A5103217768- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tissue Engineering and Regenerative Medicine
- Electrochemical sensors and biosensors
- Advanced biosensing and bioanalysis techniques
- Neonatal Respiratory Health Research
- Mesenchymal stem cell research
- Digital Games and Media
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Social Media and Politics
- SARS-CoV-2 and COVID-19 Research
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Nerve injury and regeneration
- PI3K/AKT/mTOR signaling in cancer
- Renal and related cancers
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
- Ginseng Biological Effects and Applications
- Genomics, phytochemicals, and oxidative stress
- Misinformation and Its Impacts
- Cancer, Hypoxia, and Metabolism
- Chromatography in Natural Products
- COVID-19 Clinical Research Studies
- Pluripotent Stem Cells Research
Western University
2023-2024
Tianjin Chest Hospital
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
China-Japan Friendship Hospital
2020-2024
Nanfang Hospital
2024
Tianjin University
2024
Southern Medical University
2024
First Bethune Hospital of Jilin University
2024
Harbin Medical University
2021-2024
Nankai University
2018-2022
Rationale: Autophagy in Schwann cells (SCs) is crucial for myelin debris degradation and clearance following peripheral nerve injury (PNI). Nerve growth factor (NGF) plays an important role reconstructing fibers promoting axonal regeneration. However, it remains unclear if NGF effect enhancing regeneration mediated through autophagic of SCs. Methods: In vivo, free solution plus with/without pharmacological inhibitors were administered to a rat sciatic crush model. vitro, the primary its cell...
Abstract Lung injury and fibrosis represent the most significant outcomes of severe acute lung disorders, including COVID-19. However, there are still no effective drugs to treat fibrosis. In this study, we report generation clinical-grade human embryonic stem cells (hESCs)-derived immunity- matrix-regulatory (IMRCs) produced under good manufacturing practice requirements, that can in vivo. We generate IMRCs by sequentially differentiating hESCs with serum-free reagents. possess a unique...
Abstract ICTs are pivotal in the existing social order and especially during COVID‐19 global pandemic. This panel focuses on use of by different actors, including individuals, nonprofit organizations, governments around globe responding to this COVID crisis. We tackle three essential questions about First, what role do play a crisis? Second, how affect when tensions between control, autonomy, power shift? Third, theoretical practical implications ICT health Each panelists will discuss their...
Abstract Acute lung injury (ALI) is an important pathological process of acute respiratory distress syndrome, yet there are limited therapies for its treatment. Mesenchymal stem cells-derived exosomes (MSCs-Exo) have been shown to be effective in suppressing inflammation. However, the effects MSCs-Exo on ALI and underlying mechanisms not well elucidated. Our data showed that MSCs-Exo, but derived from MRC-5 cells (MRC-5-Exo), which human fetal fibroblast cells, significantly improved chest...
Improving the lithium storage properties of a Si negative electrode is great significance for ion batteries. A major challenge to fabricate Si-based active materials with good electronic conduction and structural integrity in process discharging charging. In this study, nanoparticles are covalently bound surface graphene sheets via aromatic linkers through diazonium chemistry. The resulting Si–Ph–G nanocomposite delivers delithiation capacity 1079 828 mAh g−1 initial 50th cycle at current...
This article bringings greater conceptual clarity to research on trolling, with a study that maps college students' perceptions of trolling behaviors and compares them the media scholarly interpretations. It identifies 4 behavioral types – serious (not funny ideologically motivated), humorous non-trolling behaviors, 7 dimensions meaningfulness, representativeness, pseudo-sincerity, intentionality, provocativeness, repetition, satire. Employing Formal Concept Analysis it charts relationships...
The process of axonal regeneration after peripheral nerve injury (PNI) is slow and mostly incomplete. Previous studies have investigated the neuroprotective effects fibroblast growth factor 10 (FGF10) against spinal cord cerebral ischemia brain injury. However, role FGF10 in remains unknown. In this study, we aimed to investigate underlying therapeutic on functional recovery PNI explore associated mechanism. Our results showed that administration promoted damage. Moreover, exogenous...
