A5021952657- Cancer therapeutics and mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- Cancer, Stress, Anesthesia, and Immune Response
- Lung Cancer Research Studies
- Anesthesia and Neurotoxicity Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammasome and immune disorders
- Cancer Research and Treatments
- interferon and immune responses
- Intensive Care Unit Cognitive Disorders
- RNA modifications and cancer
- Sirtuins and Resveratrol in Medicine
- Circular RNAs in diseases
- Transplantation: Methods and Outcomes
- Bioactive Compounds and Antitumor Agents
- Viral-associated cancers and disorders
- Cancer-related gene regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Nitric Oxide and Endothelin Effects
- Biofield Effects and Biophysics
- S100 Proteins and Annexins
- Advanced Breast Cancer Therapies
- Nanoplatforms for cancer theranostics
- Cell death mechanisms and regulation
Guangxi Medical University
2010-2024
Guangxi Center for Disease Prevention and Control
2023
Kunming Medical University
2018
First Affiliated Hospital of GuangXi Medical University
2010-2014
Shanghai Jiao Tong University
2008-2010
Inner Mongolia University
2010
Ministry of Education of the People's Republic of China
2010
Beijing Tongren Hospital
2009
Capital Medical University
2009
XinHua Hospital
2008
Abstract Lung ischemia/reperfusion injury (LIRI) is a complex pathophysiological process, with the histopathological hallmark of neutrophils migrating into lungs. Neutrophil extracellular traps (NETs) have been suggested to exert critical role in pathogenesis inflammation and infection humans animals, while exact functions underlying mechanisms NETs LIRI remain insufficiently elucidated. In this study, we investigated pore-forming protein gasdermin D (GSDMD) on release induced by lung (I/R)....
Abstract Colorectal cancer (CRC) is currently one of the commonest tumors and main reason for cancer-related deaths worldwide. It has been reported that long non-coding RNAs (lncRNAs) act as important indicators regulators in various cancers. There an urgent need to explore new lncRNA biomarkers CRC, well their functions molecular mechanisms. NALT1 implicated occurrence gastric (GC). However, detailed function mechanism CRC progress have not reported. In this study, RT-qPCR was conducted...
Morphine is not only an analgesic treating pain for patients with cancer but also a potential anticancer drug inhibiting tumor growth and proliferation. To gain better insight into the involvement of morphine in biological characteristics gastric cancer, we investigated effects on progression carcinoma cells expression some apoptosis-related genes including caspase-9, caspase-3, survivin NF-κB using MGC-803 human cell line. The viability was assessed by MTT assay, proliferation colony...
Propofol is widely used in paediatric anaesthesia and intensive care unit because of its essentially short‐acting anaesthetic effect. Recent data have shown that propofol induced neurotoxicity developing brain. However, the mechanisms are not extremely clear. To gain a better insight into toxic effects on hippocampal neurons, we treated cells at days vitro 7 (DIV 7), which were prepared from Sprague–Dawley embryos 18th day gestation, with (0.1–1000 μM) for 3 h. A significant decrease...
Background: Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological process activated by lung transplantation and acute injury. The p38 mitogen-activated protein kinase (MAPK) involved in breakdown of the endothelial barrier during LIRI, but mechanism still unclear. Therefore, we investigated function MAPK LIRI vivo vitro . Methods: Sprague–Dawley rats were subjected to with or without pretreatment inhibitor. was assessed using hematoxylin eosin staining, pulmonary blood–air...
Lung ischemia reperfusion injury (LIRI) is a complex pathophysiological process with high morbidity and mortality. An important characteristic of LIRI endothelial barrier dysfunction, although the mechanism involved in this remains unclear. VX765, specific caspase-1 inhibitor, has been shown to have protective effect against several diseases including sepsis, atherosclerosis, glial inflammatory disease. The objective study was determine whether VX765 had LIRI. results showed that lung...
