A5100361318- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Protease and Inhibitor Mechanisms
- Colorectal Cancer Screening and Detection
- Cancer Mechanisms and Therapy
- Cardiac Structural Anomalies and Repair
- Genetic factors in colorectal cancer
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatic and Hepatic Oncology Research
- Radiopharmaceutical Chemistry and Applications
- Neuropeptides and Animal Physiology
- Colorectal Cancer Treatments and Studies
- Microbial Natural Products and Biosynthesis
- Drug Transport and Resistance Mechanisms
- Gastric Cancer Management and Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Esophageal Cancer Research and Treatment
- Psoriasis: Treatment and Pathogenesis
- Liver Diseases and Immunity
- Wnt/β-catenin signaling in development and cancer
- Brain Metastases and Treatment
Peking University International Hospital
2024
Sentara Norfolk General Hospital
2024
Thomas Jefferson University Hospital
2024
Shandong First Medical University
2023-2024
Shandong Tumor Hospital
2023-2024
Academy of Medical Sciences
2024
Hainan Medical University
2024
Peking University
2024
Zhejiang Hospital
2024
Bristol-Myers Squibb (United States)
2018-2023
Background: In this study, we evaluated the 8th edition of Union for International Cancer Control (UICC)/AJCC staging system nasopharyngeal carcinoma (NPC) in an endemic area, with aim validating its applicability and providing further information future refinements. Methods: A total 1,790 patients newly diagnosed, non-distant metastatic, histologically proven NPC treated intensity-modulated radiotherapy (IMRT) were retrospectively reviewed. The performance various systems was compared using...
In recent years, fibroblast activation protein (FAP) has emerged as an attractive target for the diagnosis and radiotherapy of cancers using FAP-specific radioligands. Herein, we aimed to design a novel 18F-labeled FAP tracer ([18F]AlF-P-FAPI) imaging evaluated its potential clinical application. The [18F]AlF-P-FAPI was prepared in automated manner within 42 min with non-decay corrected radiochemical yield 32 ± 6% (n = 8). Among A549-FAP cells, demonstrated specific uptake, rapid...
To investigate the target delivery properties of RC48-ADC, a novel antibody drug conjugate (ADC) comprising cytotoxic monomethyl auristatin E (MMAE) and an anti-human epidermal growth factor receptor 2 (HER2) tethered via valine-citrulline linker, in vitro vivo.Dissociation rate MMAE from RC48-ADC was used as estimate its stability serum. Cytotoxicity towards multiple cell lines measured. Subcellular distribution determined by fluorescence imaging. The mechanism lysosome targeting verified....
Due to tumor heterogeneity and complex tumor-stromal interactions in multicellular systems, the efficiency of monospecific tracers for diagnosis therapy is currently limited. In light evidence prostate-specific membrane antigen (PSMA) overexpression cells fibroblast activation protein (FAP) upregulation stroma, heterodimer dual targeting PSMA FAP may have potential improve diagnosis. Herein, we described radiosynthesis, vitro characterization, micro-PET/CT imaging two novel 18F-labeled...
The HER2 oncogene is overexpressed or amplified in 20% of breast cancers. HER2-positive cancer historically portends a poor prognosis, but the HER2-targeted therapy trastuzumab mitigates this otherwise ominous distinction. Nevertheless, some patients suffer disease recurrence despite trastuzumab, and metastatic remains largely incurable due to innate acquired resistance. Thus, understanding resistance an unmet medical need. Through RNA interference screening, we discovered that knockdown...
// Di Jin 1* , Jun Tao 2* Dan Li 3 Yanan Wang 2 Zhongdong Hu 4 Zhenzhen Zhou 5 Xiuli Chang 6 Chunfeng Qu and Hongbing Zhang 1,2 1 Institute of Cancer Stem Cell, Dalian Medical University, Dalian, China State Key Laboratory Molecular Biology, Department Physiology, Basic Sciences, Chinese Academy Sciences Peking Union College, Beijing, Cell Engineering Research Center, Modern Center for Traditional Medicine, Beijing University Oncology, Institute/Hospital, * These authors have contributed...
LBA8511 Background: Several studies have shown an association of pathological response, a common efficacy endpoint in neoadjuvant therapy trials, with survival for chemo various cancers including resectable NSCLC. However, the between complete response (pCR) and as well degree regression that may be predictive EFS immunotherapy has not been rigorously studied. CheckMate 816 (NCT02998528), randomized phase 3 study NIVO + vs NSCLC, met both its primary endpoints statistically significant...
Hpn is a small histidine-rich cytoplasmic protein from Helicobacter pylori and has been recognized as high-risk factor for several cancers including gastric cancer, colorectal MALT lymphoma. However, the relationship between remains elusive. In this study, we discovered that effectively suppressed cell growth induced apoptosis in hepatocellular carcinoma (HCC). A two-dimensional gel electrophoresis mass spectrometry-based comparative proteomics was performed to find molecular targets of HCC...
