A5046196739- Microplastics and Plastic Pollution
- Carcinogens and Genotoxicity Assessment
- Graphene and Nanomaterials Applications
- MicroRNA in disease regulation
- Effects and risks of endocrine disrupting chemicals
- Drug-Induced Adverse Reactions
- Anesthesia and Neurotoxicity Research
- Air Quality and Health Impacts
- Nanoparticles: synthesis and applications
- bioluminescence and chemiluminescence research
- Mitochondrial Function and Pathology
- Contact Dermatitis and Allergies
- biodegradable polymer synthesis and properties
- Recycling and Waste Management Techniques
- Ion Transport and Channel Regulation
- Advanced biosensing and bioanalysis techniques
- Neuroscience and Neuropharmacology Research
- Circular RNAs in diseases
- Pharmaceutical and Antibiotic Environmental Impacts
- Neuroinflammation and Neurodegeneration Mechanisms
- Occupational exposure and asthma
- Amyotrophic Lateral Sclerosis Research
- RNA modifications and cancer
- Alzheimer's disease research and treatments
- Advanced Glycation End Products research
Southern Medical University
2018-2025
Zhujiang Hospital
2024-2025
National Medical Products Administration
2024-2025
Nagoya University
2011-2023
Guangzhou Medical University
2023
Guangdong Provincial Occupational Disease Prevention Hospital
2006-2018
Sun Yat-sen University
2017
Wuhan Prevention and Treatment Center for Occupational Diseases
2011-2012
Micro- and nanoplastic pollution has become a global environmental problem. Nanoplastics in the environment are still hard to detect because of analysis technology limitations. It is believed that when microplastics found environment, more undetected nanoplastics around. The current "microplastic exposure" fact mixture micro- exposures. Therefore, biological interaction between organisms among different sizes should not be neglected.We measured biodistribution three polystyrene (PS)...
Dapsone is used in the treatment of infections and inflammatory diseases. The dapsone hypersensitivity syndrome, which associated with a reported mortality 9.9%, develops about 0.5 to 3.6% persons treated drug. Currently, no tests are available predict risk syndrome.We performed genomewide association study involving 872 participants who had received as part multidrug therapy for leprosy (39 syndrome 833 controls), using log-additive single-nucleotide polymorphisms (SNPs) imputed HLA...
Abstract Exposure to micro‐ and nanoplastics (MNPs) is common because of their omnipresence in environment. Recent studies have revealed that MNPs may cause atherosclerosis, but the underlying mechanism remains unclear. To address this bottleneck, ApoE −/− mice are exposed 2.5–250 mg kg −1 polystyrene (PS‐NPs, 50 nm) by oral gavage with a high‐fat diet for 19 weeks. It found PS‐NPs blood aorta mouse exacerbate artery stiffness promote atherosclerotic plaque formation. activate phagocytosis...
Microplastics and nanoplastics (MNPs) are emerging environmental contaminants detected in human samples, have raised concerns regarding their potential risks to health, particularly neurotoxicity. This study aimed investigate the deleterious effects of polystyrene (PS-NPs, 50 nm) understand mechanisms inducing Parkinson's disease (PD)-like neurodegeneration, along with exploring preventive strategies.
Non-small cell lung cancer is the leading cause of related mortality worldwide, and adenocarcinoma (LUAD) one most common subtypes. The role N6-methyladenosine (m6A) modification in tumorigenesis drug resistance LUAD remains unclear. In this study, we evaluated effects vir-like m6A methyltransferase-associated protein (KIAA1429) depletion on proliferation, migration, invasion, cells, identified m6A-dependent downstream genes influenced by KIAA1429. We found that KIAA1429 activated Jun...
Micro- and nanoplastics (MNPs) homosalate (HMS) are ubiquitous emerging environmental contaminants detected in human samples. Despite the well-established endocrine-disrupting effects (EDEs) of HMS, interaction between MNPs HMS its impact on HMS-induced EDEs remain unclear.
