A5071610019- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Malaria Research and Control
- Lung Cancer Diagnosis and Treatment
- Receptor Mechanisms and Signaling
- HIV Research and Treatment
- Drug Transport and Resistance Mechanisms
- Plant Pathogens and Fungal Diseases
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Complement system in diseases
- Plant Pathogenic Bacteria Studies
- CAR-T cell therapy research
- Genomics and Phylogenetic Studies
- Cancer Genomics and Diagnostics
- Protein Kinase Regulation and GTPase Signaling
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Estrogen and related hormone effects
- Sphingolipid Metabolism and Signaling
- Pancreatic and Hepatic Oncology Research
- Mine drainage and remediation techniques
- Electrochemical sensors and biosensors
- Bacterial biofilms and quorum sensing
University of Wisconsin–Madison
2025
Peuplements végétaux et bioagresseurs en milieu tropical
2024
Bristol-Myers Squibb (United States)
2021-2024
Northeast Ohio Medical University
2024
Can Tho University of Medicine and Pharmacy
2023
Can Tho University
2023
Bristol-Myers Squibb (Sweden)
2021-2022
Deakin University
2022
Australian National University
2014-2021
University of California, Los Angeles
2020
IntroductionIn CheckMate 227, nivolumab plus ipilimumab prolonged overall survival (OS) versus chemotherapy in patients with tumor programmed death-ligand 1 (PD-L1) greater than or equal to 1% (primary end point) less (prespecified descriptive analysis). We report results minimum 4 years' follow-up.MethodsAdults previously untreated stage IV recurrent NSCLC were randomized (1:1:1) ipilimumab, nivolumab, (PD-L1 ≥1%); chemotherapy, <1%). Efficacy included OS and other measures. Safety timing...
To further characterize survival benefit with first-line nivolumab plus ipilimumab two cycles of chemotherapy versus alone, we report updated data from the phase III CheckMate 9LA trial a 2-year minimum follow-up.
LBA8010 Background: The phase 3 CheckMate 816 study established neoadjuvant NIVO + chemo as a standard of care for eligible pts with resectable NSCLC. Here, we report the 4-year survival update from this study, representing longest follow-up among all global studies evaluating or perioperative immunotherapy-based treatments. Methods: Adults stage IB (≥ 4 cm)–IIIA (per AJCC v7) NSCLC, ECOG PS ≤ 1, and no known EGFR/ ALK alterations were randomized 1:1 to receive 360 mg Q3W alone cycles,...
The development of differentiated sexual stages (gametocytes) within human red blood cells is essential for the propagation malaria parasite, since only mature gametocytes will survive in mosquito's midgut. Hence gametocytogenesis a pre-requisite transmission disease. Physiological changes involved differentiation are still enigmatic. In particular lipid metabolism—despite being central to cellular regulation and development—is not well explored. Here profiles infected with five different...
8521 Background: In CheckMate 816, neoadjuvant N + C demonstrated statistically significant and clinically meaningful improvements in event-free survival (EFS) pathologic complete response (pCR) vs pts with resectable NSCLC. Here, we report clinical outcomes or without definitive surgery following treatment (tx). Methods: Adults stage IB (tumors ≥ 4 cm) to IIIA (per AJCC 7th ed) NSCLC, ECOG PS ≤ 1, no known EGFR/ ALK mutations were randomized 1:1 3 cycles of 360 mg Q3W Q3W, followed by...
9016 Background: 1L NIVO + IPI was shown to provide durable long-term overall survival (OS) benefit vs chemo regardless of tumor programmed death ligand 1 (PD-L1) expression in patients (pts) with advanced NSCLC CheckMate 227 Part (NCT02477826); 3-year OS rates were 33% 22% pts PD-L1 ≥ 1% (HR, 0.79 [95% CI, 0.67–0.93]) and 34% 15% < 0.64 0.51–0.81]). Here we report updated results from the study 4 years’ minimum follow-up. Methods: Adults previously untreated stage IV / recurrent NSCLC,...
