A5101666363- Cancer-related molecular mechanisms research
- Endometriosis Research and Treatment
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
- Circular RNAs in diseases
- Ovarian function and disorders
- Immunodeficiency and Autoimmune Disorders
- Immunotherapy and Immune Responses
- Traditional Chinese Medicine Studies
- Reproductive Biology and Fertility
- Cardiovascular and exercise physiology
- RNA modifications and cancer
- Respiratory viral infections research
- Heart Rate Variability and Autonomic Control
- T-cell and B-cell Immunology
- Myasthenia Gravis and Thymoma
- Physical Activity and Health
- Obesity, Physical Activity, Diet
- Cervical Cancer and HPV Research
- Respiratory Support and Mechanisms
- Multiple Myeloma Research and Treatments
- Vascular Malformations and Hemangiomas
- Hormonal and reproductive studies
Shanghai Jiao Tong University
2022-2025
Guangdong Pharmaceutical University
2025
Second Affiliated Hospital of Nanchang University
2018-2024
Nanchang University
2011-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2024
Southern Medical University
2021-2024
University of Hong Kong
2018-2024
Shenzhen University
2023-2024
Zhujiang Hospital
2023-2024
Hong Kong Science and Technology Parks Corporation
2024
<h3>Importance</h3> Recent studies have shown an association between psoriasis and nonalcoholic fatty liver disease (NAFLD) in US inpatients, but the is still unclear outpatient population. <h3>Objective</h3> To assess whether associated with NAFLD adults. <h3>Design, Setting, Participants</h3> This population-based cross-sectional study used data on adults aged 20 to 59 years from National Health Nutrition Examination Survey (NHANES) 2003-2006 2009-2014 cycles. Data were analyzed June...
Abstract Lung injury and fibrosis represent the most significant outcomes of severe acute lung disorders, including COVID-19. However, there are still no effective drugs to treat fibrosis. In this study, we report generation clinical-grade human embryonic stem cells (hESCs)-derived immunity- matrix-regulatory (IMRCs) produced under good manufacturing practice requirements, that can in vivo. We generate IMRCs by sequentially differentiating hESCs with serum-free reagents. possess a unique...
Alcoholic liver injury, known as the most general result of chronic alcohol intake, is induced by inflammatory responses, which activated intestine-derived endotoxins formed from intestinal dysbiosis. The hepatoprotective activity rice bran phenolic extract (RBPE) on ethanol-fed mice was investigated for first time in this study, and underlying mechanism explored gut microbiota, barrier function, hepatic inflammation. Mice were fed an alcohol-containing liquid diet alone or mixture with RBPE...
The aim of this paper was to conduct a baseline survey HPV infection in unvaccinated women Xinjiang Uyghur Autonomous Region before the mass use vaccine. Between 2008 and 2018, genotype detected by PCR-based hybridization gene chip assay 37,722 who were from Gynecology Department Health Management Center First Affiliated Hospital Medical University tested assay. All statistical analysis methods performed with software including Python version 3.6.1, R Software 3.5.1 Excel 2011. total...
Abstract Background The role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the pathogenesis testicular damage is uncertain. Methods We investigated virological, pathological, and immunological changes testes hamsters challenged by wild-type SARS-CoV-2 its variants with intranasal or direct inoculation using influenza virus A(H1N1)pdm09 as control. Results Besides self-limiting tract infection, challenge caused decrease sperm count, serum testosterone inhibin B at 4–7...
Pain is more prevalent in women for reasons that remain unclear. We have identified a mechanism of injury-free nociceptor sensitization and opioid-induced hyperalgesia (OIH) promoted by prolactin (PRL) females. PRL signals through mutually inhibitory long (PRLR-L) short (PRLR-S) receptor isoforms, PRLR-S activation induces neuronal excitability. PRLR expression were higher CRISPR-mediated editing PRLR-L allodynia naïve, uninjured female mice depended on circulating PRL. Opioids, but not...
To investigate the ability of quercetin to improve ovarian function and inhibit oxidative stress through PI3K/Akt/FoxO3a signalling pathway in a rat model premature failure (POF), we constructed POF with cyclophosphamide (CTX) treated it quercetin. Haematoxylin eosin staining (H&E staining) was used observe morphological changes ovaries. The serum levels AMH, E2, FSH, SOD, GSH-Px MDA were determined by enzyme-linked immunosorbent assays. expression phosphatidylinositol 3-kinase (PI3K),...
