A5038972351- Autophagy in Disease and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Traditional Chinese Medicine Analysis
- Lipid metabolism and disorders
- Platelet Disorders and Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Ginseng Biological Effects and Applications
- Biomarkers in Disease Mechanisms
- Nuclear Receptors and Signaling
- Computational Drug Discovery Methods
- Neuroblastoma Research and Treatments
- Acute Myocardial Infarction Research
- Cancer-related molecular mechanisms research
- Medicinal Plants and Bioactive Compounds
- Mesenchymal stem cell research
- Medicinal Plant Extracts Effects
- Hearing, Cochlea, Tinnitus, Genetics
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Heart Failure Treatment and Management
- Autoimmune Bullous Skin Diseases
- Inflammasome and immune disorders
- Traditional Chinese Medicine Studies
- Saffron Plant Research Studies
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2020-2024
Guangzhou University of Chinese Medicine
2022
To assess geniposide's effects in New Zealand rabbits with high-fat diet induced atherosclerosis and to explore the underpinning mechanisms. Aorta histological changes were evaluated by intravenous ultrasound (IVUS) H&E staining. Lipid accumulation aortic was quantified Oil Red O Then, RNA sequencing (RNA-seq) carried out for detecting differentially expressed genes rabbit atherosclerosis. The levels of cytokines CRP, IL-1β IL-10 determined ELISA. Protein iNOS Arg-1 assessed Western blot...
Huanglian Jiedu Decoction (HLJDD) is a Chinese medicine with long history of therapeutic application. It widely used in treating atherosclerosis (AS) theory and clinical practice. However, the mechanism HLJDD AS remains unclear. To investigate efficacy AS. was induced on high-fat diet-fed ApoE−/− mice, aorta pathological changes evaluated lipid content plaque progression. In vitro, foam cells were by subjecting primary mouse aortic vascular smooth muscle (VSMCs) to oxLDL incubation. After...
Context Qingre Huoxue (QRHX) decoction, a traditional Chinese medicine, has been widely used to prevent and treat myocardial infarction (MI).Objective This study elucidates the possible mechanisms of QRHX in preventing or treating MI rat model.Materials methods The chemical constituents were identified by UPLC-MS. Sprague-Dawley rats randomly divided into Sham (normal saline), Model QRHX-L, QRHX-M QRHX-H group (n = 10 per group). decoction was administered gavage for 14 days (5, 20...
Qingre Huoxue Decoction (QRHX) is a classical Chinese herbal prescription widely used in clinical practice for the treatment of atherosclerosis (AS). Our previous study demonstrated its efficacy stabilizing plaque and improving prognosis, as well ability to regulate macrophage polarization. This aimed further investigate effects QRHX on AS explore underlying mechanisms.
is an herbal medicine widely used in the treatment of atrial fibrillation (AF), but mechanism unclear.
Sick sinus syndrome (SSS), a complex type of cardiac arrhythmia, is major health threat to humans. Shenfu injection (SFI), formula traditional Chinese medicine (TCM), effective in improving bradyarrhythmia. However, the underlying mechanism SFI's therapeutic effect subject few systematic investigations. The purpose present research examine whether SFI can boost differentiation effectiveness bone marrow mesenchymal stem cells (BMSCs) into pacemaker-like and transplantation these improve...
Objective. This study aimed to determine the active ingredients of Huanglian Jiedu decoction (HLJDD) and targets for treating dyslipidemia through network pharmacology facilitate further application HJJDD in treatment dyslipidemia. Methods. Potential drug were identified with a protein-protein interaction network. Gene ontology (GO) enrichment analysis KEGG pathway performed elucidate biological function major pathways involved HLJDD-mediated Results. approach revealed 22 components, 234...
In patients with severe acute respiratory syndrome coronavirus 2 (which causes disease 2019 [COVID-19]), oxidative stress (OS) is associated severity and death. OS also involved in the pathogenesis of atherosclerosis (AS). Previous studies have shown that geniposide has anti-inflammatory anti-viral properties, can protect cells against OS. However, potential target(s) COVID-19 AS, as well mechanism it uses, are unclear. We combined pharmacology bioinformatics analysis to obtain COVID-19/AS...
We investigated the effects of Shenfu Injection (SFI) on HCN4 activity in bone marrow mesenchymal stem cells (BMSCs). The sample BMSCs was divided into six groups: a control group, high-dose SFI group (0.25 ml/ml), middle-dose (0.1 low-dose (0.05 an adenovirus-encoded vector and group. Cell ultrastructure observed using transmission electron microscope. Quantitative reverse transcription PCR (RT-qPCR) performed to detect expression, detected whole-cell patch clamp technique. An enzyme-linked...
Heart failure (HF), manifested as a severe or end stage of various cardiac diseases, is characterized by increased incidence, mortality, re-hospitalization, and economic burden. Myocardial infarction (MI) one the most common important causes HF. Since 2005, acute MI (AMI)-associated mortality in China has been on rise, accounts for 23.1% Traditional Chinese medicine (TCM) unique advantages controlling angina pectoris HF symptoms, improving patients' quality life. Compound Xueshuantong...
Abstract Background Heyde’s syndrome can be easily overlooked or misjudged in clinical practice because it shares common manifestations with multiple diseases as well limited accuracy of several corresponding examinations for diagnosing triad. Moreover, aortic valve replacement is often delayed these patients due to the contradiction between anticoagulation and hemostasis. Herein, we present a rare case atypical syndrome. The patient’s severe intermittent gastrointestinal bleeding was not...
Abstract Background: Heyde’s syndrome can be easily overlooked or misjudged in clinical practice because it shares common manifestations with multiple diseases and of the limited accuracy corresponding examinations for diagnosing triad. Moreover, aortic valve replacement is often delayed these patients contradiction between anticoagulation haemostasis. Herein, we present a rare case atypical Heyde's syndrome. The patient's severe intermittent gastrointestinal bleeding was not completely...