Lung ischemia-reperfusion injury (LIRI) is a severe multifaceted pathological condition that can lead to poor patient outcome where oxidative stress and the resulting inflammatory response trigger exacerbate tissue damage in LIRI patients. Sirtuin3 (SIRT3), member of sirtuin family, protects against stress-related diseases. However, it remains unclear if how SIRT3 alleviates lung induced by ischemia/reperfusion (I/R). Our previous study showed structures were severely damaged at 6 h after...
Background. Colorectal cancer is a digestive tract malignant tumor, ranking the second mortality and third incidence worldwide. The abnormal expression of NEAT1 related to occurrence development colorectal cancer. However, specific mechanism mediated-inflammatory pathway in progression still unclear. Methods. In this study, patients was analyzed by bioinformatics. Clinical samples including peripheral blood tissues were collected for qRT-PCR, Western blot, immunohistochemistry assay. role...
<i>Background:</i> Gallbladder cancer is a common and lethal digestive malignancy which nonsensitive to routine chemotherapy. Doxorubicin (DOX) one of the major chemotherapeutic drugs for patients with gallbladder cancer. We tried evaluate if combined use somatostatin (SST) DOX could have synergistic effect in treatment <i>Methods:</i> Cells from human cell line GBC-SD were treated SST. Cell cycle analysis was determined by flow cytometry. Western blot performed...
Blepharophimosis-ptosis-epicanthus inversus syndrome (BPES) is an autosomal dominant of eyelid malformations with (type I) or without II) associated premature ovarian failure. Multiple mutations in the exon and putative core promoter region FOXL2 gene encoding a forkhead transcription factor have been linked to this disease. To examine whether contribute BPES Chinese patient population, we screened 33 patients from 18 families unknown types, together 57 healthy individuals, including 27...
Abstract Lung ischemia/reperfusion injury (LIRI) is a complex pathophysiological process, with the histopathological hallmark of neutrophils migratinginto lungs. Neutrophil extracellular traps (NETs) have been suggested to exert critical role in pathogenesis inflammation and infection human animals, while exact functions underlying mechanisms NETs LIRI remain insufficiently elucidated. In this study, we investigated pore-forming protein gasdermin D (GSDMD) on release induced by lung (I/R)....
LEF-1, lymphocyte enhancer-binding factor-1, is a member of the LEF-1/TCF (T cell-specific transcription factor) family high mobility group (HMG) factors. downstream Wnt/β-catenin signaling pathway. LEF-1 requires Wnt and stabilized β-catenin to express hair-specific keratin genes control hair differentiation. Tcf3/LEF-1 complex has key role in controlling skin stem cells Thus this study amplified cDNA by RTPCR from Inner Mongolia Cashmere Goat (Capra hircus) produce transgenic goat with...
Introduction: Dexamethasone (DEX), as an important enduring-effect glucocorticoid (GC), holds great promise in the field of lung ischemia-reperfusion injury (LIRI) comprehensive therapy owing to its immunomodulatory properties, such inducing apoptosis and cell cycle distribution. However, potent anti-inflammatory application is still restricted because multiple internal physiologic barriers. Methods: Herein, we developed upconversion nanoparticles (UCNPs) coated with photosensitizer/capping...
Objective To explore the effects of morphine on biological characters human gastric carcinoma cell line MGC-803. Methods MGC-803 cells were incubated with 0.1,10 or 1000 μmol/L morphine. The viability was determined by MTT assay at 12, 24, 36, 48, 60, 72 h after being and proliferation measured colony formation 7 days later.The cycle progression apoptosis assessed flow cytometry. ultrastructural changes observed under transmission electron microscopy. Results inhibited incubation Clones in...
Objective To investigate the effects of different doses propofol anesthesia on long-term cognitive function in neonatal rats.Methods One hundred 7-day-old male Sprague-Dawley rats,weighing 9-18 g,were randomly divided into 5 groups (n =20 each) ∶ control group (C group) and 25,50,100 200mg/kg (groups P1-4,respectively).Groups P1 P2 received intraperitoneal 25 50 mg/kg,respectively.Groups P3 P4 100 200 mg/kg,respectively,and after righting reflex completely recovered,an increment mg/kg was...