A5004861879- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Anesthesia and Neurotoxicity Research
- Mitochondrial Function and Pathology
- Stress Responses and Cortisol
- Congenital heart defects research
- Neurological Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Pain Mechanisms and Treatments
- Cancer, Hypoxia, and Metabolism
- Air Quality and Health Impacts
- Neuroscience and Neural Engineering
- Neonatal and fetal brain pathology
- Air Quality Monitoring and Forecasting
- Adipose Tissue and Metabolism
- Genomic variations and chromosomal abnormalities
- Anesthesia and Sedative Agents
- Biochemical effects in animals
- Neuroendocrine regulation and behavior
- Alzheimer's disease research and treatments
- Nerve injury and regeneration
- MicroRNA in disease regulation
- RNA Research and Splicing
Wenzhou Medical University
2023-2025
Zhejiang Lab
2023-2025
Jinzhou Kangning Hospital
2025
Southwest University
2022-2025
Nanjing Agricultural University
2022-2025
Texas A&M Health Science Center
2023
Texas A&M University
2023
Macao Polytechnic University
2023
University at Buffalo, State University of New York
2017-2022
Wuhan University
2022
Long-term potentiation (LTP) of synaptic strength between hippocampal neurons is associated with learning and memory, LTP dysfunction thought to underlie memory loss. can be temporally mechanistically classified into decaying (early-phase) nondecaying (late-phase) LTP. While the nature depend on protein synthesis contribute maintenance, little known about mechanisms roles Here, we demonstrated that inhibiting endocytosis postsynaptic α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid...
Exposure to prolonged stress in critical developmental periods induces heightened vulnerability psychiatric disorders, which may have sex-specific consequences. Here we investigate the neuronal circuits mediating behavioral changes mice after chronic adolescent social isolation stress. Escalated aggression is exhibited stressed males, while withdrawal shown females. In vivo multichannel recordings of free-moving animals indicate that pyramidal neurons prefrontal cortex (PFC) from males...
Exposure to addictive drugs triggers synaptic plasticity in reward-related brain regions, such as the midbrain, nucleus accumbens and prefrontal cortex. Effects of chronic drug exposure on other areas have not been fully investigated. Here, we characterize motor cortex after methamphetamine self-administration rats. We show that this causes a loss corticostriatal rat slices impaired learning rotarod task. These findings are paralleled by observation lack transcranial magnetic...
Microdeletion of the human 16p11.2 gene locus has been linked to autism spectrum disorder (ASD) and intellectual disability confers risk for a number other neurodevelopmental deficits. Transgenic mice carrying deletion (<i>16p11</i><sup>+/−</sup>) display phenotypes reminiscent those in patients with syndrome, but molecular mechanisms treatment strategies these remain unknown. In this study, we have found that both male female <i>16p11</i><sup>+/−</sup> exhibit deficient NMDA receptor...
ASH1L, a histone methyltransferase, is identified as top-ranking risk factor for autism spectrum disorder (ASD), however, little known about the biological mechanisms underlying link of ASH1L haploinsufficiency to ASD. Here we show that expression and H3K4me3 level are significantly decreased in prefrontal cortex (PFC) postmortem tissues from ASD patients. Knockdown Ash1L PFC juvenile mice induces downregulation genes associated with ASD, intellectual disability (ID) epilepsy. These...
Highlights•Repeated morphine and fentanyl injections potentiate IPSCdMSN→GPh transmission•Repeated administration potentiates IPSCdMSN→SNc transmission•Fentanyl recruits striatal neurons that encode contextual memory•Striatal MOR+ drive withdrawal-induced negative affectSummaryWithdrawal from chronic opioid use often causes hypodopaminergic states affect, which may relapse. Direct-pathway medium spiny (dMSNs) in the patch compartment contain μ-opioid receptors (MORs). It remains unclear how...
Corticosteroid stress hormones exert a profound impact on cognitive and emotional processes. Understanding the neuronal circuits that are altered by chronic is important for counteracting detrimental effects of in brain region- cell type-specific manner. Using chemogenetic tool, Designer Receptors Exclusively Activated Drugs (DREADDs), which enables remote, noninvasive long-lasting modulation cellular activity signal transduction discrete populations vivo, we sought to identify specific...
Sleep deprivation during pregnancy is a serious public health problem as it can affect the of pregnant women and newborns. However, not well studied whether sleep at different stages has similar effects on emotional cognitive functions offspring, if so, potential cellular mechanisms also remain poorly understood. In present study, rats were subjected to for 6 h per day by gentle handling first (gestational days 1–7), second 8–14) third trimester 15–21) pregnancy, respectively. The...
Alzheimer's disease (AD) is a chronic neurodegenerative leading to dementia, which characterized by progressive memory loss and other cognitive dysfunctions. Recent studies have attested that noninvasive repetitive transcranial magnetic stimulation (rTMS) may help improve function in patients with AD. However, the majority of these focused on effects high-frequency rTMS function, little known about low-frequency AD treatment. Furthermore, potential mechanisms improvement learning also remain...
Abstract Gaseous formaldehyde is an organic small molecule formed in the early stages of earth’s evolution. Although toxic high concentrations, plays important role cellular metabolism and, unexpectedly, found even healthy brain. However, its pathophysiological functions brain are unknown. Here, we report that under physiological conditions, spatial learning activity elicits rapid generation from mitochondrial sarcosine dehydrogenase (SARDH). We find elevated levels facilitate memory...
In the context of increasing urbanization, understanding influence urban spatial layouts on microclimatic conditions has become crucial, particularly in high-density reclaimed areas like those Macao Peninsula, where optimizing thermal comfort is essential for enhancing residents’ quality life and promoting sustainable development. For this study, we assessed plots Peninsula a detailed case study. We conducted on-site measurements along with simulations using ENVI-met software, comparing...
Twenty-two coumarins and twenty-six flavonoids were quantitated in fingered citron different growth periods. Limettin was the top coumarin, diosmin highest flavonoid, followed by hesperidin. Antioxidant evaluation DPPH, ABTS, FRAP indicated extracts of three periods all showed good antioxidant activity, which positively correlated with concentration extracts. The oxidative stress model RAW264.7 cells from effectively reduced contents NO, MDA, ROS increased activity SOD, thereby alleviating...
Neonatal isolation is a widely accepted model to study the long-term behavioral changes produced by early life events. However, it remains unknown whether neonatal can induce autistic-like behaviors, and if so, pharmacological treatment overcome it. Here, we reported that newborn rats subjected individual isolations from their mother nest for 1 h per day postnatal days 1-9 displayed apparent symptoms including social deficits, excessive repetitive self-grooming behavior, increased anxiety-...
Patients with type 2 diabetes mellitus (T2DM) often develop cognitive impairments and have an increased risk of developing Alzheimer's disease. Hyperglycemia is a major characteristic T2DM, but how elevated glucose levels lead to decline remains elusive. Here, we report that patients T2DM mutations in the formaldehyde (FA)-degrading enzyme aldehyde dehydrogenase (ALDH2) gene had higher FA more severe dementia. Injection induced hyperglycemia deficits rats. Ablation expression ALDH2, main...
Patients with autism spectrum disorder (ASD) display abnormalities in neuronal development, synaptic function and neural circuits. The imbalance of excitatory inhibitory (E/I) transmission has been proposed to cause the main behavioral characteristics ASD. Repetitive transcranial magnetic stimulation (rTMS) can directly or indirectly induce excitability plasticity changes brain noninvasively. However, whether rTMS ameliorate autistic-like behaviors animal model via regulating balance E/I is...