A5036423556- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Cancer Immunotherapy and Biomarkers
- Pregnancy and Medication Impact
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Cellular transport and secretion
- Drug Transport and Resistance Mechanisms
- Epilepsy research and treatment
- Autoimmune Neurological Disorders and Treatments
- Gastrointestinal Tumor Research and Treatment
- Trace Elements in Health
- Iron Metabolism and Disorders
- HER2/EGFR in Cancer Research
- Neonatal and fetal brain pathology
- Vascular Malformations Diagnosis and Treatment
- Pharmacological Effects and Toxicity Studies
- Ocular Diseases and Behçet’s Syndrome
- Atherosclerosis and Cardiovascular Diseases
Tianjin Chest Hospital
2018-2024
Tianjin University
2024
Yantai Academy of Agricultural Sciences
2024
Chongqing Medical University
2019-2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2019-2022
First Affiliated Hospital of Xi'an Jiaotong University
2011-2021
Hunan Agricultural University
2021
Jining First People's Hospital
2018
Peking Union Medical College Hospital
2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2017
Acanthopanax senticosus (AS) is a well-known, highly effective traditional Chinese herbal medicine. Polysaccharides extracted from AS (ASPS) have multiple pharmacologic and biological activities with potential use as additives in broiler chicken feed. This trial evaluated the effects of dietary ASPS on growth performance, immune function, antioxidation, ileal microbial populations chickens. A total 240 1-day-old Arbor Acres male chicks were randomly divided into 4 groups, 10 replicates 6 fed...
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of the subtilisin family PCs that encodes neural apoptosis-regulated 1. However, precise role PCSK9 in lung cancer cell apoptosis has remained elusive. In present study, A549 human adenocarcinoma cells were transfected with small interfering (si)RNA to investigate underlying mechanisms apoptosis. The results indicated siRNA exhibited anti-tumor activity by inducing as determined Cell Counting Kit-8 and Hoechst staining...
Background Bread wheat is one of the most important food crops associated with ensuring security and human nutritional health. The starch quality an index high-quality wheat. It affected by a complex series factors; among which, suitable sowing time key factor. Aim methods To analyze integrative effects on wheat, in present study, we selected bread cultivar Jinan 17 investigated effect different times properties related genes analyzing X-ray diffraction patterns, apparent amylose content,...
Purpose Continuous development of digital technology makes it necessary for entrepreneurs to pivot cope with the environmental changes. However, limited research has focused on important strategic orientation new ventures in contexts, orientation, which depicts tendency utilize technologies create value. This aims explore relationship between and pivoting, along mediating role dynamic capabilities as essential organizational competencies. Additionally, study investigates influence boundary...
Abstract Macrophage‐mediated regulation of chondrocytes plays an important role in promoting temporomandibular joint (TMJ) inflammation. We investigated whether extracellular vesicles (EVs) derived from M1 macrophages (M1‐EVs) have a proinflammatory effect on TMJ inflammation and what the associated mechanisms are. In vitro , purified THP‐1 cell–derived M1‐EVs were applied to human condylar chondrocytes, vivo bone marrow–derived (BMDMs) injected into rat TMJs. The levels IL‐6, IL‐8, IL‐1β,...
The FAT atypical cadherin 1/2/3/4 (FAT1/2/3/4) has been linked to the occurrence and development of various cancers. However, prognostic immunological role FAT1/2/3/4 in non-small cell lung cancer (NSCLC) not clarified.The association mutations with tumor mutation burden (TMB), immunity microenvironment, response ICIs NSCLC was investigated. Whole-exome sequencing data adenocarcinoma (LUAD), squamous carcinoma (LUSC) samples from Cancer Genome Atlas (TCGA), an immunotherapy set comprising...
Abstract Background Neoadjuvant immune checkpoint inhibitors(ICIs) combined with chemotherapy can improve non-small cell lung cancer(NSCLC) patients' pathological responses and show promising improvements in survival. Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disease, its associated abnormal response affects not only the immunotherapy efficacy but also immune-related adverse events. It remains unclear whether NSCLC patients COPD benefit from neoadjuvant ICIs...