Abstract Background Exploring predictive biomarkers and therapeutic strategies of ICBs has become an urgent need in clinical practice. Increasing evidence shown that ARID1A deficiency might play a critical role sculpting tumor environments various tumors be used as pan-cancer for immunotherapy outcomes. The current study aims to explored the immune-modulating Hepatitis B virus (HBV) related hepatocellular carcinoma (HBV-HCC) its potential immunotherapeutic implications. Methods In study, we...
We examined CEACAM6, ITGB1, and cyr61 concentrations from patients with gastric cancers (GCs) to assess their clinical application for diagnosing monitoring diseases.Real-time reverse transcription-polymerase chain reaction was used detect the expressions of CEA, IGF1R, CK20, cyr61, S100A4 in peripheral blood karyocyte 82 GC, 24 recurrence, 37 healthy volunteers. Receiver operating characteristics (ROC) curves were constructed.There significant association between these TNM Stages distant...
Early B-lineage cells in mice express a cell surface glycoprotein, recognized by the BP-1 and 6C3 monoclonal antibodies, that has been identified as aminopeptidase A (APA E.C.3.4.11.7). In present studies we obtained evidence DNA "zoo-blot" analysis APA gene is highly conserved. This ectoenzyme catalyzes removal of N-terminal Glu- Asp-residues to convert angiotensin II III, degradation step important local regulation blood pressure mammals. To gain further insight into physiology this...
BACKGROUND Multitarget stool DNA (mt‐sDNA) is an approved method for colon cancer screening that especially relevant patients who cannot undergo colonoscopy. Although the test performance has been evaluated in a large clinical trial, it was limited to predominantly white population. Given differences epidemiology and biology of African American individuals, authors sought compare mt‐sDNA between racial groups. METHODS The prospectively identified aged ≥40 years were referred colonoscopy at...
Abstract Niclosamide is an antihelminthic drug. Recent studies show that niclosamide exerts antitumor activity through inhibiting multiple signals including Wnt/β‐catenin, mTORC1, signal transducer and activator of transcription 3, NF‐κB, notch signals; however, the insolubility poor bioavailability limits its potential clinic use, aim present work to synthesize injectable pegylated (polyethylene glycol‐modified niclosamide) investigate in vitro vivo. The (mPEG5000‐Nic) was synthesized...
Manumycin is a natural, well-tolerated microbial metabolite and regarded as farnesyltransferase inhibitor. Some data suggest that manumycin inhibits proliferation of diverse cancer cells through various pathways. However, the antitumor effect on colorectal (CRC) remains unknown. In present study, we investigated CRC in vitro vivo. The results cell viability assay revealed was significantly inhibited by manumycin. Moreover, apoptosis induced also found time- dose-dependent manner....
Abstract Background Neoadjuvant immunochemotherapy can effectively downstage tumors and reduce the risk of postoperative recurrence distant metastasis in patients with non‐small cell lung cancer (NSCLC). In this study, we investigated correlation between inflammatory biomarkers tertiary lymphoid structure (TLS) expression. We also compared predictive values these parameters, TLSs, a combination parameters TLSs for neoadjuvant efficacy NSCLC. Methods retrospectively analyzed clinical...
Abstract Pulmonary arterial hypertension (PAH) is a common complication of congenital heart disease (CHD). Deubiquitinase cylindromatosis (CYLD) has been reported to significantly aggravate vascular smooth muscle cell (VSMC) phenotypic transformation, proliferation, and migration. Here, we aimed further investigate its roles underlying mechanisms in the CHD‐PAH development. The expression CYLD lung tissues from patients monocrotaline (MCT) plus aortocaval (AV)‐induced PAH rats, pulmonary...
The unfolding and denaturation curves of potato carboxypeptidase inhibitor (PCI) were investigated using the technique disulfide scrambling. In presence denaturant thiol initiator, native PCI denatures by shuffling its bonds converts to form a mixture scrambled that consists 9 out possible 14 isomers. curve is determined fraction converted isomers under increasing concentrations denaturant. concentration guanidine thiocyanate, hydrochloride, urea required denature 50% was found be 0.7, 1.45,...
Bone mineral density (BMD) is a biomarker for cumulative exposure to multiple factors including estrogen, calcium, vitamin D and physical activity, which have all been independently associated with colorectal cancer. Furthermore, higher levels of BMD inversely cancer risk, particularly in postmenopausal women. However, no prior studies examined the potential association between adenomas, are precursor lesions most cancers. Therefore, we evaluated BMD, was measured using whole body,...
The secretory leukocyte protease inhibitor (SLPI) is a serine which plays important role in bacterial infection, inflammation, wound healing and epithelial proliferation. Dysregulation of SLPI has been reported variety human cancers including glioblastoma, lung, breast, ovarian colorectal carcinomas associated with tumor aggressiveness metastatic potential. However, the pathogenic cancer still unclear. Here we showed that mRNA level was significantly upregulated tissues compared to adjacent...