Trolling behaviors are extremely diverse, varying \ by context, tactics, motivations, and impact. Definitions, perceptions of, reactions to online trolling vary. Since not all is equal or deviant, managing these requires context sensitive strategies. This paper describes appropriate responses various acts of in based on college students North America. In addition strategies for dealing with deviant trolling, this illustrates the complexity socially politically motivated trolling.
It is unknown whether antibody-mediated enhancement (ADE) contributes to the pathogenesis of COVID-19, and conditions for ADE needs be elucidated. We demonstrated that without inducing an ACE2-independent on Raji cells, neutralizing antibody CB6, a mouse anti-S1 serum convalescent plasma, induced cells expressing FcγRIIA/CD32A low levels endogenous ACE2. occurred at sub-neutralizing concentrations, indicating unneutralized S protein was required ADE. The enhanced infectivity 614G variant...
Online trolling has become increasingly prevalent and visible in online communities. Perceptions of reactions to behaviors varies significantly from one community another, as are contextual vary across platforms Through an examination seven scenarios, this article intends answer the following questions: how do differ contexts; perceptions case case; what aspects context perceived be important by public? Based on focus groups interview data, we discuss ways which norms demographics,...
Anthocyanins have been shown to exhibit antitumor activity in several cancers<italic>in vitro</italic>and<italic>in vivo</italic>.
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Whether extracellular vesicles are effective in treating IPF what the optimal administrative route not clear. Our previous studies have shown that immunity matrix regulatory cells (IMRCs) derived from human embryonic stem can safely treat injury mouse models, its mechanism of action related to paracrine effect. In this study, we investigated therapeutic effects IMRC-derived (IMRC-EVs) on...
Glycyrrhetinic acid (GA), a bioactive component in the human diet, has been reported to improve hyperglycemia, dyslipidemia, insulin resistance and obesity rats with metabolic syndrome. However, GA-specific target proteins mechanisms involved downstream signaling cross-talk sensitivity have not fully elucidated. In this study, potential targets of GA were identified by chemical proteomics strategies using serial probes for fishing cell molecular imaging. Intracellular enzyme activity...
Human alveolar type II (AT II) epithelial cells are valuable for the cellular therapy of lung disease. induced pluripotent stem (iPSCs) have ability to generate AT that can be used in modeling and treatment disease caused by dysfunction cells. In this study, we present a simple, effective, noninvasive way obtaining human iPSCs from exfoliated renal cells, which exist urine. Alkaline phosphatase (AP) staining, immunofluorescence karyotyping, teratoma experiments proved these pluripotent....
Contributing to research on social activism as a form of collective action, we report Diba, sizable group Chinese nationalists, who overcame the Great Firewall in order troll Taiwan's political leadership. Diba's can be characterized negotiating tension between two seemingly opposed goals. On one hand is their construction pro-PRC message using tactics Internet subcultures (memes, trolling, etc.), but toned down meet standards civility. other hand, by collectively breaching and establishing...
Abstract Background Neoadjuvant immune checkpoint inhibitors(ICIs) combined with chemotherapy can improve non-small cell lung cancer(NSCLC) patients' pathological responses and show promising improvements in survival. Chronic obstructive pulmonary disease (COPD) is a systemic inflammatory disease, its associated abnormal response affects not only the immunotherapy efficacy but also immune-related adverse events. It remains unclear whether NSCLC patients COPD benefit from neoadjuvant ICIs...
Members of the RAS proto-oncogene superfamily are indispensable molecular switches that play critical roles in cell proliferation, differentiation, and survival. Recent studies have attempted to prevent interaction RAS/GTP with guanine nucleotide exchange factors (GEFs), impair RAS-effector interactions, suppress localization oncogenic signalling. The present study aimed investigate effect natural triterpenoic acid inhibitor glycyrrhetinic acid, which is isolated from roots Glycyrrhiza plant...