A5100356873- Pharmacological Effects of Natural Compounds
- Medicinal Plant Pharmacodynamics Research
- Nonlinear Optical Materials Research
- Luminescence and Fluorescent Materials
- Ginseng Biological Effects and Applications
- Synthesis and Properties of Aromatic Compounds
- Glycosylation and Glycoproteins Research
- Mesenchymal stem cell research
- Perovskite Materials and Applications
- Metabolomics and Mass Spectrometry Studies
- Phytochemistry and Biological Activities
- Lipid metabolism and disorders
- Cancer Cells and Metastasis
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet, Metabolism, and Disease
- MicroRNA in disease regulation
- Axial and Atropisomeric Chirality Synthesis
- Traditional Chinese Medicine Analysis
- Cholesterol and Lipid Metabolism
- Lipoproteins and Cardiovascular Health
- Computational Drug Discovery Methods
- Toxin Mechanisms and Immunotoxins
- Acute Myeloid Leukemia Research
- Porphyrin and Phthalocyanine Chemistry
- Genomics, phytochemicals, and oxidative stress
Nankai University
2018-2025
University of Science and Technology of China
2024-2025
Kunming Medical University
2025
Materials Science & Engineering
2025
First Affiliated Hospital of Kunming Medical University
2025
Tongji Hospital
2020-2024
Huazhong University of Science and Technology
2020-2024
Xi’an Children’s Hospital
2024
Chinese Academy of Sciences
2024
South China Agricultural University
2023-2024
Flexible crystals have gained significant attention owing to their remarkable pliability, plasticity, and adaptability, making them highly popular in various research application fields. The main challenges developing flexible lie the rational design, preparation, performance optimization of such crystals. Therefore, a comprehensive understanding fundamental origins crystal flexibility is crucial for establishing evaluation criteria design principles. This Perspective offers retrospective...
The chirality-dependent lattice distortion assisted by a crown ether leads to an intense STEs emission along with CPL. distinct endows the Sb halides multi-stimuli-responsive PL behaviours towards excitation wavelength and temperature.
Flexible molecular crystals are essential for advancing smart materials, providing unique functionality and adaptability applications in next-generation electronics, pharmaceuticals, energy storage. However, the optical of flexible have been largely restricted to linear optics, with nonlinear (NLO) properties rarely explored. Herein, we report on application mechanical twisting second-order optics. The crystal formed through self-assembly model compound 9-anthraldehyde (AA) features an...
// Shicong Zhu 1, * , Zhihua Wang Zijian Li 2 Hongling Peng 1 Yunya Luo Mingyang Deng Ruijuan Chongwen Dai Yunxiao Xu Sufang Liu Guangsen Zhang Division of Hematology, Institute Molecular The Second Xiang-ya Hospital, Central South University, Changsha, Hunan, China First Affiliated Lanzhou Lanzhou, Gansu, These authors have contributed equally to this work Corresponding to: Zhang, e-mail: zgsllzy@163.com Keywords: icaritin, multiple myeloma, antitumor activities, IL6/JAK2/STAT3 signaling...
Lycium barbarum polysaccharide (LBP) is a substance with various biological activities extracted from barbarum. LbGPs are peptidoglycans short peptide backbone and complex, branched glycan moiety, which further isolated LBPs. Previous studies have shown that LbGP can inhibit cancer cell growth, but its specific mechanism not completely clear. In this study, we found could the proliferation of glioma cells promote expression period 2 (PER2) through PKA-CREB pathway. addition, de novo...
The high glucose uptake and activation of oncogenic signaling pathways in cancer cells has long made these features, together with the mutational spectrum, prime diagnostic targets circulating tumor (CTCs). Further, an ability to characterize properties at a single cell resolution is widely believed be essential, as known extensive heterogeneity CTCs can obscure important correlations data obtained from population-based methods. However, date, it not been possible quantitatively measure...
Abstract The nucleoprotein (NP) of Ebola virus (EBOV) and Marburg (MARV) is an essential component the viral ribonucleoprotein complex significantly impacts replication transcription RNA genome. Although NP regarded as a promising antiviral druggable target, no chemical ligands have been reported to interact with EBOV or MARV NP. We identified two compounds from traditional Chinese medicine Gancao (licorice root) that can bind both NPs by combining affinity mass spectrometry metabolomics...
Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disorder in gastrointestinal tract. Shen Ling Bai Zhu San (SLBZS), which has long history of use Traditional Chinese Medicine (TCM), been widely used to treat diseases. The isolated fractions TCM have also proved possess an important potential for treating diseases, are due their effective components.In this study, we examined the possibility that SLBZS its active may prevent DSS-induced colitis, investigated mechanisms...
