A5083957731- Extracellular vesicles in disease
- Phagocytosis and Immune Regulation
- PI3K/AKT/mTOR signaling in cancer
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Endoplasmic Reticulum Stress and Disease
- Healthcare and Venom Research
- Galectins and Cancer Biology
- Cell Adhesion Molecules Research
Southern Medical University
2021-2024
Nanfang Hospital
2021-2024
Third Affiliated Hospital of Southern Medical University
2013
Abstract Trastuzumab resistance negatively influences the clinical efficacy of therapy for human epidermal growth factor receptor 2 (HER2) positive gastric cancer (GC), and underlying mechanisms remain elusive. Exploring finding effective approaches to address trastuzumab are great necessity. Here, we confirmed that endoplasmic reticulum (ER) stress-induced by up-regulating miR-301a-3p in HER2-positive GC cells. Moreover, elucidated mediated down-regulating expression leucine-rich repeats...
Objective To investigate the relationship between autophagy in spinal dorsal horn and development of morphine tolerance rats.Methods Twenty-four healthy male Sprague-Dawley rats,in which intrathecal (IT) catheters were successfully placed,were randomly divided into 3 groups (n =8 each):control group (group C),morphine M) + rapamycin as a reinforcing agent for MR).Morphine was induced with IT 20 μg twice day 7 consecutive days.While equal volume normal saline given C.In addition,rapamycin...