A5061883915- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- Autism Spectrum Disorder Research
- Cerebral Palsy and Movement Disorders
- Histone Deacetylase Inhibitors Research
- Tryptophan and brain disorders
- Ubiquitin and proteasome pathways
- Family and Disability Support Research
- Neuroendocrine regulation and behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Resilience and Mental Health
University at Buffalo, State University of New York
2021-2024
Exposure to prolonged stress in critical developmental periods induces heightened vulnerability psychiatric disorders, which may have sex-specific consequences. Here we investigate the neuronal circuits mediating behavioral changes mice after chronic adolescent social isolation stress. Escalated aggression is exhibited stressed males, while withdrawal shown females. In vivo multichannel recordings of free-moving animals indicate that pyramidal neurons prefrontal cortex (PFC) from males...
ADNP and POGZ are two top-ranking risk factors for autism spectrum disorder intellectual disability, but how they linked to these neurodevelopmental disorders is largely unknown. Both chromatin regulators, which could profoundly affect gene transcription cellular function in the brain. Using post-mortem tissue from patients with disorder, we found diminished expression of prefrontal cortex, a region highly implicated disorders. To understand functional role factors, used viral-based transfer...
Autism spectrum disorder (ASD) is a lifelong developmental characterized by social deficits and other behavioral abnormalities. Dysregulation of epigenetic processes, such as histone modifications chromatin remodeling, have been implicated in ASD pathology, provides promising therapeutic target for ASD. Haploinsufficiency the SHANK3 gene causally linked to ASD, so adult (3-5 months old) Shank3-deficient male mice were used this drug discovery study. We found that combined administration...