A5066298687- Heavy Metal Exposure and Toxicity
- Paraquat toxicity studies and treatments
- Effects and risks of endocrine disrupting chemicals
- Pesticide Exposure and Toxicity
- Birth, Development, and Health
- Trace Elements in Health
- Carcinogens and Genotoxicity Assessment
- Per- and polyfluoroalkyl substances research
- Health, Environment, Cognitive Aging
- Neurogenesis and neuroplasticity mechanisms
- Toxic Organic Pollutants Impact
- Peroxisome Proliferator-Activated Receptors
- Air Quality and Health Impacts
- Mercury impact and mitigation studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Pesticide and Herbicide Environmental Studies
- Electron Spin Resonance Studies
- Anesthesia and Neurotoxicity Research
- Sperm and Testicular Function
- Heavy metals in environment
- Mitochondrial Function and Pathology
- Gestational Diabetes Research and Management
- Pregnancy and Medication Impact
- Selenium in Biological Systems
- Genetic Associations and Epidemiology
Fudan University
2015-2024
Shanghai Medical College of Fudan University
2021-2024
National Health and Family Planning Commission
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2018
Ministry of Education of the People's Republic of China
2017
Fudan University Shanghai Cancer Center
2016
Shanghai Public Health Clinical Center
2014
Karolinska Institutet
2009
Prenatal exposure to heavy metals, pesticides and phenols has been suggested interfere with neurodevelopment, but the neurotoxicity of their mixtures is still unclear. We aimed elucidate associations maternal urinary concentrations selected chemical intelligence quotient (IQ) in children. Maternal pesticide metabolites, were quantified pregnant women who participated Sheyang Mini Birth Cohort Study (SMBCS) from June 2009 January 2010. At age 7 years, child's IQ score was assessed using...
Prenatal exposure to organophosphorous (OP) pesticides has been found be associated with adverse effects on child neurodevelopment, but evidence potential induced by both prenatal and postnatal OP in infants is limited.Our aim was investigate the associations of birth outcomes infant neurodevelopment.Exposure 310 mother-infant pairs assessed measuring dimethylphosphate (DM), diethylphosphate (DE), total dialkylphosphate (DAP) metabolites urines from pregnant women their children at 2 years...
Compelling evidences have shown that diverse environmental insults arising during early life can either directly lead to a reduction in the number of dopaminergic neurons or cause an increased susceptibility degeneration with subsequent aging alone. Oxidative stress is considered main effect neurotoxins exposure. In this study, we investigated oxidative Paraquat (PQ) on immortalized human embryonic neural progenitor cells by treating them various concentrations PQ. We show PQ decrease...
Abstract Growing evidence suggests abnormalities of brain structural connectome in psychiatric disorders, but the causal relationships remain underexplored. We conducted bidirectional two-sample Mendelian randomization (MR) analyses to investigate links between 206 white-matter connectivity phenotypes (n = 26,333, UK Biobank) and 13 major disorders 14,307 1,222,882). Forward MR identified effects genetically predicted five on six with associations being significant or suggestive. For...
// Di Jin 1* , Jun Tao 2* Dan Li 3 Yanan Wang 2 Zhongdong Hu 4 Zhenzhen Zhou 5 Xiuli Chang 6 Chunfeng Qu and Hongbing Zhang 1,2 1 Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China State Key Laboratory Molecular Biology, Department Physiology, Basic Sciences, Chinese Academy Sciences Peking Union College, Beijing, Cell Engineering Research Center, Modern Center for Traditional Medicine, Beijing University Oncology, Institute/Hospital, * These authors have contributed...
Recent studies have suggested a critical role for toll-like receptor 4 (TLR4) in the development of alcoholic liver disease. As TLR4 is widely expressed throughout body, it unclear which TLR4-expressing cell types contribute to alcohol-induced damage. We selectively ablated hepatocytes and myeloid cells. Male mice were fed liquid diet containing either 5% alcohol or pair-fed control weeks examine chronic intake-induced damage inflammation. In addition, administered single oral gavage...
Higher melamine exposure may increase the risk of kidney stone formation and injury in infants, but little is known about potential nephrotoxic effects environmental low-dose its derivative on function adults general population. Our objective was to assess associations between urinary concentrations derivative, cyanuric acid, through analyzing data from National Health Nutrition Examination Survey (NHANES) 2003–2004. Information 298 participants aged ≥20 years utilized. Urinary acid levels...
Flurochloridone (FLC), a selective herbicide used on global scale, has been reported to have male reproductive toxicity which underlying mechanism is still largely unknown. The present study was conducted determine the effects of FLC Sertoli cell and explore its by using normal mouse (TM4) line. Our data indicate that suppressed proliferation TM4 cells in dose- time-dependent manner. Further studies confirmed induced apoptosis cells, accompanied reactive oxygen species (ROS) accumulation,...
Fluorochloridone (FLC), a selective pyrrolidone herbicide, has been recognized as potential endocrine disruptor and reported to induce male reproductive toxicity, but the underlying mechanism is unclear. The aim of this study was investigate FLC-induced toxicity on mice with particular emphasis role autophagy in mice' TM4 Sertoli cells.Adult C57BL/6 were divided into one control group (0.5% sodium carboxymethyl cellulose), four FLC-treated groups (3,15,75,375 mg/kg). animals (ten per group)...
Per- and polyfluoroalkyl substances (PFAS) have been suspected as potential environmental obesogens, with several mechanisms being proposed, including the role of metabolomics. However, current epidemiological studies yielded inconclusive findings.