A5008685938- Neuroscience and Neuropharmacology Research
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Aluminum Alloy Microstructure Properties
- Aluminum Alloys Composites Properties
- Neural dynamics and brain function
- High Entropy Alloys Studies
- Nicotinic Acetylcholine Receptors Study
- High-Temperature Coating Behaviors
- Additive Manufacturing Materials and Processes
- Memory and Neural Mechanisms
- Advanced materials and composites
- Advanced ceramic materials synthesis
- Catalytic Processes in Materials Science
- Photoreceptor and optogenetics research
- Mesoporous Materials and Catalysis
- Microbial Community Ecology and Physiology
- Central Venous Catheters and Hemodialysis
- Geothermal Energy Systems and Applications
- Molecular Sensors and Ion Detection
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neural Engineering
- Titanium Alloys Microstructure and Properties
- Vascular anomalies and interventions
- Treatment of Major Depression
University at Buffalo, State University of New York
2015-2024
Universitatea Națională de Știință și Tehnologie Politehnica București
2007-2024
Jacobs Institute
2023-2024
Universitatea Din Petrosani
2024
Buffalo State University
2014-2023
Jacobs (United States)
2020-2023
Victor Babeș University of Medicine and Pharmacy Timișoara
2022
University of Life Sciences in Lublin
2022
Univesity of Life Science "King Mihai I" from Timisoara
2022
University of Bucharest
1992-2017
The NMDA-type glutamate receptor (NMDAR) is essential for synaptogenesis, synaptic plasticity, and higher cognitive function. Emerging evidence indicates that NMDAR Ca 2+ permeability under the control of cAMP/protein kinase A (PKA) signaling. Whereas functional impact PKA on NMDAR-dependent signaling well established, molecular target remains unknown. Here we identify serine residue 1166 (Ser1166) in carboxy-terminal tail subunit GluN2B to be a direct phosphorylation critical permeation...
Abstract While studying the physiological response of primary rat astrocytes to fluid shear stress in a model traumatic brain injury (TBI), we found that induced Ca 2+ entry. The influx was inhibited by MK-801, specific pore blocker N-Methyl-D-aspartic acid receptor (NMDAR) channels, and this occurred absence agonists. Other NMDA open channel blockers ketamine memantine showed similar effect. competitive glutamate antagonists AP5 GluN2B-selective inhibitor ifenprodil reduced NMDA-activated...
N-methyl-d-aspartate (NMDA) receptors are the only neurotransmitter whose activation requires two distinct agonists. Heterotetramers of GluN1 and GluN2 subunits, NMDA broadly distributed in central nervous system, where they mediate excitatory currents response to synaptic glutamate release. Pore opening depends on concurrent presence glycine, which modulates amplitude time course glutamate-elicited response. Gating schemes for fully glutamate- glycine-bound have been described sufficient...
The paper considers a new concept of alloy with high entropy (HEA) for biomedical applications. HEAs are different from the conventional metallic materials by more than five alloying elements, in proportions between 5% and 35% at., which may form simple solid solutions BCC and/or FCC phases instead complicated intermetallic ones. These specific features provide HEA excellent mechanical properties (hardness, strength, malleability), oxidation corrosion resistance, potential applications...
A retinol dehydrogenase, RoDH(I), which recognizes holo-cellular retinol-binding protein (CRBP) as substrate, has been cloned, expressed, and identified a short-chain dehydrogenase/reductase (Chai, X., Boerman, M. H. E. M., Zhai, Y., Napoli, J. L.(1995) <i>J. Biol. Chem.</i> 270, 3900-3904). This work reports the cloning expression of cDNA encoding RoDH isozyme, RoDH(II). The predicted amino acid sequence verifies RoDH(II) dehydrogenase/reductase, 82% identical with RoDH(I). recognized...
Neurosteroids are potent neuromodulators which act in part by binding to and modifying the activity of neurotransmitter-gated channels. Pregnanolone sulfate (PAS) is an endogenous neurosteroid that inhibits NMDA receptors neuroprotective vivo . To delineate mechanism receptor inhibition pregnanolone we used kinetic analyses equilibrium single-channel currents recorded from individual GluN1/GluN2A receptors. Results show PAS (0.1 m ) reduces open probability 50% solely increasing ∼5-fold mean...
NMDA receptors mediate excitatory neurotransmission in brain and spinal cord play a pivotal role the neurological disease state of chronic pain, which is caused by central sensitization. Bupivacaine indicated local anesthetic caudal, epidural, anesthesia widely used clinically to manage acute pain. In addition blocking Na + channels, bupivacaine affects activity many other including receptors. Importantly, inhibits receptor-mediated synaptic transmission dorsal horn cord, an area critically...
The integrative nuclear FGFR1 signaling (INFS) pathway functions in association with cellular growth, differentiation, and regulation of gene expression, is activated by diverse extracellular signals. Here we show that stimulation angiotensin II (AII) receptors, depolarization, or activation protein kinase C (PKC) adenylate cyclase all lead to accumulation fibroblast growth factor 2 (FGF-2) FGFR1, splicing factor-rich domains, the tyrosine hydroxylase (TH) promoter bovine adrenal medullary...