A5101573520- Genetic Associations and Epidemiology
- Cardiovascular Function and Risk Factors
- Chemical Synthesis and Analysis
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Gut microbiota and health
- Traditional Chinese Medicine Studies
- Pharmacy and Medical Practices
- Technology and Data Analysis
- Acupuncture Treatment Research Studies
- Microbial Natural Products and Biosynthesis
- Biofield Effects and Biophysics
- Hearing, Cochlea, Tinnitus, Genetics
- Plant-based Medicinal Research
- RNA modifications and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Medicinal Plants and Bioactive Compounds
- Traditional Chinese Medicine Analysis
- Synthesis and Catalytic Reactions
Guangzhou University of Chinese Medicine
2020-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2022
Southern Medical University
2020
Nanfang Hospital
2020
Nanjing University
2006
Abstract Basal metabolic rate (BMR) is associated with cardiovascular health; however, the causal relationship between BMR and risk of diseases (CVDs) remains unclear. This study aimed to investigate potential on common CVDs including aortic aneurysm (AA), atrial fibrillation flutter (AFF), calcific valvular stenosis (CAVS), heart failure (HF), myocardial infarction (MI) by Mendelian randomization (MR). The univariable MR analysis using inverse variance weighted (IVW) model as primary method...
A hybrid trans-AT PKS/NRPS gene cluster htm was identified with defined boundaries for hangtaimycin biosynthesis in Streptomyces spectabilis CPCC200148. Deoxyhangtaimycin, a new derivative of hangtaimycin, from the htm11 knockout mutant. In vitro biochemical assays demonstrated that cytochrome P450 monooxygenase Htm11 responsible stereoselective hydroxylation deoxyhangtaimycin to hangtaimycin. More importantly, showed activity against influenza virus at micromolar level, highlighting its...
Artemisia vestita Wall., a traditional Tibetan medicine, has wide clinical application for inflammatory diseases. However, its molecular mechanism of anti-inflammatory effect is poorly understood. In the present study, we investigated activity and underlying ethanol extract from (AV-ext) on lipopolysaccharide (LPS)-induced sepsis. Pretreatment with AV-ext significantly decreased levels tumor necrosis factor-alpha (TNF-alpha) in serum liver lung tissues, improved survival mice experimental...
Sick sinus syndrome (SSS), a complex type of cardiac arrhythmia, is major health threat to humans. Shenfu injection (SFI), formula traditional Chinese medicine (TCM), effective in improving bradyarrhythmia. However, the underlying mechanism SFI's therapeutic effect subject few systematic investigations. The purpose present research examine whether SFI can boost differentiation effectiveness bone marrow mesenchymal stem cells (BMSCs) into pacemaker-like and transplantation these improve...
Background The gut microbiota (GM) is widely acknowledged to have a significant impact on cardiovascular health and may act as residual risk factor affecting cardiac structure function. However, the causal relationship between GM function remains unclear. Objective This study aims employ two-sample Mendelian randomization (MR) approach investigate association Methods Data 119 genera were sourced from genome-wide (GWAS) meta-analysis (13,266 European participants) conducted by MiBioGen...
Acute myocardial infarction (AMI) is the most severe type of coronary heart disease and patients often require percutaneous intervention (PCI). However, anxiety depression are common complications PCI.
Abstract Introduction: Sick sinus syndrome (SSS) is a common cardiovascular disease without available oral drugs for long-term routine treatment, which can be treated by Shenfu Decoction (SFD) according to Traditional Chinese Medicine (TCM) clinical applications. The purpose of this research decode the therapeutic mechanisms SFD in treating SSS as well interpret synergistic relationship herbs through method systematic pharmacology. Methods: We established novel pharmacological model,...