A5103282121- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Chronic Kidney Disease and Diabetes
- Cardiovascular Function and Risk Factors
- Renal and related cancers
- Ferroptosis and cancer prognosis
- Parathyroid Disorders and Treatments
- Dialysis and Renal Disease Management
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Computational Drug Discovery Methods
- Neurogenesis and neuroplasticity mechanisms
- Genomics, phytochemicals, and oxidative stress
- Connective tissue disorders research
- Telomeres, Telomerase, and Senescence
- Congenital heart defects research
- Signaling Pathways in Disease
- Silk-based biomaterials and applications
- Chemical synthesis and alkaloids
- Synthesis and Catalytic Reactions
- Nerve injury and regeneration
- Cardiac electrophysiology and arrhythmias
- Advanced Glycation End Products research
- Chemical Synthesis and Reactions
Zhangjiakou Academy of Agricultural Sciences
2025
Nanchang University
2014-2024
Jiangxi Provincial Academy of Medical Sciences
2024
Hainan Medical University
2024
Second Affiliated Hospital of Nanchang University
2014-2024
Gansu University of Traditional Chinese Medicine
2024
Weatherford College
2024
Jiangxi Mental Health Center
2024
Zhongnan Hospital of Wuhan University
2022
Wuhan University
2022
Thoracic radiotherapy patients have higher risks of developing radiation-induced heart disease (RIHD). Ionizing radiation generates excessive reactive oxygens species (ROS) causing oxidative stress, while Momordica. charantia and its extract antioxidant activity. Plant-derived extracellular vesicles (EVs) is emerging as novel therapeutic agent. Therefore, we explored the protective effects -derived EVs-like nanovesicles (MCELNs) against RIHD. Using density gradient centrifugation,...
Abstract Background Doxorubicin (DOX) is a first-line chemotherapeutic drug for various malignancies that causes cardiotoxicity. Plant-derived exosome-like nanovesicles (P-ELNs) are growing as novel therapeutic agents. Here, we investigated the protective effects in DOX cardiotoxicity of ELNs from Momordica charantia L. (MC-ELNs), medicinal plant with antioxidant activity. Results We isolated MC-ELNs using ultracentrifugation and characterized them canonical mammalian extracellular vesicles...
Chronic kidney disease (CKD) lacks effective treatments and renal fibrosis (RF) is one of CKD's outcomes. Dickkopf 3 (DKK3) has been identified as an agonist in CKD. However, the underlying mechanisms DKK3 CKD are not fully understood.
Abstract Vascular calcification (VC) plays as a critical role on cardiovascular disease (CVD) and acts notable risk factor in system. smooth muscle cells (VSMCs) can be triggered by high phosphate treatment; however, the explicit mechanism remains unclear. In present study, we isolated VSMCs from primary rat artery, applied β‐GP (β‐glycerophosphate) for inducing vitro to explore of phosphate‐induced VSMCs. Alizarin red staining was performed assess mineralization Calcium deposition...
Abstract Background Functional electrospun membranes are promising dressings for promoting wound healing. However, their microstructure and drug loading capacity need further improvements. It is the first time to design a novel mesh-like fiber loaded with atorvastatin (ATV) investigated its effects on paracrine secretion by bone marrow-derived mesenchymal stem cells (BMSCs) healing in vivo. Methods We fabricated membrane using copper mesh receiver. The physical properties of were evaluated...
Renal fibrosis is the final pathway for chronic kidney disease to end-stage renal failure. Noncoding RNAs have been reported play a crucial role in fibrosis. Here, effects of long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) and miR-31 on their regulatory mechanism were evaluated. RT-qPCR was used assess NEAT1, miR-31, RhoA levels. Western blot performed analyze expression markers, RhoA, rho-related kinase (ROCK1), connective tissue growth factor (CTGF)....
Sexual dysfunction, particularly in females, is a complex issue influenced by various factors, including depression and inflammation. The Systemic immune-inflammation index (SII), an inflammatory biomarker, has shown associations with different health conditions, but its relationship female sexual dysfunction (FSD) remains unclear. This study aimed to investigate the association between SII FSD context of depression, utilizing low frequency as assessment indicator. Data from National Health...
Dendritic cell-associated C-type lectin-1 (Dectin-1), a lectin receptor, serves critical role in host antifungal immunity. However, the molecular mechanism and function of Dectin-1-mediated signaling response to infection by pathogenic fungus Talaromyces marneffei remains unclear. To understand Dectin-1 against T. infection, phosphorylation spleen tyrosine kinase (Syk), nuclear factor κ light polypeptide gene enhancer B-cells inhibitor, α (IκBα) NF-κB were analyzed using western blotting,...
Abstract BACKGROUND Rnd3, a small Rho-GTPase, is involved in various cardiovascular diseases, but its role diabetes-induced cardiomyocyte senescence unclear. This study aims to investigate the of Rnd3 diabetes cardiomyopathy (DCM). METHODS expression was assessed human tissue using qPCR, and correlation with clinical parameters analyzed. Senescence-associated secretory phenotype (SASP)-related marker determined heart from juvenile/mature mice streptozotocin-induced diabetic Sprague–Dawley...
An efficient synthesis of α-carbonyl-α'-sulfenyl sulfoxonium ylides through a KIO
Abstract This study explores the molecular role of BTK gene in lung adenocarcinoma (LUAD) progression and patient prognosis. Using a radiomics model based on expression PET‐CT data analyzed through DeeplabV3, alongside transcriptomic clinical from TCGA, we established strong predictive relationship between levels LUAD outcomes. Our findings demonstrate that low is linked to poorer prognoses. Experimental models, including cell lines vivo mouse studies, revealed deficiency leads increased...