A5039632183- Pain Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Ion channel regulation and function
- Pain Management and Placebo Effect
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Botulinum Toxin and Related Neurological Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Musculoskeletal pain and rehabilitation
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Healthcare and Venom Research
- Ion Channels and Receptors
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neural Engineering
- Myofascial pain diagnosis and treatment
- Neurotransmitter Receptor Influence on Behavior
- Olfactory and Sensory Function Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Retinal Development and Disorders
Wuhan University
2009-2025
Peking University
2015-2024
National Health and Family Planning Commission
2015-2024
Nantong University
2019-2024
Beijing Academy of Science and Technology
2024
University of Electronic Science and Technology of China
2022-2024
King University
2019
Ministry of Education
2019
Bioscience Research
2017
Ministry of Education of the People's Republic of China
2008-2013
Abstract Pain is estimated to affect more than 20% of the global population, imposing incalculable health and economic burdens. Effective pain management crucial for individuals suffering from pain. However, current methods assessment treatment fall short clinical needs. Benefiting advances in neuroscience biotechnology, neuronal circuits molecular mechanisms critically involved modulation have been elucidated. These research achievements incited progress identifying new diagnostic...
We and others have previously demonstrated that nociception in the mouse is heritable. A genetic correlation analysis of 12 common measures among a set inbred strains revealed three major clusters (or 'types') this species. In present study, we re-evaluated types their interrelatedness using ten additional assays hypersensitivity, including: thermal (tail withdrawal from 47.5°C water or −15°C ethanol; tail flick radiant heat), two chemical spontaneous (bee venom test; capsaicin test)...
Background: The present study aims to investigate the role of transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons chronic pain including thermal hyperalgesia and mechanical allodynia. Chronic inflammatory nociception rats was produced by intraplantar injection complete Freund's adjuvant (CFA) data collected until day 28 following injection. Results: Thermal evident from with peak at 7, while allodynia persisted 14 greatest 7. Intrathecal administration AMG...
Cognitive behavioral therapy, such as environmental enrichment combined with voluntary exercise (EE-VEx), is under active investigation an adjunct to pharmaceutical treatment for chronic pain. However, the effectiveness and underlying mechanisms of EE-VEx remain unclear. In mice intraplantar injection complete Freund's adjuvant, our results revealed that alleviated perceptual, affective, cognitive dimensions inflammatory These effects on pain were contingent occurrence adult neurogenesis in...
Chemokines are important mediators in immune responses and inflammatory processes. Calcitonin gene-related peptide (CGRP) is produced dorsal root ganglion (DRG) neurons. In this study, CGRP radioimmunoassay was used to investigate whether the chemokines CCL2 CXCL1 could trigger release from cultured DRG neurons of neonatal rats and, if so, which cellular signaling pathway involved. The results showed that (∼5–100 ng/ml) evoked intracellular calcium elevation a pertussis toxin (PTX)-sensitive...
Background There is current interest in understanding the molecular mechanisms of tumor-induced bone pain. Accumulated evidence shows that endogenous formaldehyde concentrations are elevated blood or urine patients with breast, prostate bladder cancer. These cancers frequently associated cancer pain especially after metastasis. It well known transient receptor potential vanilloid 1 (TRPV1) participates The present study aims to demonstrate tumor tissue-derived induces via TRPV1 activation...
Peripheral nerve injury causes neuropathic pain including mechanical allodynia and thermal hyperalgesia due to central peripheral sensitization. Spontaneous ectopic discharges derived from dorsal root ganglion (DRG) neurons the sites of are a key factor in initiation this Numerous studies have focused primarily on DRG neurons; however, injured axons themselves likely play an equally important role. Previous rats with spinal ligation (SNL) showed that hyperpolarization-activated cyclic...
Summary Suppression of KCNQ/M channels in dorsal root ganglia neurons is associated with neuronal hyperexcitability and cancer-induced bone pain rats. Bone cancer has a strong impact on the quality life patients, but difficult to treat. Better understanding pathogenic mechanisms underlying will likely lead development more effective treatments. In present study, we investigated whether inhibition contributed primary sensory pathogenesis pain. By using rat model based intratibial injection...
