A5100632513- Acute Ischemic Stroke Management
- Liver physiology and pathology
- Oral Health Pathology and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Oral and gingival health research
- Fibroblast Growth Factor Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Stroke Rehabilitation and Recovery
- Oral and Maxillofacial Pathology
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- S100 Proteins and Annexins
- Hepatitis B Virus Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Angiogenesis and VEGF in Cancer
- Nerve injury and regeneration
- Neurological Disorders and Treatments
- Mesenchymal stem cell research
- Bone and Dental Protein Studies
- Cancer-related molecular mechanisms research
- Cervical and Thoracic Myelopathy
- Reconstructive Surgery and Microvascular Techniques
Guangzhou Medical University
2015-2025
Zhongshan Hospital
2025
Fudan University
2012-2025
China Pharmaceutical University
2025
Second Affiliated Hospital of Zhejiang University
2024-2025
General Hospital of Shenyang Military Region
2018-2023
Command Hospital
2021-2022
Stomatology Hospital
2015-2021
Xuzhou Medical College
2020-2021
Second People’s Hospital of Huai’an
2020-2021
Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that mainly transfers from human to via and gastrointestinal routes. The S-glycoprotein in the virus key factor for entry of SARS-CoV-2 into cell, which contains two functional domains: S1 an angiotensin-converting enzyme (ACE2) receptor binding domain, S2 necessary fusion cell membranes. Moreover, it has been reported ACE2 likely be SARS-CoV-2. In addition, mRNA level...
Accumulating evidence indicates that oxidative stress plays a critical role in Parkinson's disease (PD). Our previous work has shown 100 Hz electro-acupuncture (EA) stimulation at ZUSANLI (ST36) and SANYINJIAO (SP6) protects neurons the substantia nigra pars compacta from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity male C57BL/6 mice, model of PD. In present study we administered EA two acupoints to MPTP-lesioned mice for 12 sessions starting day prior first MPTP injection....
Molecular glue degraders induce "undruggable" protein degradation by a proximity-induced effect. Inspired the clinical success of immunomodulatory drugs, we aimed to design novel molecular targeting GSPT1. Here, report series GSPT1 degraders. LYG-409, 2H-chromene derivative, was identified as potent, selective, and orally bioavailable degrader with excellent antitumor activity in vivo (anti-Acute Myeloid Leukemia MV4–11 xenograft model: TGI = 94.34% at 30 mg/kg; prostate cancer 22Rv1 104.49%...
ABSTRACT Aim To investigate the effects of hyperuricemia on periodontitis and underlying mechanisms by establishing combined animal cell models. Methods A mouse model was established potassium oxonate injection, with sodium carboxymethylcellulose treatment serving as controls. Both models were treated or without induction ( n = 10/group). RAW264.7 macrophages THP‐1‐derived stimulated Porphyromonas gingivalis ‐lipopolysaccharide in presence normal excessive concentrations uric acid....
Background Hand-food-mouth disease (HFMD) cases can be fatal. These develop rapidly, and it is important to predict the severity of HFMD from mild fatal identify risk factors for HFMD. The objective this study was correlate levels serum inflammatory cytokines with severity. Methods This designed as a nested serial case-control study. data collected included general information, clinical symptoms signs, laboratory findings cytokine levels. Results IL-4, IL-6, IL-10, TNF-α IFN-γ in patients...
BACKGROUND:The aim of this study was to compare the clinical and radiological outcomes 3D-printed artificial vertebral body vs titanium mesh cage in repairing bone defects for single-level anterior cervical corpectomy fusion (ACCF). MATERIAL AND METHODS:A total 51 consecutive patients who underwent ACCF Huai'an Second People's Hospital from July 2017 August 2020 were retrospectively reviewed. According implant materials used, divided into a group (3D-printed group) (n=20; 12 males, 8...
Intravenous recombinant tissue plasminogen activator (r-tPA) and urokinase (UK) are both recommended for the treatment of acute ischaemic stroke (AIS) in China, but with few comparative outcome data being available. We aimed to compare outcomes these two thrombolytic agents patients within 4.5 hours onset AIS routine clinical practice China.A pre-planned, prospective, nationwide, multicentre, real-world registry consecutive (age ≥18 years) who received r-tPA or UK symptom according local...
