A5039653083- PI3K/AKT/mTOR signaling in cancer
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Treatments and Mutations
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Galectins and Cancer Biology
- Pancreatic and Hepatic Oncology Research
- Melanoma and MAPK Pathways
- Inflammatory Biomarkers in Disease Prognosis
- Extracellular vesicles in disease
- Adsorption and biosorption for pollutant removal
- Ear Surgery and Otitis Media
- Endoplasmic Reticulum Stress and Disease
- Cancer Cells and Metastasis
- Tendon Structure and Treatment
- Orthopedic Surgery and Rehabilitation
- RNA modifications and cancer
- Lung Cancer Research Studies
- Autophagy in Disease and Therapy
- Pancreatitis Pathology and Treatment
- Ginseng Biological Effects and Applications
- Cancer-related molecular mechanisms research
Hohai University
2025
Kunming Medical University
2025
First Affiliated Hospital of Kunming Medical University
2025
Peking University Third Hospital
2016-2024
Southern Medical University
2014-2024
Nanfang Hospital
2013-2024
Anhui University of Traditional Chinese Medicine
2021-2024
Peking University
2016-2024
Wuhan University of Technology
2024
Guangzhou University of Chinese Medicine
2023
Posttranscriptional modification of tumor-associated factors plays a pivotal role in breast cancer progression. However, the underlying mechanism remains unknown. M6A modifications cells are dynamic and reversible have been found to impact tumor initiation progression through various mechanisms. In this study, we explored regulatory cell proliferation metabolism m6A methylation Hippo pathway. METHODS: A combination MeRIP-seq, RNA-seq metabolomics-seq was utilized reveal map tissues cells. We...
Abstract Background XB130 has been reported to be expressed by various types of cells such as thyroid cancer and esophageal cells, it promotes the proliferation invasion cells. Our previous study demonstrated that is also in gastric (GC), its expression associated with prognosis, but role GC not well characterized. Methods In this study, we investigated influence on tumorigenesis metastasis vivo vitro using MTT assay, clonogenic BrdU incorporation 3D culture, immunohistochemistry...
Metastasis-associated in colon cancer-1 (MACC1) is a newly identified oncogene, and little known about its role gastric cancer (GC). Our study was performed to investigate whether MACC1 influences the prognosis of GC patients explore potential mechanisms involved. expression verified be higher tissues than adjacent nontumorous by Western blotting. A retrospective analysis 361 (Stages I-IV) revealed that associated with more advanced disease, frequent postoperative recurrence, metastases...
Trastuzumab, a humanized antibody targeting HER2, exhibits remarkable therapeutic efficacy against HER2-positive gastric cancer. However, recurrent resistance presents revolutionary claims. Warburg effect and AKT signaling pathway was involved in the to trastuzumab. Our previous studies have demonstrated that overexpression of metastasis associated with colon cancer 1 (MACC1) predicted poor prognosis GC promoted tumor cells proliferation invasion. In this study, we found MACC1 significantly...
Recent studies have demonstrated the prognostic value of C-reactive protein/albumin (CRP/Alb) ratio in cancer. However, role CRP/Alb advanced pancreatic cancer (PC) has not been examined. A retrospective study 233 patients with PC was conducted. We investigated relationship between ratio, clinicopathological variables, and overall survival (OS). The optimal cutoff point 0.54. higher significantly associated an elevated neutrophil-lymphocyte (NLR) (P < 0.001) modified Glasgow score (mGPS)...
Abstract Trastuzumab has been successfully employed for the treatment of Her-2-positive gastric cancer. However, there are problems with both primary and secondary resistance to trastuzumab. In this study, we human carcinoma cell line NCI-N87 high Her-2 expression create trastuzumab-resistant NCI-N87/TR cells by stepwise exposure increasing doses Western blotting Real-time PCR were conducted detect protein gene levels. Compared cells, P-IGF-1R P-AKT proteins was significantly increased in...