Abstract Migraine headache results from activation of meningeal nociceptors, however, the hypothalamus is activated many hours before emergence pain. How hypothalamic neural mechanisms may influence trigeminal nociceptor function remains unknown. Stress a common migraine trigger that engages dynorphin/kappa opioid receptor (KOR) signalling and increases circulating prolactin. Prolactin acts at both long short prolactin isoforms are expressed in afferents. Following downregulation isoform,...
Hyperglycemia accelerates the development of diabetic nephropathy (DN) by inducing renal tubular injury. Nevertheless, mechanism has not been elaborated fully. Here, pathogenesis DN was investigated to seek novel treatment strategies.A model established in vivo, levels blood glucose, urine albumin creatinine ratio (ACR), creatinine, urea nitrogen (BUN), malondialdehyde (MDA), glutathione (GSH), and iron were measured. The expression detected qRT-PCR Western blotting. H&E, Masson, PAS...
To investigate the clinical significance of miR-335 expression in epithelial ovarian cancer (EOC).Expression normal ovaries, EOC, and omental metastases was determined by quantitative realtime polymerase chain reaction. Overall survival (OS) relapse-free (RFS) were examined using KaplanMeier curves Cox proportional hazards regression model.miR-335 level reduced malignant tissue samples, especially metastases. Low levels EOC associated with shorter OS (P < .001) RFS = .002). In multivariate...
To investigate the effects of quercetin on ovulation disorder and expression androgen receptor (AR) C-type natriuretic peptide (CNP) / Natriuretic Peptide Receptor 2 (NPR2) in dehydroepiandrosterone (DHEA)-induced polycystic ovary syndrome (PCOS) rat model. DHEA was used to construct PCOS After intervention with quercetin, metformin, AR, estrous cycle, ovarian uterine weight rats were measured. The morphological changes detected by hematoxylin-eosin staining (HE staining). Luteinizing...
<b><i>Introduction:</i></b> Objectives of the study were to investigate correlation between optical coherence tomography (OCT)-based grading diabetic macular edema (DME) and systemic inflammatory indices, imaging biomarkers, early anti-vascular endothelial growth factor (VEGF) treatment response. <b><i>Methods:</i></b> A total 111 eyes from patients with DME treated intravitreous anti-VEGF therapy for 3 consecutive months every month enrolled...
This study aims to assess anxiety severity among patients with and elucidate the predominant psychological factors, informing development of targeted management strategies. The cross-sectional recruited 421 GDM via convenience sampling from Guangdong Province, China. Self-administered questionnaires, including Pregnancy-related Anxiety Scale, Simplified Coping Style Questionnaire, Type D Personality Perceived Social Support General Self-Efficacy were utilized gather data. Data analysis was...
: Genotype distribution and prevalence of human papillomavirus (HPV) among women vary from different regions crowds, prophylactic HPV vaccin could prevent some diseases related to HPV, which include cervical precancerous lesions cancer. Baseline surveys prior mass vaccination are critical determine vaccine efficacy detect changes in type after vaccination.
Steroid receptor RNA activator 1 (SRA1) has been described as a novel transcriptional co-activator that affects the migration of cancer cells. Through RT-PCR, we identified skipping exon 3 SRA1 produces two isoforms, including truncated short isoform, SRA1-S, and long SRA1-L. However, effect these isomers on HCC cells, well specific mechanism remain unclear. In this study, found up regulated expression SRSF1 SRA1-L in highly metastatic HCCLM3, HCCs with demonstrating strongest correlation...
The free and bound phenolic profiles their bioactivities of radix puerariae thomsonii (RPT) cultivars from 7 growing regions in China were investigated. Total flavonoid contents 148.71 to 435.32 mg gallic acid equivalents /100 g dry weight 561.93 826.11 catechin weight, respectively, with 20.64–38.28% 32.77–47.29% contribution fractions. Sixteen compounds detected RPTs. Bound fractions contributed 28.15–70.84% the total antioxidant activities. Qiannan Guangzhou showed much higher regulatory...
Chronic kidney disease (CKD) lacks effective treatments and renal fibrosis (RF) is one of CKD's outcomes. Dickkopf 3 (DKK3) has been identified as an agonist in CKD. However, the underlying mechanisms DKK3 CKD are not fully understood.
It has been confirmed the lipid-lowering effect of rice bran free phenolics, but it is unknown whether bound phenolic profile which differs from ones, have a similar effect. Thus, hypolipidemic and potential mechanism hydrolyzed phenolics (HBP) was investigated in this study. The results showed that HBP supplementation significantly improved serum lipid profiles high-fat-diet fed mice. inhibited activation nuclear receptors liver X receptor-α (LXRα), sterol regulatory element binding protein...