A5039076461- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Computational Drug Discovery Methods
- Cancer Mechanisms and Therapy
- Biofuel production and bioconversion
- RNA modifications and cancer
- Melanoma and MAPK Pathways
- Bacterial Infections and Vaccines
- Microbial Metabolic Engineering and Bioproduction
- MicroRNA in disease regulation
- Spectroscopy Techniques in Biomedical and Chemical Research
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Gastrointestinal motility and disorders
- Pharmacological Effects of Natural Compounds
- PI3K/AKT/mTOR signaling in cancer
- Cystic Fibrosis Research Advances
- Craniofacial Disorders and Treatments
- Genetic Syndromes and Imprinting
- Electrochemical Analysis and Applications
- Soil Carbon and Nitrogen Dynamics
- Protein Structure and Dynamics
- Liver physiology and pathology
- Cleft Lip and Palate Research
Albert Einstein College of Medicine
2024-2025
Cardiovascular Institute Hospital
2025
Jinan University
2022-2025
Air Force Medical University
2021-2025
Wuyi University
2024
National Institutes of Health
2017-2024
Chinese Academy of Sciences
2020-2024
Jiangsu Academy of Agricultural Sciences
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Xijing Hospital
2024
Abstract Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate abnormally in presence reactive oxygen species (ROS) elevated oxidation. Here we show, using collagen-induced (CIA) mouse model, imidazole ketone erastin (IKE), ferroptosis inducer, decreases fibroblast numbers synovium. Data from single-cell RNA sequencing further identify two groups have...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by excessive proliferation of fibroblasts and accumulation extracellular matrix (ECM). Ferroptosis novel form cell death the lethal iron lipid peroxidation, which associated with many diseases. Our study addressed potential role played ferroptosis in progression fibrosis. We found that inducers injury, namely, bleomycin (BLM) lipopolysaccharide (LPS), induced lung epithelial cells. Both inhibitor...
Oxidative stress and lipid peroxidation are major causes of skin injury induced by ultraviolet (UV) irradiation. Ferroptosis is a form regulated necrosis driven iron-dependent phospholipids contributes to kinds tissue injuries. However, it remains unclear whether the accumulation peroxides in UV irradiation-induced could lead ferroptosis. We generated mice model examine iron. Lipid 4-HNE, oxidative enzyme COX2, DNA damage biomarker 8-OHdG, iron level were increased skin. The was also...
Pathogenic bacterial infections, exacerbated by increasing antimicrobial resistance, pose a major threat to human health worldwide. Extracellular vesicles (EVs), secreted bacteria and acting as their "long-distance weapons", play an important role in the occurrence development of infectious diseases. However, no efficient methods rapidly detect identify EVs different origins are available. Here, label-free Raman spectroscopy combination with new deep learning model attentional neural network...
Ferroptosis, a form of programmed cell death process driven by iron-dependent lipid peroxidation, plays an important role in tumor suppression. Although previous study showed that intracellular Merlin-Hippo signaling suppresses ferroptosis epithelial cells through the inactivation YAP signaling, it remains elusive if proto-oncogenic transcriptional co-activator could serve as potential biomarker to predict cancer response ferroptosis-inducing therapies. In this study, we show both total...
Abstract A major obstacle to therapy in intensive care units is sepsis caused by severe infection. In recent years gram-positive (G + ) bacteria, most commonly staphylococci, are thought be the main pathogens. Micheliolide (MCL) was demonstrated provide a therapeutic role rheumatoid arthritis, inflammatory intestinal disease, colitis-associated cancer, and lipopolysaccharide (LPS, component of G − bacterial cell wall) induced septic shock. We proved here that MCL played an anti-inflammatory...
Molecular vibrational spectroscopies, including infrared absorption and Raman scattering, provide molecular fingerprint information are powerful tools for qualitative quantitative analysis. They benefit from the recent development of deep-learning-based algorithms to improve spectral, spatial, temporal resolutions. Although a variety algorithms, those simultaneously extract global local spectral features, have been developed classification, classification accuracy is still far satisfactory...
Ferroptosis, an iron-dependent form of regulated cell death, is characterized by the lethal accumulation lipid peroxides on cellular membranes. It not only inhibits tumor growth but also enhances immunotherapy responses and overcomes drug resistance in cancer therapy. The inhibition cystine-glutamate antiporter, system Xc-, induces ferroptosis. Imidazole ketone erastin (IKE), inhibitor Xc- functional subunit solute carrier family 7 member 11 (SLC7A11), effective metabolically stable inducer...
