A5085544934- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- RNA Research and Splicing
- Bioactive Natural Diterpenoids Research
- Phytochemistry and Biological Activities
- Polyamine Metabolism and Applications
- Escherichia coli research studies
- Inflammasome and immune disorders
- Gut microbiota and health
- Plant-based Medicinal Research
- Immune Response and Inflammation
- Herbal Medicine Research Studies
- Hepatitis B Virus Studies
- Fungal Biology and Applications
- Hepatitis C virus research
- Congenital heart defects research
- Single-cell and spatial transcriptomics
- Phytochemistry and Bioactivity Studies
- Hydrogen's biological and therapeutic effects
- Genomics and Chromatin Dynamics
- Fibroblast Growth Factor Research
- Cancer Mechanisms and Therapy
- Hearing, Cochlea, Tinnitus, Genetics
- Light effects on plants
Advanced Research Institute
2024
Jiangxi College of Applied Technology
2024
Yale University
2012-2023
Beijing University of Chinese Medicine
2009-2020
ORCID
2020
National Institute of Dental and Craniofacial Research
2020
Albany State University
2019
University at Albany, State University of New York
2019
John Wiley & Sons (United States)
2016
W. M. Keck Foundation
2012
Escherichia coli is a common inhabitant of the human microbiota and beacon model organism in biology. However, an understanding its signaling systems that regulate population-level phenotypes known as quorum sensing remain incomplete. Here, we define structure biosynthesis autoinducer-3 (AI-3), metabolite previously unknown involved pathogenesis enterohemorrhagic E. (EHEC). We demonstrate novel AI-3 analogs are derived from threonine dehydrogenase (Tdh) products "abortive" tRNA synthetase...
γδ T cells are an abundant cell population at the mucosa and important in providing immune surveillance as well maintaining tissue homeostasis. However, despite cells’ origin thymus, detailed mechanisms regulating development remain poorly understood. N 6 -methyladenosine (m A) represents one of most common posttranscriptional modifications messenger RNA (mRNA) mammalian cells, but whether it plays a role biology is still unclear. Here, we show that depletion m A demethylase ALKBH5...
Abstract Inflammatory bowel diseases (IBD) are known to have complex, genetically influenced etiologies, involving dysfunctional interactions between the intestinal immune system and microbiome. Here, we characterized how RNA transcript from an IBD-associated long non-coding locus (“ CARINH - C olitis A ssociated IRF1 antisense R egulator of In testinal H omeostasis”) protects against IBD. We show that its neighboring gene coding for transcription factor together form a feedforward loop in...
RNA helicase DHX9 has been extensively characterized as a transcriptional regulator, which is consistent with its mostly nucleic localization. It also involved in recognizing viruses the cytoplasm. However, there no vivo data to support antiviral role of DHX9; meanwhile, nuclear protein, if and how promotes immunity remains largely unknown. Here, we generated myeloid-specific hepatocyte-specific knockout mice confirmed that crucial for host resistance virus infections vivo. By additional...
Abstract The stria vascularis (SV) in the cochlea generates and maintains endocochlear potential, thereby playing a pivotal role normal hearing. Knowing transcriptional profiles gene regulatory networks of SV cell types establishes basis for studying mechanism underlying SV-related hearing loss. While we have previously characterized expression major adult mouse, rare remained elusive due to limitation capture single-cell RNA-Seq. these homeostatic function remain largely undefined. In this...
Significance RNA helicases play critical roles in multiple biological processes. However, little vivo data are available because of the lethality mice completely deficient helicases. Here, we generate with conditional knockout DEAD-box Helicase 15 (Dhx15) intestine, which found a specific defect antimicrobial peptide (AMP) α-defensins Paneth cells. Additionally, that Dhx15-specific depletion intestine leads to susceptibility enteric bacterial infection as well dextran sulfate sodium-induced...
Lysine lactylation (Kla) is a new type of histone mark implicated in the regulation various functional processes such as transcription. However, how this acts cancers remains unexplored due part to lack knowledge about its reader proteins. Here, we observe that cervical cancer (CC) cells undergo metabolic reprogram by which lactate accumulation and thereby boosts lactylation, particularly H3K14la. Utilizing multivalent photoaffinity probe combination with quantitative proteomics approach,...
Hepatitis C virus (HCV) is the most common chronic blood-borne infection in United States, with majority of patients becoming chronically infected and a subset (20%) progressing to cirrhosis hepatocellular carcinoma. Individual variations immune responses may help define successful resistance HCV. We have compared response primary macrophages from who spontaneously cleared HCV (viral load negative [VL-], n = 37) that genotype 1 (VL+) subjects (n 32) found VL- an elevated baseline expression...
Tapinarof is a stilbene drug that used to treat psoriasis and atopic dermatitis, thought function through regulation of the AhR Nrf2 signaling pathways, which have also been linked inflammatory bowel diseases. It produced by gammaproteobacterial Photorhabdus genus, thus represents model probe tapinarof structural functional transformations. We show transforms into novel metabolism products kill bacteria, cupin enzyme contributes conversion related dietary stilbenes dimers. One dimer has...
Artemisia vestita Wall., a traditional Tibetan medicine, has wide clinical application for inflammatory diseases. However, its molecular mechanism of anti-inflammatory effect is poorly understood. In the present study, we investigated activity and underlying ethanol extract from (AV-ext) on lipopolysaccharide (LPS)-induced sepsis. Pretreatment with AV-ext significantly decreased levels tumor necrosis factor-alpha (TNF-alpha) in serum liver lung tissues, improved survival mice experimental...
The identification of network targets is one the core issues used to reveal molecular mechanism traditional Chinese medicine (TCM) and also grand challenge modernization TCM. In this study, a protein-protein interaction (PPI) was constructed based on integration pharmacology metabolomics, which as an effective approach elucidate relationship between disease pathway proteins active small-molecule compounds. intermolecular transfer process drug effect compounds in Salvia miltiorrhiza (SM)...
Abstract Tapinarof is a stilbene drug that used to treat psoriasis and atopic dermatitis, thought function through regulation of the AhR Nrf2 signaling pathways, which have also been linked inflammatory bowel diseases. It produced by gammaproteobacterial Photorhabdus genus, thus represents model probe tapinarof structural functional transformations. We show transforms into novel metabolism products kill bacteria, cupin enzyme contributes conversion related dietary stilbenes dimers. One dimer...
AgrC is a membrane-embedded histidine kinase in Staphylococcus aureus that thought to act as sensor for the recognition of environmental signals and transduction into cytoplasm so regulate control series related pathogenic gene expression. However, complexity cell membrane, it turns be difficult study on bacterial membrane directly. Many researches tried take advantage proteoliposome which could provide an approximate natural environment keep protein activity structure function proteins. In...
A biomimetic synthesis of hitorins and B was achieved based on our modified biosynthetic proposal. In synthesis, a radical cascade reaction between an alkoxy radical, generated from hydroperoxide, monoterpene (+)-sabinene renders the tetrahydrofuran ring B. addition, experimental results supported that oxidative cleavage tetrasubstituted olefin in key intermediate is via oxidation followed by Grob fragmentation.