Abstract Background Leading to a sustained epidemic spread with >2,000,000 confirmed human infections, including >100,000 deaths, COVID-19 was caused by SARS-CoV-2 and resulted in acute respiratory distress syndrome (ARDS) sepsis, which brought more challenges the patient’s treatment. The S-glycoprotein, recognized as key factor for entry of into cell, contains two functional domains: an ACE2 receptor binding domain second necessary fusion coronavirus cell membranes. FURIN activity,...
Abstract Background and Objective Clinical studies found high levels of hepatocyte growth factor (HGF) expression in patients with periodontitis. Studies suggest that HGF plays an important role periodontitis, is involved inflammation, modulates alveolar bone integrity This study aims to investigate the effects mechanisms progression experimental Methods We used silk thread ligation induce periodontitis HGF‐overexpressing transgenic (HGF‐Tg) wild‐type C57BL/6J mice. The overexpression on...
Abstract Background Endothelial dysfunction is a well documented evidence for the onset of atherosclerosis and other cardiovascular diseases. Lipids disorder among main risk factors endothelial in these Steroidogenic acute regulatory protein (StAR), one cholesterol transporters, plays an important role maintenance intracellular lipid homeostasis. However, effect StAR on not understood. Palmitic acid (PA) has been shown to decrease eNOS activity induce inflammation, both are causes...
Decreasing hepatic fibrosis remains one of the major therapeutic challenges in hepatology. The present study aims to evaluate effect Endostar on both CCl4-induced liver mice and a stellate cell (HSC) line. Two main models were studied: (i) model was induced BALB/c using CCl4 by intraperitoneal injection for six weeks. Six animal groups group 1: normal animals; 2: fibrosis; 3: + 20 mg/kg/d, weeks; 4: 10 5: four 6: weeks corresponded different doses duration administration. Liver evaluated...
Rationale The evidence of intravenous thrombolysis in patients with not clearly disabling minor stroke (low National Institutes Health Stroke Scale 0–5) is still insufficient. Recent early terminated PRISMS trial could provide definitive conclusion, although suggesting the similar functional outcome between alteplase and aspirin groups. two clinical trials a for superiority dual antiplatelet to mono-antiplatelet stroke. However, efficacy safety vs. treatment acute are known. Aim To explore...
BACKGROUND:This study aimed to evaluate the efficacy of a porous polyoxymethylene thermoplastic regulator combined with three-dimensional (3D) printed template guide pedicle needle insertion in patients undergoing percutaneous screw fixation (PPSF) for thoracolumbar fracture. MATERIAL AND METHODS:Forty were randomly divided into group A, treated using 3D template, and B, who underwent conventional PPSF. Data recorded included number screws successfully inserted on first attempt, attempts,...
Previous studies suggest the benefit of dual antiplatelet therapy (DAPT) for acute ischemic stroke with large artery atherosclerosis (LAA) etiology, but there is no study about effect DAPT plus anticoagulant in this population.
Bone marrow mononuclear cell (BMMC) transplantation has been shown to facilitate tissue and organ regeneration repair. BMMC may be a potential therapy for acute liver failure, its effect might further improved. Hepatocyte growth factor (HGF) plays an important role in development, ameliorate hepatic fibrosis or cirrhosis animal models. We therefore explored synergistic of the co-application HGF BMMCs following carbon tetrachloride (CCl(4))-induced injury.We established murine failure model...
Oral lichen planus (OLP) is a chronic inflammatory oral mucosal disease in which comprehensive inflammation-related cytokines are involved. These commonly produced by immune cells and specific nonimmune including keratinocytes, endothelial fibroblasts. This raises the question of whether fibroblasts OLP lesions contribute to process upon simulation.Primary cultured lichen-planus-associated (OLP AFs, n = 5) normal buccal (NFs, were examined immunohistochemistry, Western blotting reverse...
Hand, foot and mouth disease (HFMD) is an infectious that affects mostly children. The children with HFMD also have other immune metabolic disorders. However, the association of these disorders severity has not yet been determined. In this study, we used a case-control study design to examine correlation development in 406 mild severe patients were recruited divided into different subgroups based on number days from initial onset time hospitalization (1, 2, 3, 4, ≥5 days). Logistic...
The purpose of this study was to compare the preoperative radiographic features degenerative lumbar spondylolisthesis (DLS) with and without local coronal imbalance (LCI) investigate surgical outcomes transforaminal interbody fusion (TLIF) in treatment DLS LCI at level. scoliotic disc wedging and/or lateral listhesis same involved segment, as well LCI, constitutes a distinct subgroup. However, previous studies concerning focused mainly on sagittal profiles. There is paucity valid data...