A5038695009- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Olfactory and Sensory Function Studies
- Tryptophan and brain disorders
- Photoreceptor and optogenetics research
- Metabolomics and Mass Spectrometry Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Traumatic Brain Injury and Neurovascular Disturbances
- Indoor Air Quality and Microbial Exposure
- Neuroscience and Neuropharmacology Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Laser Applications in Dentistry and Medicine
- Biochemical effects in animals
- Air Quality and Health Impacts
- Microbial metabolism and enzyme function
- High Altitude and Hypoxia
- Eicosanoids and Hypertension Pharmacology
- Neuroscience of respiration and sleep
- Circadian rhythm and melatonin
- Neuroscience and Neural Engineering
- Dementia and Cognitive Impairment Research
- Coenzyme Q10 studies and effects
- Health, Environment, Cognitive Aging
Wenzhou Medical University
2021-2025
Zhejiang Lab
2023-2025
Jinzhou Kangning Hospital
2022-2025
Beijing Geriatric Hospital
2024-2025
Ministry of Science and Technology
2024
Capital Medical University
2014-2023
Jiangsu University
2023
Shandong University
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Chinese Institute for Brain Research
2014-2019
Background There is current interest in understanding the molecular mechanisms of tumor-induced bone pain. Accumulated evidence shows that endogenous formaldehyde concentrations are elevated blood or urine patients with breast, prostate bladder cancer. These cancers frequently associated cancer pain especially after metastasis. It well known transient receptor potential vanilloid 1 (TRPV1) participates The present study aims to demonstrate tumor tissue-derived induces via TRPV1 activation...
Recent studies show that formaldehyde participates in DNA demethylation/methylation cycle. Emerging evidence identifies neuronal activity induces global demethylation and re-methylation; methylation is a critical step for memory formation. These data suggest endogenous may intrinsically link learning-responsive status Here, we report during spatial formation process, training an initial subsequent re-methylation associated with hippocampal elevation then decline to baseline level Sprague...
Although Alzheimer's disease (AD) was first described over 100 years ago, there is still no suitable biomarker for diagnosing AD in easily collectable samples (e.g., blood plasma, saliva, and urine). Here, we investigated the relationship between morning urine formaldehyde concentration cogniti ve impairment patients with post-stroke dementia (PSD) or this cross-sectional survey 7 years. Cognitive abilities of study participants (n = 577, four groups: 231 controls, 61 stroke, 65 PSD, 220 AD)...
Pharmacological therapies to treat Alzheimer's disease (AD) targeting "Aβ" have failed for over 100 years. Low levels of laser light can disassemble Aβ. In this study, we investigated the mechanisms that Aβ-blocked extracellular space (ECS) induces memory disorders in APP/PS1 transgenic mice and addressed whether red (RL) at 630 nm rescues cognitive decline by reducing Aβ-disturbed flow interstitial fluid (ISF).We compared heating effects on brains rats illuminated with 630, 680, 810 40...
Brain diseases present a significant obstacle to both global health and economic progress, owing their elusive pathogenesis the limited effectiveness of pharmaceutical interventions. Phototherapy has emerged as promising non-invasive therapeutic modality for addressing age-related brain disorders, including stroke, Alzheimer's disease (AD), Parkinson's (PD), among others. This review examines recent progressions in phototherapeutic Firstly, article elucidates various wavelengths visible...
A norepinephrine (NE) deficiency has been observed in aged rats and patients with Alzheimer's disease is thought to cause cognitive disorder. Which endogenous factor induces NE depletion, however, largely unknown. In this study, we investigated the effects of aging-associated formaldehyde (FA) on inactivation vitro vivo, memory behaviors rodents. The results showed that age-related DNA demethylation led hippocampal FA accumulation, when occurred, content was reduced healthy male different...
Abstract Gaseous formaldehyde is an organic small molecule formed in the early stages of earth’s evolution. Although toxic high concentrations, plays important role cellular metabolism and, unexpectedly, found even healthy brain. However, its pathophysiological functions brain are unknown. Here, we report that under physiological conditions, spatial learning activity elicits rapid generation from mitochondrial sarcosine dehydrogenase (SARDH). We find elevated levels facilitate memory...
Both exogenous gaseous and liquid forms of formaldehyde (FA) can induce depressive-like behaviors in both animals humans. Stress neuronal excitation elicit brain FA generation. However, whether endogenous participates depression occurrence remains largely unknown. In this study, we report that midbrain derived from lipopolysaccharide (LPS) is a direct trigger depression. Using an acute depressive model mice, found one-week intraperitoneal injection (i.p.) LPS activated...
Abstract Although MK801-induced NMDA receptor (NMDAR) hypofunction mimics schizophrenia symptoms, the exact factors causing NMDAR inhibition are unknown. Unexpectedly, external stress elicits formaldehyde (FA) generation; FA can induce depression and cognitive impairments by blocking NMDARs. This study explores using injection to establish a schizophrenia-like model in mice. Here, we reported that stress-derived induces behaviors. Four experimental methods were used symptoms wild-type mice:...
Patients with type 2 diabetes mellitus (T2DM) often develop cognitive impairments and have an increased risk of developing Alzheimer's disease. Hyperglycemia is a major characteristic T2DM, but how elevated glucose levels lead to decline remains elusive. Here, we report that patients T2DM mutations in the formaldehyde (FA)-degrading enzyme aldehyde dehydrogenase (ALDH2) gene had higher FA more severe dementia. Injection induced hyperglycemia deficits rats. Ablation expression ALDH2, main...
Abstract Introduction Acute high‐altitude hypoxia exposure causes multiple adverse neurological consequences. However, the exact mechanisms are still unclear, and there is no targeted treatment with few side effects. Excessive cerebral formaldehyde (FA) impairs numerous functions, can be eliminated by nano‐packed coenzyme Q10 (CoQ10). Aims In this study, we aimed to investigate whether FA was accumulated after hypobaric exposure, further explored preventative effect of CoQ10 through...
Brain diseases including brain tumor, Alzheimer's disease, Parkinson's etc. are difficult to treat. The blood-brain barrier (BBB) is a major obstacle for drug delivery into the brain. Although nano-package and receptor-mediated of nanomedicine markedly increases BBB penetration, it yet did not extensively improve clinical cure rate. Recently, extracellular space (ECS) interstitial fluid (ISF) drainage in ECS have been found determine whether dissolved ISF can reach its target cells. Notably,...
Alzheimer's disease (AD) is the most common form of dementia, affecting millions people worldwide. Increasing evidence suggests that formaldehyde might be one various pathological mechanisms involved in process AD onset. Here, we use
Although air pollutions cause human diseases, no epidemiological study has investigated the effect of exposure to pollutants on brain diseases in general population. Our objective was examine association between tropospheric airborne and health risk global burden, especially, attributable indoor formaldehyde (FA) pollution China. The data pollutants, such as: CO, NO, O3, PM2.5 or PM10, SO2, FA China, 2013-2019, which were derived from database satellite remote-sensing, first calculated then...