A5078192964- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Sugarcane Cultivation and Processing
- RNA Research and Splicing
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Cancer-related gene regulation
- Plant Gene Expression Analysis
- Biofuel production and bioconversion
- Plant Pathogenic Bacteria Studies
- Hepatitis B Virus Studies
- Advanced Multi-Objective Optimization Algorithms
- VLSI and FPGA Design Techniques
- Carbon and Quantum Dots Applications
- Viral Infections and Outbreaks Research
- Cancer, Hypoxia, and Metabolism
- Plant-Microbe Interactions and Immunity
- Plant Disease Resistance and Genetics
- Nanocluster Synthesis and Applications
- Ultrasound and Hyperthermia Applications
- Extracellular vesicles in disease
- Chemical Safety and Risk Management
- Physiological and biochemical adaptations
- Protein purification and stability
- Neurogenetic and Muscular Disorders Research
Fujian Agriculture and Forestry University
2021-2024
Umeå University
2014-2024
Ministry of Agriculture and Rural Affairs
2021-2024
Lanzhou University
2014-2023
Lanzhou University Second Hospital
2014-2023
Fudan University
2009-2022
Case Western Reserve University
2022
Lanzhou City University
2020-2021
Dalian Ocean University
2019
Tianjin University of Science and Technology
2016
Wood has attracted increasing scientific interest in the field of green electronics, biological devices, bioenergy, and energy storage because its abundance, low cost, biocompatibility, natural vessel structure. However, potential application important area environmental monitoring not yet been effectively explored. In this work, gold nanoparticles (NPs) encapsulated porous wood (denoted as Au@wood) for high-performance colorimetric detection Hg2+ aqueous solution have constructed. The...
Sugarcane response to
Abstract The nucleoprotein (NP) of Ebola virus (EBOV) and Marburg (MARV) is an essential component the viral ribonucleoprotein complex significantly impacts replication transcription RNA genome. Although NP regarded as a promising antiviral druggable target, no chemical ligands have been reported to interact with EBOV or MARV NP. We identified two compounds from traditional Chinese medicine Gancao (licorice root) that can bind both NPs by combining affinity mass spectrometry metabolomics...
In plants, lysine acetylation (Kac), 2-hydroxyisobutyrylation (Khib), and lactylation (Kla), the three new types of post-translational modification (PTM), play very important roles in growth, development, resistance to adverse environmental stresses. Herein, we report first global acetylome, 2-hydroxyisobutyrylome, lactylome sugarcane. A total 8573 Kac, 4637 Khib, 215 Kla sites across 3903, 1507, 139 modified proteins were identified. Besides, homology analyses revealed on histones conserved...
A porous photosensitizer displaying catalase-like activity and drug synthesis ability was synthesized for the synergistic chemo-photodynamic therapy, opening new promising ways carrying out precise cooperative treatment of hypoxic tumors.
The synergistic nanotheranostics of reactive oxygen species (ROS) augment or phototherapy has been a promising method within oncotherapy. However, it is still hindered by sophisticated design and fabrication, lack multimodal effect, hypoxia-associated poor photodynamic therapy (PDT) efficacy. Herein, kind porous shuttle-shape platinum (IV) methylene blue (Mb) coordination polymer nanotheranostics-loaded 10-hydroxycamptothecin (CPT) fabricated to address the abovementioned limitations. Our...
A novel self-targeting theranostic nanoplatform was developed to deliver sonosensitizers for photoacoustic imaging-monitored and enhanced chemo-sonodynamic therapy.
Light-driven endogenous water oxidation has been considered as an attractive and desirable way to obtain O2 reactive oxygen species (ROS) in the hypoxic tumor microenvironment. However, use of a second near-infrared (NIR-II) light achieve H2O alleviate hypoxia realize deep phototherapy is still challenge. Herein, novel plasmonic Ag–AgCl@Au core–shell nanomushrooms (NMs) were synthesized by selective photodeposition Au at bulge sites Ag–AgCl nanocubes (NCs) under visible irradiation. Upon...
Objective. To investigate whether calcium‐sensing receptor (CaSR) plays a role in calcium‐oxalate‐induced renal injury. Materials and Methods. HK‐2 cells rats were treated with calcium oxalate (CaOx) crystals or without pretreatment the CaSR‐specific agonist gadolinium chloride (GdCl 3 ) antagonist NPS2390. Changes oxidative stress (OS) rat kidneys assessed. In addition, CaSR, extracellular signal‐regulated protein kinase (ERK), c‐Jun N‐terminal (JNK), p38 expression was determined. Further,...
