A5101547488- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Stress Responses and Cortisol
- Neural dynamics and brain function
- Pharmacological Effects and Toxicity Studies
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Acute Ischemic Stroke Management
- EEG and Brain-Computer Interfaces
- Mitochondrial Function and Pathology
- Neuroendocrine regulation and behavior
- Cerebrovascular and Carotid Artery Diseases
- Neuroscience and Neural Engineering
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Anesthesia and Neurotoxicity Research
- Genetic Neurodegenerative Diseases
- Genetics and Neurodevelopmental Disorders
- Trace Elements in Health
- Heart Rate Variability and Autonomic Control
- Neurological Disease Mechanisms and Treatments
- Craniofacial Disorders and Treatments
- Heavy Metal Exposure and Toxicity
- Cleft Lip and Palate Research
- Pregnancy and preeclampsia studies
Shanxi Medical University
2008-2024
Shanxi Academy of Medical Sciences
2020-2024
Huazhong University of Science and Technology
2022-2024
Tongji Hospital
2022-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2020-2023
Chongqing Medical University
2020-2023
Peking University
2020-2022
National Health and Family Planning Commission
2020-2022
Taian City Central Hospital
2019-2021
University at Buffalo, State University of New York
2011-2018
Emerging evidence suggests that metabotropic glutamate receptors (mGluRs) are potential novel targets for brain disorders associated with the dysfunction of prefrontal cortex (PFC), a region critical cognitive and emotional processes. Because N-methyl-d-aspartic acid receptor (NMDAR) dysregulation has been strongly pathophysiology mental illnesses, we examined possibility mGluRs might be involved in modulating PFC functions by targeting postsynaptic NMDARs. We found application prototypical...
Rare earth elements (REEs) are ubiquitous in the environment. Animal experiments have shown that many REEs adverse impacts on health of fetuses. However, data from humans scarce. In this study, we examined associations between concentrations 10 maternal serum and risk for fetal neural tube defects (NTDs). The study included 200 pregnant women with pregnancies affected by NTDs 400 healthy fetuses/infants. Fifteen were assessed; them detectable over 60% samples statistical analyses, including...
Corticosteroid stress hormones exert a profound impact on cognitive and emotional processes. Understanding the neuronal circuits that are altered by chronic is important for counteracting detrimental effects of in brain region- cell type-specific manner. Using chemogenetic tool, Designer Receptors Exclusively Activated Drugs (DREADDs), which enables remote, noninvasive long-lasting modulation cellular activity signal transduction discrete populations vivo, we sought to identify specific...
This study examined the associations between concentrations of cobalt (Co), iron (Fe), manganese (Mn), molybdenum (Mo), selenium (Se), and zinc (Zn) in placental tissue risks for NTDs with a case-control design consisting 408 fetuses or newborns neural tube defects (NTDs) 593 non-malformed newborns. The Zn Fe were determined by inductively coupled plasma-emission spectrometer other four elements plasma-mass spectrometer. Element presented ng/g µg/g dry weight tissue. levels each six ETEs...
Emerging evidence from studies of Huntington disease (HD) pathophysiology suggests that huntingtin (htt) and its associated protein HAP1 participate in intracellular trafficking synaptic function. However, it is largely unknown whether AMPA receptor trafficking, which crucial for controlling the efficacy excitation, affected by mutant with polyglutamine expansion (polyQ-htt). In this study, we found expressing polyQ-htt neuronal cultures significantly decreased amplitude frequency...
The prefrontal cortex (PFC), a region responsible for high-order cognitive functions, such as decision-making, attention and working memory, is highly influenced by stress corticosteroid hormones. Recently it has been shown that acute affects PFC functions potentiating glutamatergic transmission via mechanism dependent on glucocorticoid receptor (GR) its downstream target, serum glucocorticoid-inducible kinase (SGK). To identify the key regulators of responses, we examined role histone...
<i>N</i>-Methyl-d-aspartate (NMDA) receptor (NMDAR) hypofunction has been postulated to contribute the cognitive deficit of schizophrenia. In this study, we examined effect lurasidone (Latuda; Dainippon Sumitomo Pharma Co. Ltd., Tokyo, Japan), a newly approved atypical antipsychotic drug (APD), on NMDAR synaptic function in rat frontal cortical pyramidal neurons. vivo administration produced significant and selective enhancement NMDAR-mediated responses surface expression NR2A NR2B subunits....
Abstract Aberrantly synchronized neuronal discharges in the brain lead to epilepsy, a devastating neurological disease whose pathogenesis and mechanism are unclear. SAPAP3, cytoskeletal protein expressed at high levels postsynaptic density (PSD) of excitatory synapses, has been well studied striatum, but role SAPAP3 epilepsy remains elusive. In this study, we sought investigate molecular, cellular, electrophysiological behavioral consequences perturbations mouse hippocampus. We identified...
The prefrontal cortex (PFC), a key brain region for cognitive and emotional processes, is highly regulated by dopaminergic inputs. dopamine D4 receptor, which enriched in PFC, has been implicated mental disorders, such as attention deficit-hyperactivity disorder schizophrenia. Recently we have found homeostatic regulation of AMPA receptor-mediated synaptic transmission PFC pyramidal neurons the providing potential mechanism stabilizing cortical excitability. Because stress tightly linked to...
The novel neuroprotective action of Humanin (HN), especially its derivative [Gly(14)]-humanin (HNG), against Alzheimer's disease (AD)-related insults has been reported. However, it is still short electrophysiological evidence for the protection HN on synaptic plasticity, and molecular mechanisms that underlie function remain largely unknown. present study examined effects intracerebroventricular (i.c.v.) injection HNG amyloid beta (Abeta), a main constituent senile plaques in AD brain,...
To explore the epidemiological characteristics of patients with lymphoepithelial carcinoma (LEC) head and neck prognostic factors.We conducted a retrospective cohort study cases LEC retrieved from Surveillance, Epidemiology End Results database. Kaplan-Meier survival analysis log-rank test were employed to assess overall (OS) cancer-specific (CSS). Univariate multivariate analyses used construct Cox regression models. We established nomograms predict OS CSS among nasopharyngeal LEC, who...
In this study, the spike discharges of one subtype bullfrog retinal ganglion cells (dimming detectors) in response to repetitive full field light-OFF stimuli were recorded using multi-electrode arrays. Two different types concerted activity (precise synchronization and correlated activity) could be distinguished. The nearby with overlapped receptive areas often fired synchrony, whereas was mainly observed from remote cell pairs separated fields. After bicuculline application, strength...