Dynamic twisting crystals, combining the features of dynamic crystals and promise advanced applications in targeted drug delivery, biosensors, microrobots, spiral optoelectronics. However, determination with specific directions remains a formidable challenge practical applications. Herein, based on organic-inorganic hybrid metal halide (OIHMH) single we have realized chirality-induced macroscopic driven by thermo-induced topochemical dehydration reaction. These exhibit...
Background: Cardiovascular diseases (CVD) are a major global health issue strongly associated with altered lipid metabolism. However, metabolism-related pharmacological targets remain limited, leaving the therapeutic challenge of residual lipid-associated cardiovascular risk. The purpose this study is to identify potentially novel genes by systematic genomic and phenomics analysis, an aim discovering new diagnosis biomarkers for CVD. Methods: In study, we conducted comprehensive...
The A‐site organic components of organic‐inorganic hybrid metal halides (OIHMHs) significantly impact their crystal structure and optoelectronic properties. However, chemical modification cations has been mostly limited to commercial precursors, which restricts the structural variability OIHMHs for optimal functionalities. Herein we have proposed an extendable synthesis approach direct procurability various with desireable structures in situ construction a library OIHMH materials. template...
The A‐site organic components of organic‐inorganic hybrid metal halides (OIHMHs) significantly impact their crystal structure and optoelectronic properties. However, chemical modification cations has been mostly limited to commercial precursors, which restricts the structural variability OIHMHs for optimal functionalities. Herein we have proposed an extendable synthesis approach direct procurability various with desireable structures in situ construction a library OIHMH materials. template...
Adaptive crystals have attracted significant attention from solid-state chemists and crystal engineers for their promising applications in memories, capacitors, sensors, actuators. Among them, thermosalient are particularly favored thanks to efficient energy conversions rapid responses. However, the mechanisms mechanical responses of remain largely unclear. Herein we demonstrate that effects molecular could be driven by thermoelastic twisting behaviors. The crystal, based on a model compound...
Dynamic organic crystals are becoming recognized as some of the fastest materials for converting light or heat to mechanical work. The degree deformation and response time any actuating material often exclusive each other; however, both factors influence material's overall performance limits. Unlike polymers, whose disordered structures not conducive rapid energy transfer, cooperative phase transitions in dynamic molecular that amenable concerted martensitic-like structure switching could...
Osteoporosis, which is a prevalent metabolic bone disease, closely associated with imbalances in the gut microbiota. The ovaries of female 6-month-old Sprague-Dawley rats were surgically removed to induce osteoporosis. Subsequently, 16S rRNA sequencing was employed characterize microbiota osteoporotic rats. Bone marrow mesenchymal stem cells (BMSCs) isolated from and cultured separately, their osteogenic adipogenic differentiation observed. Furthermore, exosomes extracted these cells, miRNA...
Obesity is a debilitating global pandemic with huge cost on health care due to it being major underlying risk factor for several diseases. Therefore, there an unmet medical need pharmacological interventions curb obesity. Here, we report that halofuginone, Food and Drug Administration–approved anti-scleroderma antiprotozoal drug, promising anti-obesity agent in preclinical mouse pig models. Halofuginone suppressed food intake, increased energy expenditure, resulted weight loss diet-induced...
Background: To assess the effect of low-molecular-weight heparin (LMWH) combined with evoked potentials somatosensory potential (SEP) on prevention deep vein thrombosis (DVT) in patients undergoing spinal surgery. Methods: One hundred twenty-eight who underwent surgery from August 2022 to 2023 were chosen, and randomly classified into control group observation group, 64 cases each group. The received LMWH injections.The SEP monitoring basis blood flow velocity popliteal veins both lower...
Background/Aims: Arctigenin (ATG) has been shown to possess anti-inflammatory, immunemodulatory, anti-viral, anti-microbial, anti-carcinogenic, vasodilatory and anti-platelet aggregation properties. However, the protective role of ATG in prevention arrhythmias induced by myocardial ischemia/reperfusion is unknown. The aim this study was investigate anti-arrhythmia effect an injured rat heart model explore related mechanisms. Methods: Rats were randomly exposed sham operation, ischemia/...
The objective of this study was to investigate whether radical surgical treatment can be associated with reasonable survival for patients Stage IV gallbladder cancer distant lymph node metastasis.Fifty-five (20 men and 35 women) complete clinical follow-up data Japanese Society Biliary Surgery TNM system were included in our study. Patients divided into three groups analysis: Group A (radical resection, n = 24), B (chemotherapy, 8) C (other palliative treatment, 23).The rate significantly...
Although natural herbs have been a rich source of compounds for drug discovery, identification bioactive components from suffers low efficiency and prohibitive cost the conventional bioassay-based screening platforms. Here we develop new strategy that integrates virtual screening, affinity mass spectrometry (MS) targeted metabolomics efficient discovery herb-derived ligands towards specific protein target site. Herb-based conveniently selects potential bioactivity whereas MS combined with...