Abstract Trastuzumab resistance negatively influences the clinical efficacy of therapy for human epidermal growth factor receptor 2 (HER2) positive gastric cancer (GC), and underlying mechanisms remain elusive. Exploring finding effective approaches to address trastuzumab are great necessity. Here, we confirmed that endoplasmic reticulum (ER) stress-induced by up-regulating miR-301a-3p in HER2-positive GC cells. Moreover, elucidated mediated down-regulating expression leucine-rich repeats...
XB130 is a newly characterized adaptor protein that was reported to promote thyroid tumor growth, but its role in the progression of other kinds cancer such as gastric (GC) remains unknown. Accordingly, we investigated association between expression and prognosis GC patients. The subjects were 411 patients with stages I IV. examined surgical specimens GC. Kaplan-Meier analysis Cox proportional hazards model used assess prognostic significance for survival recurrence. Moreover, cells stably...
Abstract This study was designed to assess the impact of several molecular markers and clinicopathological characteristics on postoperative survival patients with hepatocellular carcinoma (HCC). Postoperative clinical data 64 HCC were retrospectively analyzed. K‐ras , PIK3CA BRAF gene mutations in surgically resected specimens detected by pyrosequencing. H‐ras XB130 protein expression examined immunohistochemistry. A Cox proportional hazards regression model used for univariate multivariate...
Aberrant HGF/Met signaling promotes tumor migration, invasion, and metastasis through both autocrine non‐autocrine mechanisms; however, the molecular downstream mechanisms by which induces are incompletely understood. We here report that Ezrin expression is stimulated HGF correlates with activated HGF/Met, indicating regulates of Ezrin. show activates transcription factor Sp1 MAPK pathway, can in turn directly bind to promoter gene regulate its transcription. Notably, knockdown shRNAs...
Reports of fungal infection after total knee arthroplasty are extremely rare. In most reports, the infecting organism is a Candida species. The present report describes case involving 73-year-old immunocompetent woman who underwent and presented one month later with signs prosthetic infection. She joint debridement fluid was sent for culture sensitivity testing. showed growth Trichosporon asahii. patient administered intravenous intra-articular injections amphotericin B, followed by...
Abstract Targeting mutant BRAF in patients with melanomas harboring this oncogene has been highly successful as a first-line treatment, but other mutations may affect its efficacy and alter the route of acquired resistance resulting recurrence poor prognosis. As an evolving strategy, melanoma treatment needs to be expanded include targets based on newly discovered emerging molecules pathways. We here show that PERK plays critical role inhibitor-acquired impaired PTEN. Inhibition by either...
Context Qingre Huoxue (QRHX) decoction, a traditional Chinese medicine, has been widely used to prevent and treat myocardial infarction (MI).Objective This study elucidates the possible mechanisms of QRHX in preventing or treating MI rat model.Materials methods The chemical constituents were identified by UPLC-MS. Sprague-Dawley rats randomly divided into Sham (normal saline), Model QRHX-L, QRHX-M QRHX-H group (n = 10 per group). decoction was administered gavage for 14 days (5, 20...
Anaplastic lymphoma kinase (ALK) is a validated molecular target in non-small-cell lung cancer (NSCLC). However, the clinical benefits of ALK inhibitors are almost universally limited by emergence drug resistance.We monitored plasma circulating tumor DNA (ctDNA) using captured-based ultra-deep sequencing analysis one patient with metastatic ALK-positive NSCLC who had received therapies including first-, second- and third-generation inhibitors. Functional vitro studies were further undertaken...
The present study aimed to investigate the predictive value of pretreatment fibrinogen (FIB) levels in patients with cancer who received immunotherapy as a second-line treatment. A total 61 stage III-IV were included. cut-off FIB for predicting overall survival (OS) was determined by receiver operating characteristic curve analysis. prognostic on progression-free (PFS) and OS univariate multivariate analyses. Based point 3.47 g/l, divided into low (<3.47 g/l) high (≥3.47 groups. level more...