The Elongator complex promotes formation of 5-methoxycarbonylmethyl (mcm5) and 5-carbamoylmethyl (ncm5) side-chains on uridines at the wobble position cytosolic eukaryotic tRNAs. In all organisms tested to date, inactivation not only leads lack mcm5/ncm5 groups in tRNAs, but also a wide variety additional phenotypes. Although phenotypes are most likely caused by translational defect induced reduced functionality hypomodified mechanism(s) underlying individual poorly understood. this study,...
Fu Xua, Xiuli Changa, Dan Loua, Qing Wua & Zhijun Zhou*aa School of Public Health/Key Laboratory for Health Safety MOE/WHO Collaborating Center Occupational (Shanghai), Fudan University, Shanghai, P. R. China
Sugarcane is an important sugar and bioenergy ethanol crop, the hyperploidy has led to stagnant progress in sugarcane genome decipherment, which also hindered genome-wide analyses of versatile lectin receptor kinases (LecRKs). The published Saccharum spontaneum, one two ancestor species, enables us study characterization LecRKs their responses leaf blight (SLB) triggered by Stagonospora tainanensis. A total 429 allelic non-allelic LecRKs, were classified into evolved independently three...
Highlights•SNAT2 activity mediates biphasic translational control in osmoadaptation•Early-phase stress inhibits translation and induces distinct RBP condensates•Late-phase SNAT2-mediated uptake of amino acids reverses inhibition•SNAT2 disassembles early-phase condensatesSummaryThe integrated response (ISR) plays a pivotal role adaptation machinery to cellular stress. Here, we demonstrate an ISR-independent osmoadaptation mechanism involving reprogramming via coordinated but independent...
Gretchen Hagen3 (GH3), one of the three major auxin-responsive gene families, is involved in hormone homeostasis vivo by amino acid splicing with free forms salicylic (SA), jasmonic (JA) or indole-3-acetic (IAA). Until now, functions sugarcane GH3 (SsGH3) family genes response to biotic stresses have been largely unknown. In this study, we performed a systematic identification SsGH3 at genome level and identified 41 members on 19 chromosomes wild species, Saccharum spontaneum. Many these...
Uridine residues present at the wobble position of eukaryotic cytosolic tRNAs often carry a 5-carbamoylmethyl (ncm 5 ), 5-methoxycarbonylmethyl (mcm or 5-methoxycarbonylhydroxymethyl (mchm ) side-chain. The presence these side-chains allows proper pairing with cognate codons, and they are particularly important in tRNA species where U 34 residue is also modified 2-thio (s 2 group. first step synthesis ncm , mcm mchm dependent on six-subunit Elongator complex, whereas thiolation 2-position...
Objectives In this study, we focused on the function of nuclear factor E2–related 2 (Nrf2) in acute pancreatitis (AP), which has been shown to have protective effects gliomas, hepatocytes, and astrocytes. Methods Acute cell line animal model were induced by administration lipopolysaccharide cerulein into supernatant or intraperitoneal injection. Oxidative stress status was evaluated measuring level amylase, C-reactive protein, malondialdehyde, superoxide dismutase, myeloperoxidase....
Mosaic viral diseases affect sugarcane productivity worldwide. Mining disease resistance-associated molecular markers or genes is a key component of resistance breeding programs. In the present study, 285 F1 progeny were produced from cross between Yuetang 93-159, moderately resistant variety, and ROC22, highly susceptible variety. The mosaic symptoms these progenies, with ROC22 as control, surveyed by natural infection under 11 different environmental conditions in field artificial...
A wide variety of factors are required for the conversion pre-tRNA molecules into mature tRNAs that function in translation. To identify influencing tRNA biogenesis, we previously performed a screen strains carrying mutations induce lethality when combined with sup61-T47:2C allele, encoding mutant form tRNACGASer. Analyzes two complementation groups led to identification Tan1 as protein involved formation modified nucleoside N4-acetylcytidine (ac4C) and Bud13 factor controlling levels ac4C...
On-demand drug release nanoplatforms are promising alternative strategies for enhancing the therapeutic effect of cancer chemotherapy. However, these still have many drawbacks including rapid blood clearance, nontargeted specificity, and a lack immune escape function. Even worse, they also hindered via dosage-limiting toxicity traditional chemotherapeutic drugs. Herein, both dual-functional mannose (enhances antitumor activity drugs exhibits an innate affinity against lectin receptor)...