First-line nivolumab plus ipilimumab prolongs survival versus chemotherapy in advanced non-small-cell lung cancer (NSCLC). We further characterized clinical benefit with this regimen a large pooled patient population and assessed the effect of response on survival.
The genus Pseudomonas has one of the largest diversity species within Bacteria kingdom. To date, its taxonomy is still being revised and updated. Due to non-standardized procedure ambiguous thresholds at level, largely based on 16S rRNA gene or conventional biochemical assay, identification publicly available genomes remains questionable. In this study, we performed a large-scale analysis all with designation (excluding well-defined P. aeruginosa) re-evaluated their taxonomic assignment via...
Parastagonospora nodorum is an important pathogen of wheat. The contribution secondary metabolites to this pathosystem poorly understood. A biosynthetic gene cluster (SNOG_08608-08616) has been shown be upregulated during the late stage P. wheat leaf infection. shares several homologues with Cercospora nicotianae CTB encoding biosynthesis cercosporin. Activation by overexpression (OE) transcription factor (SNOG_08609) in resulted production elsinochrome C, a perelyenequinone phytotoxin...
LBA8511 Background: Several studies have shown an association of pathological response, a common efficacy endpoint in neoadjuvant therapy trials, with survival for chemo various cancers including resectable NSCLC. However, the between complete response (pCR) and as well degree regression that may be predictive EFS immunotherapy has not been rigorously studied. CheckMate 816 (NCT02998528), randomized phase 3 study NIVO + vs NSCLC, met both its primary endpoints statistically significant...
Chelation approaches that are compatible with a multitude of isotopes an important area development. Here, we introduce the design, synthesis, and evaluation 2,3-dihydroxyterephthalate/catechol chelator conjugates positron emission tomography (PET) 68Ga3+ 45Ti4+, targeting prostate-specific membrane antigen (PSMA). The made in multistep organic synthesis incorporating 2,3-dihydroxyterephthalate, linked to amino hexanoic acid-extended, urea-dipeptides EuE or KuE (substrates PSMA active site)....
Prodrug strategies are widely used to enhance the pharmacokinetics of organic, small molecule drugs. Herein, this approach rare earth coordination complexes is adopted with potential applications as diagnostic and therapeutic radiopharmaceuticals. Previously, chelator m ‐phospatcn (H 4 L2) identified suitable for radiolabeling 44 Sc 177 Lu at room temperature. However, functionalizing H L2 targeting vector conjugation destabilizes chelates, leading increased blood retention, liver...
9000 Background: In the randomized phase 3 CheckMate 9LA trial (NCT03215706), first-line NIVO + IPI combined with 2 cycles of chemo significantly improved overall survival (OS), progression-free (PFS), and objective response rate (ORR) vs alone (4 cycles). Clinical benefit was observed regardless programmed death ligand 1 (PD-L1) expression level histology. Here we report data years’ minimum follow-up from this study. Methods: Adult patients (pts) stage IV / recurrent NSCLC, ECOG performance...
Trials were conducted to identify new compounds that may be useful in the control of cereal aphids on wheat, Triticum aestivum (L.). Five plant proteinase inhibitors tested for their ability 3 species feeding trials. The against Russian wheat aphid, Diuraphis noxia (Mordvilko), green bug, Schizaphis graminum (Rondani), and bird cherry-oat Rhoalosiphum padi Two these compounds, potato I II, increased mortality among late instar reduced production nymphs Potato carboxypeptidase inhibitor...
The thyrotropin-releasing hormone (TRH) receptor undergoes rapid and extensive agonist-dependent phosphorylation attributable to G protein-coupled (GPCR) kinases (GRKs), particularly GRK2. Like many GPCRs, the TRH is predicted form an amphipathic helix, helix 8, between NPXXY motif at cytoplasmic end of seventh transmembrane domain palmitoylation sites Cys335 Cys337. Mutation all six lysine arginine residues residue 340 glutamine (6Q receptor) did not prevent from stimulating inositol...