A5069303110- Gut microbiota and health
- Animal Nutrition and Physiology
- Pharmacological Effects of Natural Compounds
- Mycotoxins in Agriculture and Food
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Studies
- Diet and metabolism studies
- Herbal Medicine Research Studies
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
- Natural product bioactivities and synthesis
- Clostridium difficile and Clostridium perfringens research
- Selenium in Biological Systems
- Effects of Environmental Stressors on Livestock
- Tryptophan and brain disorders
- Phytochemistry and Biological Activities
- Bee Products Chemical Analysis
- Ginger and Zingiberaceae research
- Inflammatory Bowel Disease
- Agriculture and Biological Studies
- Circadian rhythm and melatonin
- Toxin Mechanisms and Immunotoxins
- Food Quality and Safety Studies
- Biochemical effects in animals
- Inflammasome and immune disorders
South China Agricultural University
2016-2025
Key Laboratory of Guangdong Province
2021-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2022-2024
Guangdong Provincial Center for Disease Control and Prevention
2022
Gut microbiota** play important roles in the health and disease status of both humans animals. Little is known about whether heat stress changes composition gut microbiota chicken. The aim this study was to investigate effects on caecal microbiota, including growth performance as well HSP70 cortisol levels. Sixty 14-day-old female broilers were equally divided into 2 treatment groups with different housing temperatures for 28 D: a control group (C) at 24 26°C (HS) 34 38°C. contents broiler...
This study systematically evaluated the effect of Forsythia suspensa extract on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) and determined its mechanism action. The results showed that significantly inhibited DSS-induced UC in mice. In vivo mechanistic studies revealed relieved symptoms by enhancing antioxidant activity inhibiting pyroptosis. Further vitro experiments it reduced level reactive oxygen species (ROS) J774A.1 cells. We found enhanced cellular antioxidation After...
There is a bidirectional relationship between inflammatory bowel disease (IBD) and depression/anxiety. Emerging evidences indicate that the liver may be involved in microbiota-gut-brain axis. This experiment focused on role of melatonin regulating gut microbiota explores its mechanism dextran sulphate sodium- (DSS-) induced neuroinflammation injury. Long-term DSS-treatment increased lipopolysaccharide (LPS), proinflammation cytokines IL-1 β TNF- α , leak rats, breaking blood-brain barrier...
The traditional Chinese medicine Shen-ling-bai-zhu-san (SLBZS) is described in "Tai Ping Hui Min He Ji Ju Fang." SLBZS has been shown to be effective against many gastrointestinal diseases. present study aimed investigate the effect of on experimental colitis mice and define potential mechanisms. Our data suggest that compared model group, treatment increases mouse body weight colon length, decreases DAI score, improves colonic injury. reduces production cytokines (IL-1β, IL-18, TNF-α)...
This study aimed to investigate the effects of polyherbal mixtures (PHM) on growth performance, antioxidant capacities, immune function, and intestinal health in yellow-feathered broilers. PHM is composed five traditional Chinese medicine herbs (Portulaca oleracea L., Radix Sophora flavescens, Thalictrum glandulosissimum, Terra flava usta, Pogostemon cablin). A total 270 one-day-old broilers were randomly allotted into 3 treatments for a 42-d feeding trial, each with 6 replicates 15 birds....
Generally, depression is the result of complex gene-environment interactions. Recent studies have showed that gut microbiota can affect brain function through microbiota-gut-brain axis. However, underlying mechanism and potential influence remain elusive. We aimed to determine how microbiome contributes process further influences host. Chronic unpredictable mild stress (CUMS) used establish a model. Fecal transplant (FMT) applied illustrate be transmitted via microbiota, metabolism liver...
Echinacea purpurea (L.) Moench (EP) is a perennial herbaceous flowering plant, commonly known as purple conical flower. It was widely used to treat skin inflammation and gastrointestinal diseases.Ulcerative colitis (UC) chronic nonspecific inflammatory disease. Recent evidence shows that immune disorders are involved in the pathogenesis of UC. To evaluate protective effect exact (EE) on UC explore role complement system treatment UC.UC model induced rats by 2,4,6-trinitrobenzene sulfonic...
