A5102778365- Ferroptosis and cancer prognosis
- Thyroid Cancer Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Heart Rate Variability and Autonomic Control
- Microbial metabolism and enzyme function
- Cancer-related molecular mechanisms research
- Nutrition, Genetics, and Disease
- Peptidase Inhibition and Analysis
- Cancer, Lipids, and Metabolism
- Chromatin Remodeling and Cancer
- Radiomics and Machine Learning in Medical Imaging
- Science, Research, and Medicine
- Pancreatic and Hepatic Oncology Research
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Neuroscience of respiration and sleep
- Traumatic Brain Injury and Neurovascular Disturbances
- Acute Kidney Injury Research
- Viral-associated cancers and disorders
- Bone and Joint Diseases
- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Apelin-related biomedical research
- Chemotherapy-induced organ toxicity mitigation
Xiangya Hospital Central South University
2025
Central South University
2025
Peking University Cancer Hospital
2021-2024
Peking University International Hospital
2024
Peking University
2021-2024
James Cook University
2024
Guangxi Maternal and Child Health Hospital
2024
Gansu Provincial Hospital
2024
Jiangsu Province Hospital
2023
Nanjing Medical University
2023
Abstract Background Hepatocellular carcinoma (HCC) is among the most common forms of cancer and associated with poor patient outcomes. The emergence therapeutic resistance has hampered efficacy targeted treatments employed to treat HCC patients date. In this study, we conducted a series CRISPR/Cas9 screens identify genes synthetic lethality capable improving clinical responses. Methods CRISPR-based loss-of-function genetic were used target 18,053 protein-coding in cells chemotherapy-related...
ARID1A is among the most commonly mutated tumor suppressor genes in hepatocellular carcinoma (HCC). In this study, we conduct a CRISPR-Cas9 synthetic lethality screen using ARID1A-deficient HCC cells to identify approaches treat patients harboring deficiency. This strategy reveals that survival of these highly dependent on related tricarboxylic acid (TCA) cycle. Mechanistically, loss represses expression key glycolysis-related gene PKM, shifting cellular glucose metabolism from aerobic...
Clinical trials shows that remote ischemic preconditioning (IPC) can protect against contrast induced nephropathy (CIN) in risky patients, however, the exact mechanism is unclear. In this study, we explored whether renalase, an amine oxidase has been previously shown to mediate reno-protection by local IPC, would also same effect elicited IPC animal model. Limb was performed for 24h followed induction of CIN. Our results indicated limb prevented renal function decline, attenuated tubular...
Papillary thyroid cancer (PTC) is the most prevalent endocrine worldwide. Approximately 30 % of PTC patients will progress into advanced or metastatic stage and have a relatively poor prognosis. It well known that epithelial-mesenchymal transition (EMT) plays pivotal role in metastasis, resistance to therapy, recurrence. Clarifying molecular mechanisms EMT progression help develop targeted therapy PTC. The aberrant expression some transcription factors (TFs) participated many pathological...
Delayed heart rate recovery (HRR) after exercise, an indicator of cardiac autonomic nervous function (CANF), has been found to be associated with metabolic syndrome (MetS) in general populations. However, this relationship not extensively studied older adults. The present study aimed investigate the association between MetS and HRRs at 1, 2, 3 6 minutes exercise cardiorespiratory fitness (CRF) Chinese dwelling This retrospective, observational consecutively enrolled participants aged 60...
To study renalase's expression and distribution in renal tissues cells, renalase coded DNA vaccine was constructed, anti-renalase monoclonal antibodies were produced using immunization hybridoma technique, followed by further investigation with immunological testing western blotting to detect the of among tissue cells. Anti-renalase successfully prepared technique. Further studies antibody showed that expressed glomeruli, tubule, mesangial podocytes, tubule epithelial cells its supernatant....
Abstract Background Exploring predictive biomarkers and therapeutic strategies of ICBs has become an urgent need in clinical practice. Increasing evidence shown that ARID1A deficiency might play a critical role sculpting tumor environments various tumors be used as pan-cancer for immunotherapy outcomes. The current study aims to explored the immune-modulating Hepatitis B virus (HBV) related hepatocellular carcinoma (HBV-HCC) its potential immunotherapeutic implications. Methods In study, we...