The identification of factors that lead to CD8⁺ T cell dysfunction within the tumor microenvironment (TME) holds great promise for development innovative immunotherapies. However, precise mechanisms underlying exhausted phenotype cells infiltrating early-stage hepatocellular carcinoma (HCC) tumors remains unclear. Single-cell RNA sequencing was performed using a murine HCC model. Flow cytometry and additional experimental approaches were employed investigate exhaustion. CD8+ exhibited...
Extracellular vesicles (EVs) are newly recognized as important vectors for carrying and spreading antibiotic resistance genes (ARGs). However, the ARGs harbored by EVs in ambient environments transfer potential still unclear. In this study, prevalence of mobile genetic elements (MGEs) their microbial origins were studied indoor dust from restaurants, kindergarten, dormitories, vehicles. The amount ranged 3.40 × 107 to 1.09 1011 particles/g dust. length EV-associated DNA fragments was between...
Aberrant HGF/Met signaling promotes tumor migration, invasion, and metastasis through both autocrine non‐autocrine mechanisms; however, the molecular downstream mechanisms by which induces are incompletely understood. We here report that Ezrin expression is stimulated HGF correlates with activated HGF/Met, indicating regulates of Ezrin. show activates transcription factor Sp1 MAPK pathway, can in turn directly bind to promoter gene regulate its transcription. Notably, knockdown shRNAs...
Treatment with electroacupuncture (EA) at ST25 and CV12 has a significant analgesic effect on postinflammatory irritable bowel syndrome (PI-IBS) visceral pain. Enterochromaffin (EC) cells serotonin (5-hydroxytryptamine (5-HT)) are important in the development of hyperalgesia.To investigate underlying mechanisms EA treatment trinitrobenzene sulfonic acid (TNBS)-induced PI-IBS hyperalgesia rats.After CV12, changes abdominal withdrawal reflex (AWR), electromyography (EMG) recordings, colonic EC...
Abstract Exchange of mobile functional genes within microbiota benefits the microbial community. However, status gene pool in environment is still largely unclear, impeding understanding on process transfer natural communities. The release extracellular vesicles (EVs) by diverse organisms has been proposed to be a vital way complex networks interactions between microbes and their habitats. In this study, we hypothesized that EVs encapsulating DNA are widely distributed environmental matrix....
A novel electrochemical biosensor based on exonuclease III-aided autonomous cascade signal amplification for the ultrasensitive and highly specific detection of <italic>S. typhimurium</italic>.
Abstract Targeting mutant BRAF in patients with melanomas harboring this oncogene has been highly successful as a first-line treatment, but other mutations may affect its efficacy and alter the route of acquired resistance resulting recurrence poor prognosis. As an evolving strategy, melanoma treatment needs to be expanded include targets based on newly discovered emerging molecules pathways. We here show that PERK plays critical role inhibitor-acquired impaired PTEN. Inhibition by either...
The development of three-dimensional (3D) molecular generative model based on protein pockets has recently attracted a lot attentions. This type aims to achieve the simultaneous generation graph and 3D binding conformation under constraint binding. Various pocket models have been proposed, however, currently there is lack systematic objective evaluation metrics for these models. To address this issue, comprehensive benchmark dataset, named as POKMOL-3D, proposed evaluate It includes 32...
The development of three-dimensional (3D) molecular generative model based on protein pockets has recently attracted a lot attentions. This type aims to achieve the simultaneous generation graph and 3D binding conformation under constraint binding. Various pocket models have been proposed, however, currently there is lack systematic objective evaluation metrics for these models. To address this issue, comprehensive benchmark dataset, named as POKMOL-3D, proposed evaluate It includes 32...
The development of three-dimensional (3D) molecular generative model based on protein pockets has recently attracted a lot attentions. This type aims to achieve the simultaneous generation graph and 3D binding conformation under constraint binding. Various pocket models have been proposed, however, currently there is lack systematic objective evaluation metrics for these models. To address this issue, comprehensive benchmark dataset, named as POKMOL-3D, proposed evaluate It includes 32...
The development of a three-dimensional (3D) molecular generative model based on protein pockets has recently attracted lot attention. This type aims to achieve the simultaneous generation graphs and 3D binding conformation under constraint binding. Various pocket-based models have been proposed; however, currently, there is lack systematic objective evaluation metrics for these models. To address this issue, comprehensive benchmark data set, named POKMOL-3D, proposed evaluate It includes 32...