A5054644961- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Epigenetics and DNA Methylation
- Genomic variations and chromosomal abnormalities
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Congenital heart defects research
- Ion channel regulation and function
- Social Media in Health Education
- Death Anxiety and Social Exclusion
- Neuroblastoma Research and Treatments
- Neural dynamics and brain function
- Misinformation and Its Impacts
- Neurotransmitter Receptor Influence on Behavior
- Climate Change Communication and Perception
- Ubiquitin and proteasome pathways
- Quantum optics and atomic interactions
- Online Learning and Analytics
- Memory and Neural Mechanisms
- Psychedelics and Drug Studies
- Genetic Neurodegenerative Diseases
- Histone Deacetylase Inhibitors Research
- Digital Mental Health Interventions
- Neuroinflammation and Neurodegeneration Mechanisms
- Media Influence and Health
Stanford University
2022-2024
Mind Science Foundation
2024
University at Buffalo, State University of New York
2018-2022
Jacobs (United States)
2021
West Virginia University
2018
MDMA (3,4-methylenedioxymethamphetamine) is a psychoactive drug with powerful prosocial effects. While sometimes termed an "empathogen," empirical studies have struggled to clearly demonstrate these effects or pinpoint underlying mechanisms. Here, we paired the social transfer of pain and analgesia-behavioral tests modeling empathy in mice-with region-specific neuropharmacology, optogenetics, transgenic manipulations explore MDMA's action as empathogen. We report that MDMA, given...
Microdeletion of the human 16p11.2 gene locus has been linked to autism spectrum disorder (ASD) and intellectual disability confers risk for a number other neurodevelopmental deficits. Transgenic mice carrying deletion (<i>16p11</i><sup>+/−</sup>) display phenotypes reminiscent those in patients with syndrome, but molecular mechanisms treatment strategies these remain unknown. In this study, we have found that both male female <i>16p11</i><sup>+/−</sup> exhibit deficient NMDA receptor...
Training programs exist that prepare college students, faculty, and staff to identify support students potentially at risk for suicide. Kognito is an online program trains users through simulated interactions with virtual humans. This study evaluated Kognito's effectiveness in preparing intervene at-risk students.Training was completed by 2,727 university from April, 2014 September, 2015.Voluntary mandatory participants a land-grant modules designed higher education, along pre-...
ADNP and POGZ are two top-ranking risk factors for autism spectrum disorder intellectual disability, but how they linked to these neurodevelopmental disorders is largely unknown. Both chromatin regulators, which could profoundly affect gene transcription cellular function in the brain. Using post-mortem tissue from patients with disorder, we found diminished expression of prefrontal cortex, a region highly implicated disorders. To understand functional role factors, used viral-based transfer...
Autism spectrum disorder (ASD) is a lifelong developmental characterized by social deficits and other behavioral abnormalities. Dysregulation of epigenetic processes, such as histone modifications chromatin remodeling, have been implicated in ASD pathology, provides promising therapeutic target for ASD. Haploinsufficiency the SHANK3 gene causally linked to ASD, so adult (3-5 months old) Shank3-deficient male mice were used this drug discovery study. We found that combined administration...
NMDARs are ionotropic glutamate receptors widely expressed in the CNS, where they mediate phenomena as diverse neurotransmission, information processing, synaptogenesis, and cellular toxicity. They function glutamate-gated Ca<sup>2+</sup>-permeable channels, which require glycine coagonist, can be modulated by many diffusible ligands cues, including mechanical stimuli. Previously, we found that, cultured astrocytes, shear stress initiates NMDAR-mediated Ca<sup>2+</sup> entry absence of added...
N-terminal methylation is an important posttranslational modification that regulates protein/DNA interactions and plays a role in many cellular processes, including DNA damage repair, mitosis, transcriptional regulation. Our generation of constitutive knockout mouse for the methyltransferase NRMT1 demonstrated its loss results severe developmental abnormalities premature aging phenotypes. As often accompanied by neurodegeneration, we more specifically examined how affects neural pathology...
Microdeletion of the human 16p11.2 gene locus confers risk for autism spectrum disorders and intellectual disability. How deletion is linked to these neurodevelopmental whether there are treatment avenues manifested phenotypes remain be elucidated. Emerging evidence suggests that epigenetic aberrations strongly implicated in autism.
One of the core symptoms autism spectrum disorder (ASD) is impaired social interaction. Currently, no pharmacotherapies exist for this symptom due to complex biological underpinnings and distinct genetic models which fail represent broad disease spectrum. convincing hypothesis explaining deficits in human ASD patients amotivation, however it unknown whether mouse condition. Here we used two highly trusted (male Shank3-deficient [Shank3+/ΔC ] mice modeling monogenic etiology ASD, inbred BTBR...
We provide protocols for the social transfer of pain and analgesia in mice. describe steps to induce or (pain relief) bystander mice with a 1-h interaction partner injected CFA (complete Freund's adjuvant) morphine, respectively. detail behavioral tests assess untreated This protocol has been validated rats can be used investigating mechanisms empathy. For complete details on use execution this protocol, please refer Smith et al. (2021).
Abstract N-terminal methylation is an important post-translational modification that regulates protein/DNA interactions and plays a role in many cellular processes, including DNA damage repair, mitosis, transcriptional regulation. Our generation of constitutive knockout mouse for the methyltransferase NRMT1, demonstrated its loss results severe developmental abnormalities premature aging. As aging often accompanied by neurodegeneration, we more specifically examined how NRMT1 affects neural...
Abstract N-Methyl-D-aspartic (NMDA) receptors are excitatory glutamate-gated ion channels. Their activation is essential for the normal development, maintenance, and plasticity of synapses in central nervous system. They function as Ca 2+ -permeable channels, require glycine co-agonist, can be modulated by myriad diffusible ligands cellular cues, including mechanical stimuli. Previously, we found that cultured astrocytes, shear stress initiates NMDA receptor-mediated entry absence added...