A5000147267- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cervical Cancer and HPV Research
- Neuroscience and Neuropharmacology Research
- Hippo pathway signaling and YAP/TAZ
- Bioactive Natural Diterpenoids Research
- Nerve injury and regeneration
- Microtubule and mitosis dynamics
- Alzheimer's disease research and treatments
- Colorectal and Anal Carcinomas
- Alkaline Phosphatase Research Studies
- Ferroptosis and cancer prognosis
- Phytochemistry and Bioactive Compounds
- Parkinson's Disease Mechanisms and Treatments
- Urinary and Genital Oncology Studies
- Mesenchymal stem cell research
- RNA Research and Splicing
- Reproductive tract infections research
- Cancer Genomics and Diagnostics
- Reproductive System and Pregnancy
- Endoplasmic Reticulum Stress and Disease
- Tryptophan and brain disorders
- Endometrial and Cervical Cancer Treatments
- Axon Guidance and Neuronal Signaling
Huazhong University of Science and Technology Hospital
2024
Huazhong University of Science and Technology
2022-2023
Wuhan Children's Hospital
2022
Chongqing Medical University
2014-2021
Children's Hospital of Chongqing Medical University
2014-2021
Hainan Medical University
2019-2021
Hainan Medical College Hospital
2019
Tongde Hospital of Zhejiang Province
2014
Long-term potentiation (LTP) of synaptic strength between hippocampal neurons is associated with learning and memory, LTP dysfunction thought to underlie memory loss. can be temporally mechanistically classified into decaying (early-phase) nondecaying (late-phase) LTP. While the nature depend on protein synthesis contribute maintenance, little known about mechanisms roles Here, we demonstrated that inhibiting endocytosis postsynaptic α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid...
Abstract Convincing evidence supports the premise that reducing α-synuclein levels may be an effective therapy for Parkinson’s disease (PD); however, there has been lack of a clinically applicable therapeutic strategy. This study was undertaken to develop blood-brain barrier and plasma membrane-permeable knockdown peptide, Tat-βsyn-degron, have potential. The peptide effectively reduced level via proteasomal degradation both in cell cultures animals. Tat-βsyn-degron decreased aggregates...
Objectives: Calotropin (CTP), a natural product isolated from Calotropis gigantea, has been identified as potential anticancer agent. In this study, we aimed to investigate the effect CTP on colorectal cancer and role of Yes-associated protein (YAP) in CTP-inhibited cell proliferation. Methods: Cell viability proliferation were detected by MTT BrdU assay. Western blotting immunofluorescence performed determine CTP-induced YAP dephosphorylation nuclear localization. blotting, siRNA...
Microcephalin (MCPH1/BRIT1) is a large nuclear protein that involved in the early cellular response to DNA damage, expression of which reduced variety types human tumors. A recent study by our group demonstrated MCPH1 markedly decreased lung cancer. However, it remains unclear whether inducing may ameliorate cancer, and, if so, mechanisms underlie this process. The results present was downregulated cancer tissues compared with normal tissues. Furthermore, overexpression A549 non-small cell...
Abstract Background Endometrial dysfunction is closely correlated with the development of multiple severe gynecological disorders including intrauterine adhesion. Accumulating evidence supports that some long non‐coding RNAs (lncRNAs) have peptide‐coding potential. In this text, ability lncRNA SNHG6 was examined. Also, effects an SNHG6‐encoded peptide on viability and migration human endometrial stromal cells (hESCs) epithelial (hEECs) related molecular mechanisms were explored. Methods The...
Cervical cancer is a common malignant tumor in females. Orthodenticle homolog 1 (OTX1) serves key role the occurrence and progression of tumors. The present study aimed to investigate potential mechanism OTX1 cervical cancer. expression was analyzed by western blotting, reverse transcription‑quantitative PCR immunohistochemistry. MTT assay performed assess cell viability. EdU colony formation were used measure proliferation. Wound healing Transwell assays migration invasion. Western blot for...
Toxicarioside G (TCG), a natural product isolated from Calotropis gigantea, has been found to exhibit potent anticancer effects. The present study aimed investigate the effect of TCG on SW480 colorectal cancer cell line and role autophagy Yes1 associated transcriptional regulator (YAP) in TCG‑mediated inhibition proliferation viability. Cell was detected using MTT, BrdU, colony formation LDH release assays, while apoptosis analyzed flow cytometry western blot analyses. Immunofluorescence...
The functions and molecular mechanisms of SPI1-related protein (SPIB) were examined in cervical cancer (CC) cells.Genes related to miscarriage prognosis CC identified by Kaplan-Meier differential expression analysis, respectively. Cell proliferation, apoptosis, migration, invasion cell counting kit-8, flow cytometry, transwell assays, potential SPIB speculated gene set enrichment analysis (GSEA) analysis. mRNA levels genes RT-qPCR western blot effect on macrophage cells was tested...
<title>Abstract</title> Cervical cancer is a serious health issue affecting women. Cancer development the result of co-evolution between tumor cells and stroma microenvironment, Associated Fibroblasts (CAFs) significant part plays big role in helping grow, spread, become aggressive. To investigate biological function CAFs progression cervical cancer, we developed novel CAFs-integrated tumoroid model that can mimic microenvironment. Our cultured organoids successfully reproduced key features...