A5030477051- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Neurotransmitter Receptor Influence on Behavior
- MicroRNA in disease regulation
- Gut microbiota and health
- Nerve injury and regeneration
- Zebrafish Biomedical Research Applications
- Escherichia coli research studies
- RNA Research and Splicing
- Wnt/β-catenin signaling in development and cancer
- Extracellular vesicles in disease
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Antibiotic Resistance in Bacteria
- Drug-Induced Hepatotoxicity and Protection
- Receptor Mechanisms and Signaling
- Hypothalamic control of reproductive hormones
- Sulfur Compounds in Biology
- Diet and metabolism studies
- Stress Responses and Cortisol
- Birth, Development, and Health
- Nitric Oxide and Endothelin Effects
- Trace Elements in Health
- Neuroendocrine regulation and behavior
- Aerodynamics and Acoustics in Jet Flows
Rutgers, The State University of New Jersey
2023-2024
Douglas Mental Health University Institute
2016-2023
McGill University
2016-2023
The University of Texas Southwestern Medical Center
2018-2022
University of Wisconsin–Madison
2022
National University of Rosario
2010-2020
Southwestern Medical Center
2020
Centro Científico Tecnológico - San Juan
2016
Centro Científico Tecnólogico - Rosario
2016
Consejo Nacional de Investigaciones Científicas y Técnicas
2016
Escherichia coli is a common inhabitant of the human microbiota and beacon model organism in biology. However, an understanding its signaling systems that regulate population-level phenotypes known as quorum sensing remain incomplete. Here, we define structure biosynthesis autoinducer-3 (AI-3), metabolite previously unknown involved pathogenesis enterohemorrhagic E. (EHEC). We demonstrate novel AI-3 analogs are derived from threonine dehydrogenase (Tdh) products "abortive" tRNA synthetase...
Gut-microbiota membership is associated with diverse neuropsychological outcomes, including substance use disorders (SUDs). Here, we mice colonized Citrobacter rodentium or the human γ-Proteobacteria commensal Escherichia coli HS as a model to examine mechanistic interactions between gut microbes and host responses cocaine. We find that cocaine exposure increases intestinal norepinephrine levels are sensed through bacterial adrenergic receptor QseC promote colonization of γ-Proteobacteria....
Initiating drug use during adolescence increases the risk of developing addiction or other psychopathologies later in life, with long-term outcomes varying according to sex and exact timing use. The cellular molecular underpinnings explaining this differential sensitivity detrimental effects remain unexplained. Netrin-1/DCC guidance cue system segregates cortical limbic dopamine pathways adolescence. Here we show that amphetamine, by dysregulating signaling, triggers ectopic growth...
Abstract The guidance cue receptor DCC controls mesocortical dopamine development in adolescence. Repeated exposure to an amphetamine regimen of 4 mg/kg during early adolescence induces, male mice, downregulation expression neurons by recruiting the Dcc microRNA repressor, microRNA‐218 (miR‐218). This adolescent also disrupts connectivity and behavioral control adulthood. Whether low doses induce similar molecular developmental effects needs be established. Here, we quantified plasma...
The fine arrangement of neuronal connectivity during development involves the coordinated action guidance cues and their receptors. In adolescence, dopamine circuitry is still developing, with mesolimbic axons undergoing target-recognition events in nucleus accumbens, while mesocortical projections continue to grow towards prefrontal cortex until adulthood. This segregation versus pathways mediated by cue receptor DCC, which signals intended innervate accumbens recognize this region as final...
Abstract Cocaine addiction is a chronic relapsing disorder characterized by the loss of control over drug‐seeking and taking, continued drug use regardless adverse consequences. Despite years research, effective treatments for psycho‐stimulant have not been identified. Persistent vulnerability to relapse arises from number long‐lasting adaptations in reward circuitry that mediate enduring response drug. Recently, we reported activity canonical or Wnt/β‐catenin pathway prefrontal cortex (PFC)...
Abstract Behavioral sensitization is a progressive and enduring enhancement of the motor stimulant effects elicited by repeated administration drugs abuse. It can be divided into two distinct temporal anatomical domains, termed initiation expression, which are characterized specific molecular neurochemical changes. This study examines role Wnt canonical pathway mediating induction cocaine sensitization. We found that β‐catenin levels in prefrontal cortex (PFC), amygdala (Amyg) dorsal...
Abstract Fetal restriction (FR) alters insulin sensitivity, but it is unknown how the metabolic profile associated with affects development of dopamine (DA) system and DA-related behaviors. The Netrin-1/DCC guidance cue participates in maturation mesocorticolimbic DA circuitry. Therefore, our objective was to identify if FR modifies receptor protein expression prefrontal cortex (PFC) at birth mRNA adulthood rodent males. We used cultured HEK293 cells assess levels miR-218, microRNA regulator...
ABSTRACT Adolescence is a period of increased vulnerability to psychiatric disorders including depression. Discovering novel biomarkers identify individuals who are at high risk very much needed. Our previous work shows that the microRNA miR-218 mediates susceptibility stress and depression in adulthood, by targeting Netrin-1 guidance cue receptor gene Dcc ( D eleted c olorectal ancer ) medial prefrontal cortex (mPFC). Here we investigated whether regulates expression adolescence could serve...
ABSTRACT Low miR-218 expression in the medial prefrontal cortex (mPFC) is a consistent trait of depression. Here we assessed whether mPFC confers resilience or susceptibility to depression-like behaviors adult mice, using chronic social defeat stress (CSDS) model We also investigated stress-induced variations can be detected blood. find that downregulation increases single session defeat, whereas overexpression selectively pyramidal neurons promotes CSDS and prevents morphological...
Abstract Initiating drug use during adolescence increases the risk of developing addiction and psychiatric disorders later in life, with long-term outcomes varying according to sex exact timing use. Even though most individuals begin experimenting drugs abuse adolescence, date, cellular molecular underpinnings explaining differential sensitivity detrimental effects remain unknown. The Netrin-1/DCC guidance cue system plays a critical role adolescent development mesocorticolimbic dopamine...