Inflammatory bowel disease (IBD) is a chronic and recurrent inflammatory disorder in gastrointestinal tract. Shen Ling Bai Zhu San (SLBZS), which has long history of use Traditional Chinese Medicine (TCM), been widely used to treat diseases. The isolated fractions TCM have also proved possess an important potential for treating diseases, are due their effective components.In this study, we examined the possibility that SLBZS its active may prevent DSS-induced colitis, investigated mechanisms...
Chichoric acid (CA) is a major active ingredient found in chicory and Echinacea. As derivative of caffeic acid, it has various pharmacological effects. Due to the unclear etiology disease mechanisms, effective treatment methods for ulcerative colitis (UC) are currently lacking. The study investigated therapeutic effects folate-chicory liposome on both LPS-induced macrophage inflammation models dextran sulfate sodium (DSS)-induced mouse UC models. Folate-chicory was prepared using double...
Chinese herbs have been used as feed additives and are commonly utilized in domestic intensive livestock farming. However, their impact on the production performance intestinal health of broiler breeders has yet to be thoroughly explored. This study aimed evaluate effects a herbal mixture (CHM) terms reproductive hormones, antioxidant capacity, immunity, breeders. A total 336 thirty-wk-old hens were randomly allotted 4 groups with 6 replicates fourteen each, which fed basal diet supplemented...
As the world warms up, heat stress is becoming a major cause of economic loss in livestock industry. Long-time exposure animals to hyperthermia causes extensive cell apoptosis, which harmful them. AKT and AKT-related serine–threonine kinases are known be involved signaling cascades that regulate survival, but mechanism remains elusive. In present study, we demonstrate phosphoinositide 3-kinase (PI3K) /AKT signal pathway provides protection against apoptosis induced by ascertain key point for...
Atopic dermatitis (AD) is a common chronic allergic skin disease characterized clinically by severe lesions and pruritus. Portulaca oleracea L. (PO) resourceful plant with homologous properties in medicine food. In this study, we used two different methods to extract PO, compared the therapeutic effects of PO aqueous (POAE) ultrasound-assisted ethanol (POEE) on 2,4-dinitrochlorobenzene (DNCB)-induced AD mice. The results showed that POAE POEE, extraction rates polysaccharides were 16.95%...
Phytosterols (PS) have been shown to regulate cholesterol metabolism and alleviate hyperlipidemia (HLP), but the mechanism is still unclear. In this study, we investigated by which PS regulates in high-fat diet (HFD) mice. The results showed that treatment reduced accumulation of total (TC), triglycerides (TG), low-density lipoprotein (LDL-C) serum HFD mice, while increasing levels high-density (HDL-C). Compared with not only increased antioxidant activity liver also regulated mRNA...
Generally, inflammatory bowel disease (IBD) can be caused by psychology, genes, environment, and gut microbiota. Therefore, IBD therapy should improved to utilize multiple strategies. Shen Ling Bai Zhu San (SLBZS) adheres the aim of combating complex diseases from an integrative holistic perspective, which is effective for therapy. Herein, a systems pharmacology microbiota approach was developed these molecular mechanisms exemplified SLBZS. First, systematic...
This study aimed to explore the protective effect of sulfated Codonopsis polysaccharides (SCP) on acute oxidative stress. SCP was modified by chlorosulfonic acid-pyridine method from (CP), which had 34.48% sulfate content determined ultrasonic-acidic barium chromate spectrophotometry. The analysis Fourier transform-infrared spectroscopy (FT-IR) appeared an absorption peak at 811.91 cm−1, related C-O-SO3. In vitro test, antioxidant activities CP and induced H2O2 in RAW264.7 cells, results...
Heat stress (HS) in broilers can be an environmental stressor that leads to intestinal inflammation and barrier damage. In order examine the effect of Ban Lian Zi Jin San (BLZJS) on function heat stressed broilers, a model chronic cyclic HS broilrers was established. A total 300 21-day-old were divided into 5 treatments at random. Broilers three BLZJS dosage groups kept ecologically controlled room 37±2℃ for six weeks, fed basal diets supplemented with 0.5%, 1%, 2% BLZJS. group housed same...