A5101994551- Manufacturing Process and Optimization
- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Phytochemical Studies and Bioactivities
- Advanced Numerical Analysis Techniques
- Composite Structure Analysis and Optimization
- Injection Molding Process and Properties
- Assembly Line Balancing Optimization
- Topology Optimization in Engineering
- Flexible and Reconfigurable Manufacturing Systems
- Advanced machining processes and optimization
- Traditional Chinese Medicine Analysis
- Advanced Machining and Optimization Techniques
- Electric Motor Design and Analysis
- Microbial Community Ecology and Physiology
- Soft Robotics and Applications
- Numerical methods in engineering
- Mitochondrial Function and Pathology
- Non-Destructive Testing Techniques
- Phytochemistry and Bioactive Compounds
- Tryptophan and brain disorders
- Genomics, phytochemicals, and oxidative stress
- Phytochemistry and Biological Activities
- Heat shock proteins research
- Sirtuins and Resveratrol in Medicine
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2024
Sun Yat-sen University
2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2024
Huazhong University of Science and Technology
1994-2022
Nankai University
2019-2021
State Key Laboratory of Medicinal Chemical Biology
2019-2021
Maastricht University
2019-2021
Tianjin University of Traditional Chinese Medicine
2020
Macau University of Science and Technology
2020
Nanjing University of Aeronautics and Astronautics
2020
Swertiamarin (SW), a representative component in Flos Lonicerae Japonicae , has been reported to exert significant activity preventing infections. In this research, we aim clarify the details of SW and its target explore SW's underlying anti‐inflammatory mechanisms. An azide labeled probe was synthesized for protein fishing, results demonstrated that AKT could be captured specifically. Immunofluorescence colocalization with implemented by click reaction alkynyl CY5. The result showed one...
Although the tumor suppressor P53 is known to regulate a broad network of signaling pathways, it still unclear how certain drugs influence these networks. Here, we used comprehensive single-cell multiomics view effects ginsenosides on cancer cells. Transcriptome and proteome profiling revealed that antitumor activity closely associated with protein. A miRNA-proteome interaction controlled transcription at least 38 proteins, proteome-metabolome analysis regulated proteins involved in...
With the advent of mass customisation, solving assembly sequence planning (ASP) problem not only involves a non-convex optimisation that is hard to solve but also requires high-speed response changes resources. This paper proposes deep reinforcement learning (DRL) approach for ASP problem, aiming at promoting speed by exploiting reusability and expandability past decision-making experiences. First, connector-based described in matrix manner, its objective function set minimise cost under...
Platycodon grandiflorum, as a traditional medicinal plant, is commonly used in the treatment of pulmonary disease. saponins are proposed active ingredients. However, role secondary saponin metabolites (SSM) use has not yet been fully clarified. In this study, [18F]-phillygenin ([18F]-PH) probe was synthesized and thereby tracer for micro-positron emission tomography scanning to explore effects platycodon saponins. The membrane permeability with different SSM evaluated vitro based on dye...
The control performance of a butterfly-shaped linear ultrasonic motor is not good when the target speed less than 1 mm/s by traditional methods.To improve low-speed controlling characteristics motor, closed-loop strategy using both step and fuzzy PID was proposed.The controller constructed with function providing adjusting driving voltage amplitude in stepping mode.The corresponding parameters were determined experiments.Comprehensive experiments on developed conducted under different...
The magnetic field in a DC permanent magnet coreless disc machine is studied depth by using different methods, such as three dimensional finite element method (3DFEM), two (2DFEM) and circuit (MCM) based on an analytical solution. For optimization, the cases for dimensions, airgap lengths configurations are investigated detail. Numerical results show that if provided ferrite magnets, ratio of thickness to length should be greater than 3 distance from stator wall or width magnetism-free...
Feature interactions may result in many process alternatives part machining. Traditional planning methods only identify one of the options, which is usually not optimal sense engineering. This paper presents an optimisation approach to handle interacting feature recognition problem mill-turn parts. The subdivides material removal volume into cells first and then it combines features. Here, a two-level cell combination method developed. On lower level, individual features are formed by...
Supplementation with nicotinamide adenine dinucleotide (NAD+) precursors including dietary has been found to boost tissue NAD+ levels and ameliorate oxidative stress-induced damage that contributes aging aging-related diseases. The association between patient-reported health-related outcomes in cancer survivors not investigated. This study aimed determine associations of intake different colorectal survivors, 2 10 years post-diagnosis. A total 145 eligible participants were recruited into...
In the Antarctic marine ecosystem, krill play a pivotal role, yet intricate microbial community intertwined with these diminutive crustaceans remains largely unmapped. this study, we successfully isolated and characterized unique bacterial strain, Pseudoalteromonas sp. WY3, from krill. Genomic analysis revealed that WY3 harbors multitude of genes associated cold shock proteins, oxidoreductases, enzymes involved in osmotic stress response, equipping it robust molecular arsenal to withstand...
Abstract The computation cost of matrix formation in isogeometric analysis can be drastically reduced by employing tensor decomposition, but the performance like accuracy and robustness still depends on approach used to realize low‐rank approximation for nonpolynomial integral kernels. In buckling laminated shells with solid‐shell model, kernels are not smooth thickness direction due their material stress distribution have a high complexity because curvilinear coordinate systems involved...
Computer-aided process planning (CAPP) plays an important role in integrated manufacturing system and it can serve as a bridge between CAD CAM. As crucial part of CAPP, setup is multi-constraint problem, which the precision takes priority over efficiency. However, instead constraints, traditional optimization methods have paid much more attention to efficiency requirements. This leads reduction final parts. paper develops approach for solving computer-aided into account various especially...
Maintaining the continuity (blending) of stacking sequences is very vital when a multi-region panel being optimized. The traditional attempt simplifies difficulty blending problem by designing whole based on one template. However, this simplification adds an unnecessary constraint that regions with same thickness should have sequence. In order to overcome drawback, paper introduces region block queue method obtain optimal manufacturable composite laminates blended from multiple templates....
Abstract Background: Nanoparticle-based pulmonary drug delivery systems are commonly developed and applied for drug-targeted delivery. It exhibits significant advantages compared to traditional systems. However, developing a formulation each is time-consuming laborious task. Results: This study designed constructed universal lung-targeting nanoparticle. The self-assembled micelles were composed of platycodon secondary saponin, 3-O-β-D-glucopyranosyl platycodigenin 682 (GP-682), via its...
Abstract Background: Nanoparticle-based pulmonary drug delivery systems are commonly developed and applied for drug-targeted delivery. It exhibits significant advantages compared to traditional systems. However, developing a formulation each is time-consuming laborious task. Results: The present study designed constructed universal lung-targeting nanoparticle. self-assembled micelles were composed of platycodon secondary saponin, 3-O-β-D-glucopyranosyl platycodigenin 682 (GP-682), via its...
Abstract Background: Nanoparticle-based pulmonary drug delivery systems are commonly developed and applied for drug-targeted delivery. They exhibit significant advantages compared to traditional systems. However, developing the formulation of each is a time-consuming laborious task. Results: In this study, universal lung-targeting nanoparticle was designed constructed. The self-assembled micelles were composed platycodon secondary saponin, 3-O-β-D-glucopyranosyl platycodigenin 682 (GP-682),...