resistant Palb. Hence, targeting multiple CDKs could a novel strategy prevent expand application In this study, we initially...
The phosphatidylinositol-3-kinase (PI3K)/AKT signaling pathway plays a pivotal role in many cellular processes, including the proliferation, survival and differentiation of lung cancer cells. Thus, PI3K is promising therapeutic target for treatment. In this study, we applied free open-source protein-ligand docking software, screened 3167 FDA-approved small molecules, identified putative PI3Kα inhibitors. Among them, econazole nitrate, an antifungal agent, exhibited highest activity...
Background:The phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway is hyperactivated in lung cancer and regulates a broad range of cellular processes, including proliferation, survival, angiogenesis, metastasis.Thus PI3K considered promising target for therapy.To date, inhibitors have not been approved cancer.Recent studies showed that the antipsychotic agent flupentixol induced apoptosis cell, however anti-tumor mechanism remains unclear.Methods: (1) The idock software simulated...
To analyze the role of axial positions uterus and vagina in providing pelvic floor support, encourage evaluations function, improve understanding pathogenesis organ prolapse.The lengths angles upper, middle, lower axes vagina, uterine body, cervix 81 women with prolapse (prolapse group) 57 without (non-prolapse were measured compared using magnetic resonance images. The inclination correction system (PICS) line was also between groups. coordinate parameters anatomical points measured, their...
Abstract Background Cyclin-dependent kinases 2/4/6 (CDK2/4/6) play critical roles in cell cycle progression, and their deregulations are hallmarks of hepatocellular carcinoma (HCC). Methods We used the combination computational experimental approaches to discover a CDK2/4/6 triple-inhibitor from FDA approved small-molecule drugs for treatment HCC. Results identified vanoxerine dihydrochloride as new inhibitor, strong cytotoxicdrugin human HCC QGY7703 Huh7 cells (IC50: 3.79 μM QGY7703and 4.04...
Bladder carcinoma ( BC ) is the ninth most common cause of cancer worldwide. Surgical resection and conventional chemotherapy radiotherapy will ultimately fail due to tumor recurrence resistance. Thus, development novel treatment urgently needed. Fibroblast growth factor receptor 3 FGFR 3) an important well‐established target for treatment. In this study, we utilized free open‐source protein–ligand docking software idock prospectively identify potential inhibitors from 3,167 worldwide...
Background: Hepatocellular carcinoma (HCC) is a lethal malignancy lacking effective treatment. The Cyclin-dependent kinases 4/6 (CDK4/6) and PI3K/AKT signal pathways play pivotal roles in carcinogenesis are promising therapeutic targets for HCC. Here we identified new CDK4/6 multi-kinase inhibitor the treatment of Methods: Using repurposing ensemble docking methodology, screened library worldwide approved drugs to identify candidate inhibitors. By MTT, apoptosis, flow cytometry analysis,...
The aim of this study was to provide a potential surgical efficacy assessment in the treatment pelvic organ prolapse (POP).A retrospective cohort performed on magnetic resonance imaging (MRI) data 16 non-prolapsed (control group) and 30 preoperative postoperative POP (case women from 2019 2021 at First Affiliated Hospital Kunming Medical University. MRI diagnoses measures relevant anatomical points rest were used analyze healthy control before after surgery.The middle vaginal-PICS line angle...
Abstract Background Accumulating evidence has revealed the critical role of long non-coding RNAs (lncRNAs) in cellular processes during tumor progression. As documented cancer-related literatures, LINC00992 expression is associated with cancer progression, whereas its function tumors including prostate not been characterized yet. Methods Data from GEPIA database suggested tissues. The levels were monitored via qRT-PCR. Western blot evaluated proteins. proliferation, apoptosis and migration...
Abstract Facial soft tissue injuries, often resulting in scarring, pose a challenge reconstructive and aesthetic surgery due to the need for functional restoration. This study evaluates efficacy of recombinant human growth factors (rhGFs) scar remodelling such injuries. A retrospective evaluation was conducted from January 2020 2023, involving 100 patients with facial Participants were divided equally into control group, receiving standard cosmetic surgical repair, an observation treated...
Background: Hepatocellular carcinoma (HCC) is a lethal malignancy lacking effective treatment. The Cyclin-dependent kinases 4/6 (CDK4/6) and PI3K/AKT signal pathways play pivotal roles in carcinogenesis are promising therapeutic targets for HCC. Here we identified new CDK4/6 multi-kinase inhibitor the treatment of Methods: Using repurposing ensemble docking methodology, screened library worldwide approved drugs to identify candidate inhibitors. By MTT, apoptosis, flow cytometry analysis,...
Objectives To evaluate the clinical efficacy of percutaneous nephrolithotomy(PCNL)in combination with pneumatic and ultrasonic lithotripsy under guidance B-mode ultrasound in treatment complex renal calculi.Methods We retrospectively analyzed records 356 patients calculi who underwent PCNL combined at our department from October 2008 to March 2012.Results A single tract was used 319 patients,while two tracts were created 37 patients.One-step procedure remove stones achieved 292 a second...
Abstract: Aim/Background: The current study was conducted to examine the influence of atorvastatin in experimentally induced prostatic intraepithelial neoplasia rats. TRPM7 is a potential therapeutic target for treatment prostate cancer. Materials and Methods: In this study, we investigated effects (25 50 mg/kg/BW p.o.) on cell proliferation by sequential regimen testosterone plus single administration 7,12-Dimethylbenz(a) anthracene. Results: Results present revealed that different pattern...
Abstract Background Cyclin-dependent kinases 2/4/6 (CDK2/4/6) play critical roles in cell cycle progression, and their deregulations are hallmarks of hepatocellular carcinoma (HCC).Methods Here we combined computational experimental approaches to discover a CDK2/4/6 triple-inhibitor from FDA approved small-molecule drugs for the treatment HCC.Results Based on molecular docking results, vanoxerine dihydrochloride was found exhibit strongest cytotoxic effect human HCC QGY7703 Huh7 cells (IC50:...
Abstract Background: Cyclin-dependent kinases 2/4/6 (CDK2/4/6) play critical roles in cell cycle progression, and their deregulations are hallmarks of hepatocellular carcinoma (HCC). Methods: We used the combination computational experimental approaches to discover a CDK2/4/6 triple-inhibitor from FDA approved small-molecule drugs for treatment HCC. Results: identified vanoxerine dihydrochloride as new inhibitor, strong cytotoxic drug human HCC QGY7703 Huh7 cells (IC50: 3.79 μM 4.04 cells)....
Abstract The epidermal growth factor receptor (EGFR) is a promising therapeutic target in bladder cancer (BC). Thus, the development of novel EGFR inhibitor urgently needed. We computationally screened 3,167 worldwide approved small molecule drugs for potential wild‐type inhibitors. antibiotic and antiprotozoal agent dibromopropamidine dihydrochloride exhibited highest cytotoxic activity dose‐ time‐dependent manner, with IC 50 similar to that reported FDA inhibitors, gefitinib higher than...
Background and Objectives: pseudo urgency syndrome among patients with mixed incontinence (MUI) causes the corresponding treatment strategies is explored. Materials Methods: A total of 40 MUI are treated transobturator tape (TOT) and/or solifenacin succinate. Further, 30 simple stress urinary (SUI) that were from period December 2018 to August 2020 retrospectively analyzed; then, their clinical characteristics therapeutic effects summarized analyzed. Results: The effective rates SUI symptoms...