The first-line standard treatment option for patients with NSCLC complicated Chronic obstructive pulmonary disease (COPD) is still unclear and relies on the of alone. To date, a limited number retrospective studies have explored efficacy safety immunotherapy in COPD. We therefore designed this study to further explore
Abstract Aberrantly synchronized neuronal discharges in the brain lead to epilepsy, a devastating neurological disease whose pathogenesis and mechanism are unclear. SAPAP3, cytoskeletal protein expressed at high levels postsynaptic density (PSD) of excitatory synapses, has been well studied striatum, but role SAPAP3 epilepsy remains elusive. In this study, we sought investigate molecular, cellular, electrophysiological behavioral consequences perturbations mouse hippocampus. We identified...
Salidroside (SAL) is the major pharmacologically active constituent of Rhodiola rosea, which possesses a wide range pharmacological functions, including anti‑aging, anti‑inflammatory, antioxidant, anticancer and neuroprotective activities. However, effects mechanisms SAL on oxidative stress in retinal pigment epithelial (RPE) cells exposed to hydrogen peroxide (H2O2) remain unclear. The present study investigated protective underlying against H2O2‑induced human RPE cells. ARPE‑19 were...
BackgroundAlthough increased expression of hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein (HIP/PAP) has been reported in ulcerative colitis (UC), its role UC remains unclear. This study was designed to assess the function HIP/PAP experimental and further explore underlying mechanisms.
Lung cancer, a malignant tumor, is the most frequently fatal with poor survival rates in advanced stages. In order to improve understanding of this disease, and outcomes patients, additional studies are required. present study, differentially expressed genes (DEGs) patients lung cancer compared controls were identified. To understand how these DEGs act together account for initiation protein interaction network transcriptional regulatory constructed explore clusters pathways results...
An increasing body of evidence has demonstrated that microRNA (miR) deregulation serves pivotal roles in tumor progression and metastasis. However, the function miR‑379 lung cancer remains understudied, particularly non‑small cell (NSCLC). Bioinformatics luciferase reporter analyses confirmed conserved helix‑loop‑helix ubiquitous kinase (CHUK) is a target miR‑379, which may directly bind to 3'‑untranslated region CHUK significantly downregulate its expression NSCLC cells. Transwell assays...
Hepatocellular carcinoma (HCC) is the third most common malignant tumor of digestive system. Plasma cell heterotopic gene 1 (PVT1) an intergenic long non-coding RNA that aberrantly expressed in different cancers. Myocardin related transcription factor A (MKL1) a transcriptional coactivator serum response has been shown to promote cancer migration and invasion. In this study, we investigated relationship between PVT1 MKL1 as novel regulatory mechanism underlying HCC progression. We used HepG2...
To detect the mutations in two candidate genes, myocilin (MYOC) and cytochrome P450 1B1 (CYP1B1), a Chinese family with primary open angle glaucoma (POAG).The was composed of three members, parents daughter. All members underwent complete ophthalmologic examinations. Exons MYOC CYP1B1 genes were screened for sequence alterations by polymerase chain reaction (PCR) direct DNA sequencing.The mother proband, she diagnosed as POAG both eyes. Her daughter juvenile-onset POAG. The father...
Chronic obstructive pulmonary disease (COPD) is an inflammatory-related highly associated with increased lung cancer risk. Studies have explored the tumor promoting roles for zinc finger protein 143 (ZNF143). However, role of ZNF143 in COPD and microenvironment non-small cell (NSCLC) has not been fully elucidated.COPD-related key genes were identified by differential gene expression evaluation, WGCNA SVM-RFE analysis using mRNA data retrieved from public databases. ROC was conducted to...
This study aimed to characterize the clinical features of a Chinese pedigree with neurofibromatosis type 1 (NF1) and identify mutations in NF1 gene.In this three-generation family containing 8 members, 5 had been diagnosed others were asymptomatic.All members underwent complete medical examinations.Molecular genetic analyses performed on all subjects included study.All exons amplified by polymerase chain reaction, sequenced, compared reference database.Possible changes function protein...