Background . Magnolin is the major active ingredient of herb Magnolia fargesii which has anti-inflammatory and antioxidative effects. Oxidative stress apoptosis are involved in pathogenesis contrast-induced nephropathy (CIN). We hypothesize that could protect against CIN through antiapoptotic properties. Methods To test whether attenuate CIN, oxidative apoptosis, vivo vitro , we utilized a rat model ioversol-induced cell HK2 cells were treated with H 2 O Rats assigned to 4 groups (<mml:math...
Forkhead box protein subfamily P (FOXP) 1 has an important role in the control of gene transcription and is also reported to function as a tumor suppressor. The aim present study was explore regulatory mechanisms atherosclerosis by investigating microRNA‑206 (miR‑206) association between miR‑206 its potential target gene, FOXP1, vascular smooth muscle cells (VSMCs). Bioinformatics tools were utilized identify FOXP1 miR‑206. Luciferase reporter analysis used confirm this relationship binding...
Hypertonic NaCl infused into the carotid arteries increases mean arterial pressure (MAP) and changes sympathetic nerve activity (SNA) via cerebral mechanisms. We hypothesized that elevated sodium levels in blood supply to brain would induce differential responses renal cardiac SNA sensors located outside blood-brain barrier. To investigate this hypothesis, we measured simultaneously conscious sheep during intracarotid infusions of (1.2 M), sorbitol (2.4 or urea M) at 1 ml/min for 4 min each...
Abstract Interferon-gamma (IFN-γ) exerts anti-tumor effects by inducing ferroptosis. Based on CRISPR/Cas9 knockout screening targeting genome-wide protein encoding genes in HepG2 and SK-Hep-1 cell lines, we found that cAMP response element-binding (CREB) regulated transcription coactivator 3 (CRTC3) protects tumor cells from drug-induced ferroptosis significantly inhibits the efficacy of IFN-γ treatment hepatocellular carcinoma (HCC). Mechanistically, CRTC3 altered lipid patterns increased...
Fusion oncogenes are involved in the underlying pathology of advanced differentiated thyroid cancer (DTC), and even cause radioactive iodine (RAI)-refractoriness.
This study aimed to explore the causes, incidence, and risk factors of urinary tract infection patients in neurological intensive care unit (ICU). Patients (n = 916) admitted ICU from January 2005 December 2010 were retrospectively surveyed for infections. There 246 who diagnosed with hospital-acquired during that period time (26.9%). Forty-three cases upper infection, 203 lower infection. The top three strains Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae. Older age (UTI...
Background/Aims: Hypersensitive pain response is often observed in patients with Parkinson's disease (PD); however, the mechanisms responsible for hyperalgesia are not well understood. Chronic neuroinflammation one of hallmarks PD pathophysiology. Since midbrain periaqueductal gray (PAG) an important component descending inhibitory pathway controlling on central transmission, we examined role pro-inflammatory cytokines (PICs) system PAG regulating exaggerated evoked by PD. Methods: We used a...
Recurrence is the major death cause of differentiated thyroid carcinoma (DTC), and a better understanding recurrence risk at early stage may lead to make optimal medical decision improve patients’ prognosis. The 2015 American Thyroid Association (ATA) stratification system primary based on clinic-pathologic features most commonly used describe initial persistent/recurrent disease. Besides, multiple prognostics models multigenes expression profiles have been developed predict DTC patients....
This study aimed to explore the causes, incidence and outcome of renal insufficiency during pregnancy.All pregnant women admitted our hospital from September 2004 August 2007 were retrospectively screened for function. Patients divided into 3 groups according serum creatinine (Scr) level (mild insufficiency: Scr 70-123 μmol/l; moderate: 124-220 severe: >221 μmol/l).Seventy-five cases (2.51%) identified. Twenty-two (0.73%) had evidence chronic kidney disease before pregnancy. Compared...
Renalase is generated mainly by the kidneys, and renalase's expression in chronic kidney disease patients reduced due to renal dysfunction. In this study, human renalase recombinant protein with prokaryotic was used for immunization of male New Zealand rabbits, polyclonal antibodies against were obtained. To prepare verify antibody, as antigen rabbits immunized obtain anti-serum identification. On basis tubular epithelial cells tissue detected. Two anti-renalase constitutively expressed...