1,2-Dichloroethane (1,2-DCE) is a prevalent environmental contaminant, and our study revealed its induction of testicular toxicity in mice upon subacute exposure. Melatonin, prominent secretory product the pineal gland, has been shown to offer protection against pyroptosis male reproductive toxicity. However, exact mechanism underlying 1,2-DCE-induced comprehensive extent melatonin's protective effects this regard remain largely unexplored. Therefore, we sequenced testis piRNAs exposed...
Biodegradable plastics, hailed for their environmental friendliness, may pose unforeseen risks as they undergo gastrointestinal degradation, forming oligomer nanoplastics. Despite this, the influence of degradation on potential human toxicity biodegradable plastics remains poorly understood. To this end, impact murine in vivo digestive system is investigated biotransformation, biodistribution, and PLA polymer MPs. Through a 28-day repeated oral gavage study mice, it revealed that...
Oral ingestion is the primary route for human exposure to nanoplastics, making gastrointestinal tract one of first and most impacted organs. Given presence gut–brain axis, a crucial concern arises regarding potential impact intestinal damage on neurotoxic effects nanoplastics (NPs). The intricate mechanisms underlying NP-induced neurotoxicity through microbiome–gut–brain axis necessitate further investigation. To address this, we used mice specifically engineered with nuclear factor...
The widespread environmental presence of nanoplastics (NPs) raises significant concerns about their health impacts, particularly on the gastrointestinal system, as NPs are primarily ingested. While previous studies have linked NP-induced intestinal toxicity to oxidative stress and reactive oxygen species (ROS) accumulation, specific mechanisms cell death remain unclear. Here, we showed that environmentally relevant concentrations polystyrene (PS-NPs) induced ferroptosis, a form lipid...
Triclosan (TCS) has garnered significant attention due to its widespread use and associated endocrine-disrupting effects. However, impact on the neuroendocrine system underlying mechanisms remain poorly understood. Here, we established correlations between TCS exposure serum sex hormone levels in participants of National Health Nutrition Examination Survey (NHANES). Additionally, investigated TCS's influence using adult zebrafish exposed environmentally relevant concentrations (0.361–48.2...
Microplastics are prevalent emerging pollutants with widespread distribution in air, land and water. They have been detected human stool, blood, lungs, placentas. However, fetal microplastic exposure remains largely under-studied. To assess exposure, we investigated microplastics using 16 meconium samples. We used hydrogen peroxide (H2O2), nitric acid (HNO3) a combination of Fenton's reagent HNO3 pretreatment methods respectively to digest the sample. analyzed pretreated samples an...
Microplastics and nanoplastics (MNPs) originating from plastic pollution pose potential threats to cardiovascular health, with prior studies linking MNPs atherosclerosis. Our earlier research elucidated how enhance macrophages' phagocytic activity, leading the formation of foam cells an elevated risk However, specific influence on smooth muscle (SMCs) in context MNP-induced atherosclerosis remains poorly understood. In this study, ApoE knockout (ApoE
Human Herpesvirus 6 Reactivation in Trichloroethylene‐exposed Workers Suffering from Generalized Skin Disorders Accompanied by Hepatic Dysfunction: Hanlin H uang , et al . Hospital for Occupational Diseases Control of Guangdong Province, P. R. China —Idiosyncratic generalized skin disorders resembling serious drug hypersensitivities have reportedly occurred after occupational exposure to trichloroethylene. However, factors associated with the remain unknown except trichloroethylene exposure....
Idiosyncratic generalized skin disorders complicated by hepatitis, which resemble severe drug hypersensitivities, occur sporadically in workers exposed to trichloroethylene (TCE) China. However, it has been a matter of controversy whether the solvent itself, not its impurities or stabilizers, can cause hypersensitivity reactions not. This study aimed characterize exposure hospitalized patients and their healthy colleagues. TCE metabolites were measured urine 19 suffering from disorders. To...