Recent studies show that formaldehyde participates in DNA demethylation/methylation cycle. Emerging evidence identifies neuronal activity induces global demethylation and re-methylation; methylation is a critical step for memory formation. These data suggest endogenous may intrinsically link learning-responsive status Here, we report during spatial formation process, training an initial subsequent re-methylation associated with hippocampal elevation then decline to baseline level Sprague...
Despite high prevalence of anxiety accompanying with chronic pain, the mechanisms underlying pain-related are largely unknown. With its well-documented role in pain and emotion processing, amygdala may act as a key player pathogenesis neuropathic anxiety. Pain-related plasticity sensitization CeA (central nucleus amygdala) neurons have been shown several models pain. In addition, firing pattern spike output can powerfully affect functional brain nucleus, GABAergic crucial modulation neuronal...
Abstract Exacerbation of pain by chronic stress and comorbidity with stress-related psychiatric disorders, including anxiety depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether forced swim (CFSS)–induced exacerbation neuropathic is mediated integration stress-affect–related information nociceptive in central nucleus amygdala (CeA). We first demonstrated that CFSS indeed produces both depressive-like...
Pain involves an intrinsically dynamic connectome characterized by fluctuating spontaneous brain activity and continuous neuroplastic changes of relevant circuits. Activity in the hippocampus-medial prefrontal cortex (mPFC) pathway has been suggested to correlate with pain chronicity, but causal evidence is lacking. Here we combine longitudinal vivo electrophysiological recording behavioral testing show that persistent disrupts ventral hippocampal CA1-infralimbic (vCA1-IL) connectivity...
Pain chronicity involves unpleasant experience in both somatosensory and affective aspects, accompanied with the prefrontal cortex (PFC) neuroplastic alterations. However, whether specific PFC neuronal ensembles underlie pain remains elusive. Here we identify a nociceptive ensemble dorsomedial (dmPFC), which shows prominent reactivity to stimuli. We observed that this distinct molecular characteristics is densely connected pain-related regions including basolateral amygdala (BLA) lateral...
Chronic pain is one of the most significant medical problems throughout world. Recent evidence has confirmed hippocampus as an active modulator chronicity, but underlying mechanisms remain unclear. Using in vivo electrophysiology, we identify a neural ensemble ventral hippocampal CA1 (vCA1) that shows inhibitory responses to noxious not innocuous stimuli. Following peripheral inflammation, this becomes responsive stimuli, representing hypersensitivity. Mimicking inhibition vCA1 neurons using...
Abstract Spatial transcriptomics (ST) data have emerged as a pivotal approach to comprehending the function and interplay of cells within intricate tissues. Nonetheless, analyses ST are restricted by low spatial resolution limited number ribonucleic acid transcripts that can be detected with several popular techniques. In this study, we propose both above issues significantly improved introducing deep graph co-embedding framework. First, establish self-supervised, co-graph convolution...
The present study aimed to systematically observe the change of vanilloid receptor 1 (VR1) during inflammatory nociception induced by intraplantar injection complete Freund's adjuvant (CFA) into left hind paw in rats. Hot plate latency (HPL) was used evaluate resulting thermal hyperalgesia and immunohistochemistry VR1 expression dorsal root ganglion spinal cord horn. Results showed that HPL decreased from day 28 after CFA injection, with shortest at 14. correspondingly increased 21 peak 14,...
The large, medium-sized, and small neurons of the dorsal root ganglion (DRG) have different functions in processing various senses. Hyperpolarization-activated, cyclic nucleotide-gated channels (HCN) contribute greatly to neuronal excitability. In present study, which used whole-cell patch clamp techniques immunohistochemical staining methods, electrophysiological properties DRG were systematically compared, roles HCN-1, -2, -4 examined. main results as follows. 1) large had significantly...